Adherence modeling study for Anti-retroviral Therapies (ART) for the treatment of HIV patients in Canada

Client: Parexel International

Project ID: P2018-065 / 2020 0970 211 000

Research Question/Objectives: Human Immunodeficiency Virus (HIV) patients’ adherence to antiretroviral therapy (ART) in Canada has been shown to be suboptimal for subsets of patients. Patient adherence is critical to ART effectiveness in both preventing progression to acquired immunodeficiency syndrome (AIDS) and in developing ART drug resistance. In recent years, a variety of highly-efficacious treatment regimens have been developed that have turned HIV infection into a chronic yet manageable condition. New and in-development therapies with simplified administration may further address the patient adherence gap, however there is a lack of granular evidence surrounding the current unmet need, and therefore how these treatments should fit in the care pathway.

Specifically, the research objectives of interest are:

• Describe the rates of adherence by treatment regime, treatment experience, age, and sex.
• Compare adherence of patients with different clinical characteristics, describe adherence rate change over time, understand co-morbid co-prescribed medication.

Results:

• June 2022