Pharmacoepidemiology and drug safety

Read our publications related to this topic.

Journal Articles

Journal Article

05/08/2026

Lithium toxicity from angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker co-prescription: a population-based cohort study

Ahmadi F, Muanda FT, McArthur E, Weir M, Garg AX. J Psychopharmacol. 2026; Aug 5 [Epub ahead of print].

Journal Article

04/08/2026

Examining the effect of newborn feeding method on postnatal length of stay and healthcare utilisation among Neonates With In-utero SSRI Exposure (NeoWISE): a retrospective cohort study

Cantin C, Li W, Snelgrove-Clarke E, Corsi D, Dennis CL, Ross-White A, Brogly S, Gaudet L. BMJ Paediatr Open. 2026; 10(1): e004689.

Journal Article

31/07/2026

Loneliness and initiation of potentially inappropriate pain and psychotropic medications: a retrospective cohort study

Savage RD, Bronskill SE, Gruneir A, Boblitz A, Guan J, Altaf A, Strauss R, Sanmartin C, Rosella LC, Stall NM, Chamberlain SA, McCarthy LM, Wang X, Yu C, Odugbemi T, Rochon PA. Drugs Aging. 2026; Jul 31 [Epub ahead of print].

Journal Article

29/06/2026

Association between sedative prescriptions after hospital discharge and falls and other adverse events in older adults: a population-based cohort study

Burry LD, Rose L, Pinto R, Williamson DR, Hill A, Scales DC, Bronskill S, Fowler R, Dolovich L, Fu L, Bell CM, Wunsch H. CMAJ. 2026; 198(25): E958-E968.

Journal Article

22/06/2026

Application of a novel Desirability of Outcome Ranking endpoint incorporating a Framework for Resistance Assessment and Microbiologic Evaluation in antibiotic trials: a proof-of-concept in a post hoc analysis of the BALANCE trial

Ong SWX, Patrikar A, Pinto R, Mahar RK, Rishu A, Davis JS, Fowler RA, Tong SYC, Daneman N. Open Forum Infect Dis. 2026; 13(6): ofag142.

Journal Article

18/06/2026

Safety of antibiotic audit and feedback: secondary analysis of a randomized controlled trial

Schwartz KL, Bai L, Brown KA, Tadrous M, Grimshaw JM, Witteman HO, Friedman L, Langford BJ, Leung V, Gomes T, Garber G, Taljaard M, Shuldiner J, Gushue S, Silverman M, Daneman N, Brehaut J, Presseau J, Leis JA, Lacroix M, Zwarenstein M, Masucci L, Thavorn K, Ivers N. J Antimicrob Chemother. 2026; 81(7): dkag216.

Journal Article

18/06/2026

Association between initial benzodiazepine prescribing patterns and time to benzodiazepine discontinuation: a population-based retrospective cohort study

Bozinoff N, Hauck TS, Kleinman RA, Sloan ME, Sproule BA, Vigod SN, Wyman J, Pequeno P, Gomes T. PLoS Med. 2026; 23(6): e1005126.

Journal Article

26/05/2026

Duration of systemic therapy in patients with metastatic EGFR-mutated non-small cell lung cancer and brain metastases

Yan M, Tjong M, Coburn N, Nguyen L, Sahgal A, Louie AV, Parmar A. Transl Lung Cancer Res. 2026; 15(5):120. Epub 2026 May 26.

Journal Article

12/05/2026

Risk of serious adverse events and death with low-dose methotrexate versus hydroxychloroquine in adults receiving dialysis

Muanda FT, Blake PG, Weir MA, Ahmadi F, Omrani MA, Abdullah SS, McArthur E, Sontrop JM, Urquhart BL, Garg AX. Semin Dial. 2026; May 12 [Epub ahead of print].

Journal Article

07/05/2026

Effectiveness and safety of SGLT2 inhibitor initiation in sacubitril-valsartan users with heart failure: a population-based cohort study

Wu CY, Shah BR, Ezekowitz JA, Sharma A, Wang T, Wu CF, Liu PP, Edwards JD, Swardfager W. Eur Heart J Cardiovasc Pharmacother. 2026; May 7 [Epub ahead of print].

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News Releases

News Release

11/12/2025

14/04/2025

Research Programs and appointed ICES Scientists

ICES scientists are appointed to the ICES Research Program which best fits their interests and, as such, become members of a network of health services researchers from across Ontario.

ICES Scientists Research Programs

Pharmacoepidemiology and drug safety

Journal Articles

Lithium toxicity from angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker co-prescription: a population-based cohort study

Examining the effect of newborn feeding method on postnatal length of stay and healthcare utilisation among Neonates With In-utero SSRI Exposure (NeoWISE): a retrospective cohort study

Loneliness and initiation of potentially inappropriate pain and psychotropic medications: a retrospective cohort study

Association between sedative prescriptions after hospital discharge and falls and other adverse events in older adults: a population-based cohort study

Application of a novel Desirability of Outcome Ranking endpoint incorporating a Framework for Resistance Assessment and Microbiologic Evaluation in antibiotic trials: a proof-of-concept in a post hoc analysis of the BALANCE trial

Safety of antibiotic audit and feedback: secondary analysis of a randomized controlled trial

Association between initial benzodiazepine prescribing patterns and time to benzodiazepine discontinuation: a population-based retrospective cohort study

Duration of systemic therapy in patients with metastatic EGFR-mutated non-small cell lung cancer and brain metastases

Risk of serious adverse events and death with low-dose methotrexate versus hydroxychloroquine in adults receiving dialysis

Effectiveness and safety of SGLT2 inhibitor initiation in sacubitril-valsartan users with heart failure: a population-based cohort study

News Releases

Study finds domperidone not associated with severe mental health outcomes in new mothers

ADHD prescriptions on the rise, study finds

Safer opioid supply improves health outcomes among people at high risk of overdose

Hospital visits for cannabis use linked to higher dementia risk, study finds

Contribution of cannabis use disorder to new cases of schizophrenia has almost tripled over the past 17 years

Psychedelic use linked to increased risk of schizophrenia, study finds

New surveillance tool will address perinatal opioid use and treatment

Common antibiotics carry small but serious risks of life-threatening drug reactions, but some are safer than others

Surge in fatal opioid overdoses in Ontario shelters, report finds

New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought

Research Programs and appointed ICES Scientists