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Trends in population attributable risk of Clostridioides difficile infection associated with common outpatient antibiotics in Ontario, Canada, 2017-2024

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We evaluated changes in population attributable risk of “4C” antibiotics for community-associated Clostridioides difficile infection in Ontario (2017–2024). Contributions from clindamycin, cephalosporins, and fluoroquinolones declined, whereas amoxicillin-clavulanate increased and became the leading contributor by 2022, highlighting a potential emerging target for outpatient antimicrobial stewardship.

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Wong MK, Daneman N, Langford BJ, Leung V, Schwartz KL, Brown KA. Infect Control Hosp Epidemiol. 2026; Oct 1 [Epub ahead of print].

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