Pharmacoepidemiology and drug safety

Read our publications related to this topic.

Journal Articles

01/10/2026

Intravenous thrombolysis for acute ischemic stroke across kidney function

Bota SE, Dixon S, Kapral MK, Hackam D, Sood MM, Sontrop JM, Garg AX. Nephrol Dial Transplant. 2026; Oct 1 [Epub ahead of print].

Journal Article

01/10/2026

Trends in population attributable risk of Clostridioides difficile infection associated with common outpatient antibiotics in Ontario, Canada, 2017-2024

Wong MK, Daneman N, Langford BJ, Leung V, Schwartz KL, Brown KA. Infect Control Hosp Epidemiol. 2026; Oct 1 [Epub ahead of print].

Journal Article

21/09/2026

Epilepsy after antipsychotic prescription in survivors of traumatic brain injury: a population-based cohort study

Ferraris A, Szmulewicz AG, Adhikari NKJ, Burry L, Hernández A, Wunsch H, Scales DC, Angriman F. Crit Care Med. 2026; Sep 21 [Epub ahead of print].

Journal Article

19/09/2026

Treatment outcomes after initiating buprenorphine/naloxone or methadone for opioid use disorder among First Nation Peoples in Ontario, Canada

Rebić N, Bragg S, McCormack D, Hamzat B, deGonzague B, Holton A, Mecredy G, Campbell T, Antoniou T, McGregor L, Bertram J, Pine K, Corbiere Y, Gomes T. Int J Drug Policy. 2026; 157(Pt A): 105513. Epub 2026 Sep 19.

Journal Article

15/09/2026

Characterizing trends and patterns in benzodiazepine-related toxicity deaths in Ontario: a descriptive cross-sectional study

Campbell T, Ledlie S, Leece P, Yang J, Hamzat B, Kolla G, Bozinoff N, Boyd R, Franklyn M, Smoke A, Shearer D, Gomes T. PLoS One. 2026; 21(9): e0355210.

Journal Article

10/09/2026

Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study

Rochon PA, Austin PC, Gurwitz JH, Wu W, Matai L, Zhang T, Li Z, Savage RD, Gruneir A, Li J, O’Mahony D, Petrovic M, Cherubini A, Onder G, Sternberg SA, McCarthy LM, Dalton K, Reppas-Rindlisbacher CE, Stall NM, Normand ST, Giannakeas V. BMJ. 2026; 394:e100499.

Journal Article

09/09/2026

Adherence to anticoagulants in people with stroke and atrial fibrillation: Implementation of standardised analytic methods in Australia and Canada

Dalli LL, Kilkenny MF, Chu A, Ilomaki J, Jackevicius C, Kapral MK, Vyas MV, Cadilhac D, Livori AC, Gall S, Yu AYX. Int J Stroke. 2026; Sep 9 [Epub ahead of print].

Journal Article

01/09/2026

Evaluating the incidence and predictors of chronic opioid use in early survivorship for patients with diffuse large B-cell lymphoma

Ravindran M, Peng J, Zipursky J, Luo J, Liu N, Chan KKW, Cheung MC, Mozessohn L. J Natl Cancer Inst. 2026; Sep 1 [Epub ahead of print].

Journal Article

25/08/2026

Methadone vs buprenorphine-naloxone in opioid overdose survivors

Kleinman RA, Larney S, Sule NO, Ma C, Hauck TS, Kurdyak P. JAMA Netw Open. 2026; 9(8): e2629313.

Journal Article

12/08/2026

Time trends in maternal attention-deficit/hyperactivity disorder and medication use in pregnancy

Egsgaard S, Brown HK, Zipursky J, Munk-Olsen T, Babujee A, Patrikar A, Lu M, Vigod SN. J Clin Psychiatry. 2026; 87(3): 26m16321.

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News Releases

News Release

11/12/2025

14/04/2025

Research Programs and appointed ICES Scientists

ICES scientists are appointed to the ICES Research Program which best fits their interests and, as such, become members of a network of health services researchers from across Ontario.

ICES Scientists Research Programs

Pharmacoepidemiology and drug safety

Journal Articles

Intravenous thrombolysis for acute ischemic stroke across kidney function

Trends in population attributable risk of Clostridioides difficile infection associated with common outpatient antibiotics in Ontario, Canada, 2017-2024

Epilepsy after antipsychotic prescription in survivors of traumatic brain injury: a population-based cohort study

Treatment outcomes after initiating buprenorphine/naloxone or methadone for opioid use disorder among First Nation Peoples in Ontario, Canada

Characterizing trends and patterns in benzodiazepine-related toxicity deaths in Ontario: a descriptive cross-sectional study

Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study

Adherence to anticoagulants in people with stroke and atrial fibrillation: Implementation of standardised analytic methods in Australia and Canada

Evaluating the incidence and predictors of chronic opioid use in early survivorship for patients with diffuse large B-cell lymphoma

Methadone vs buprenorphine-naloxone in opioid overdose survivors

Time trends in maternal attention-deficit/hyperactivity disorder and medication use in pregnancy

News Releases

Study finds domperidone not associated with severe mental health outcomes in new mothers

ADHD prescriptions on the rise, study finds

Safer opioid supply improves health outcomes among people at high risk of overdose

Hospital visits for cannabis use linked to higher dementia risk, study finds

Contribution of cannabis use disorder to new cases of schizophrenia has almost tripled over the past 17 years

Psychedelic use linked to increased risk of schizophrenia, study finds

New surveillance tool will address perinatal opioid use and treatment

Common antibiotics carry small but serious risks of life-threatening drug reactions, but some are safer than others

Surge in fatal opioid overdoses in Ontario shelters, report finds

New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought

Research Programs and appointed ICES Scientists