Pharmacoepidemiology and drug safety

Read our publications related to this topic.

Journal Articles

26/05/2026

Duration of systemic therapy in patients with metastatic EGFR-mutated non-small cell lung cancer and brain metastases

Yan M, Tjong M, Coburn N, Nguyen L, Sahgal A, Louie AV, Parmar A. Transl Lung Cancer Res. 2026; 15(5):120. Epub 2026 May 26.

Journal Article

12/05/2026

Risk of serious adverse events and death with low-dose methotrexate versus hydroxychloroquine in adults receiving dialysis

Muanda FT, Blake PG, Weir MA, Ahmadi F, Omrani MA, Abdullah SS, McArthur E, Sontrop JM, Urquhart BL, Garg AX. Semin Dial. 2026; May 12 [Epub ahead of print].

Journal Article

07/05/2026

Effectiveness and safety of SGLT2 inhibitor initiation in sacubitril-valsartan users with heart failure: a population-based cohort study

Wu CY, Shah BR, Ezekowitz JA, Sharma A, Wang T, Wu CF, Liu PP, Edwards JD, Swardfager W. Eur Heart J Cardiovasc Pharmacother. 2026; May 7 [Epub ahead of print].

Journal Article

06/05/2026

The association between cardiovascular medication use and survival in patients with advanced pancreatic adenocarcinoma

Mavros MN, Ladak F, Chan KKW, Nguyen L, Coburn NG, Raphael MJ. Ther Adv Med Oncol. 2026; 18:17588359261449094.

Journal Article

04/05/2026

Methadone is associated with superior long-term treatment retention compared with buprenorphine/naloxone in a large Canadian cohort

Morin KA, Tatangelo M, Acharya S, Labrosse D, Leary T, Thiyagaratnam D, Nosyk B, Marsh DC. J Stud Alcohol Drugs. 2026; May 4 [Epub ahead of print].

Journal Article

28/04/2026

Real-world trends in prenatal antirheumatic drug utilization in Ontario, Canada: a cross-sectional time-series analysis

Tharmarajah S, Hussain S, Guilcher SJT, McCarthy LM, Mahendira D, Berger H, Tadrous M. Arthritis Care Res (Hoboken). 2026; Apr 28 [Epub ahead of print].

Journal Article

23/04/2026

Effect of the COVID-19 pandemic on initiations of opioid agonist therapy in Ontario: a population-based interrupted time series analysis

Young S, Raboud J, Dodd Z, Barnett-Tapia C, Gomes T, Fairbairn N, Bayoumi AM. Int J Drug Policy. 2026; 153: 105275. Epub 2026 Apr 23.

Journal Article

22/04/2026

A population-based cross-sectional analysis of extended-release opioid dispensing incidence, prognostic factors, and variation after total joint arthroplasty

Malone JL, Tierney SL, McGinn RN, Talarico R, McIsaac DI. Anesthesiology. 2026; Apr 22 [Epub ahead of print].

Journal Article

20/04/2026

Cessation of amoxicillin-clavulanate selective reporting and association with antibiotic prescribing and C. difficile infection in Ontario, Canada, 2017-2024: an ecological study

Wong MK, Daneman N, Langford BJ, Leung V, Schwartz KL, Almohri H, Goneau LW, Brown KA. Clin Microbiol Infect. 2026; S1198-743X(26): 00199-0. Epub 2026 Apr 20.

Journal Article

09/04/2026

Association between early methadone dose titration and treatment discontinuation and opioid toxicity: a retrospective cohort study

Garg R, Luo J, Bozinoff N, Sproule B, Antoniou T, Wyman J, Leece P, Munro C, Besharh J, Gomes T. PLoS Med. 2026; 23(4): e1004748.

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News Releases

News Release

11/12/2025

14/04/2025

Research Programs and appointed ICES Scientists

ICES scientists are appointed to the ICES Research Program which best fits their interests and, as such, become members of a network of health services researchers from across Ontario.

ICES Scientists Research Programs

Pharmacoepidemiology and drug safety

Journal Articles

Duration of systemic therapy in patients with metastatic EGFR-mutated non-small cell lung cancer and brain metastases

Risk of serious adverse events and death with low-dose methotrexate versus hydroxychloroquine in adults receiving dialysis

Effectiveness and safety of SGLT2 inhibitor initiation in sacubitril-valsartan users with heart failure: a population-based cohort study

The association between cardiovascular medication use and survival in patients with advanced pancreatic adenocarcinoma

Methadone is associated with superior long-term treatment retention compared with buprenorphine/naloxone in a large Canadian cohort

Real-world trends in prenatal antirheumatic drug utilization in Ontario, Canada: a cross-sectional time-series analysis

Effect of the COVID-19 pandemic on initiations of opioid agonist therapy in Ontario: a population-based interrupted time series analysis

A population-based cross-sectional analysis of extended-release opioid dispensing incidence, prognostic factors, and variation after total joint arthroplasty

Cessation of amoxicillin-clavulanate selective reporting and association with antibiotic prescribing and C. difficile infection in Ontario, Canada, 2017-2024: an ecological study

Association between early methadone dose titration and treatment discontinuation and opioid toxicity: a retrospective cohort study

News Releases

Study finds domperidone not associated with severe mental health outcomes in new mothers

ADHD prescriptions on the rise, study finds

Safer opioid supply improves health outcomes among people at high risk of overdose

Hospital visits for cannabis use linked to higher dementia risk, study finds

Contribution of cannabis use disorder to new cases of schizophrenia has almost tripled over the past 17 years

Psychedelic use linked to increased risk of schizophrenia, study finds

New surveillance tool will address perinatal opioid use and treatment

Common antibiotics carry small but serious risks of life-threatening drug reactions, but some are safer than others

Surge in fatal opioid overdoses in Ontario shelters, report finds

New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought

Research Programs and appointed ICES Scientists