Patient Journey & Burden of Illness of Individuals with Aortic Stenosis in Ontario, Canada: An observational, retrospective administrative data study

Summary

Client: IQVIA Solutions Canada Inc.

Project ID: P2024-228/ 2026 0980 012 000

Research Question/Objectives: Aortic stenosis (AS) is a type of valvular heart disease where the aortic valve narrows, restricting blood flow from the heart. Treatment options include surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). Despite the increasing prevalence of AS and the risks it poses, only 3% of Canadians are aware of the disease and its potential complications. Evidence on the AS patient journey is urgently needed in Canada, particularly around delays in diagnosis and treatment, and the potential impact on patient outcomes from AS. Increased public awareness, early detection, and treatment of AS may help improve the burden of illness and mitigate complications, such as heart failure and stroke, and reduce mortality. For the purposes of this study, the treated AS population refers to anyone that received SAVR/TAVR.

Objectives:

The primary objectives of this study are to:

1. Describe the time between key milestones in the pathway to SAVR/TAVR for the treated AS population in Ontario, Canada
2. Characterize the average patient journey for the treated AS population in Ontario, Canada

The secondary objectives of this study are to:

1. Describe the demographic and clinical characteristics of the treated AS population in Ontario, Canada
2. Describe the prevalence and incidence of SAS in Ontario, Canada
3. Describe the HCRU and direct healthcare costs of the treated AS population in Ontario, Canada
4. Describe the HCRU and direct healthcare costs of the treated AS population based on the duration of the patient journey
5. Describe the post-procedure complications and rehospitalizations of the treated AS population

Status: In progress