Burden of illness of transfusion-dependent beta thalassemia disease in Canada

Summary

Client: IQVIA Solutions Canada Inc.

Project ID: P2022-122B / 2024 0970 328 001

Research Question/Objectives: Hemoglobinopathies represent a group of lifelong, autosomal recessive genetic disorders that affect the structure or production of hemoglobin (Hb) molecule. β-thalassemia is caused by a mutation that impacts β-globulin chains. Patients with β-thalassemia do not produce hemoglobin endogenously and therefore must receive red blood cell transfusions. Severe forms of thalassemia that require regular blood transfusions are known as transfusion-dependent thalassemia (TDT).

Objectives:

1. Describe baseline characteristics of cohorts
2. Describe acute and chronic complications of cohorts
3. Describe treatment patterns of cohorts
4. Describe the all-cause healthcare resource utilization (HCRU).

Status: In progress