Rhabdomyolysis and sodium-glucose-linked transport inhibitors in patients taking statins
Harel Z, Jeyakumar N, Smith G, Ray JG, Clemens KK, Juurlink DN. JAMA Netw Open. 2024; 7(11):e2446641.
Aim — To test whether an audit and feedback-based intervention improved HbA1c 12 months after transfer to type 1 diabetes adult care.
Methods — Multi-centre, quasi-experimental pre-post study of an AF-based intervention targeting paediatric diabetes teams, which encouraged the implementation of an evidence-informed structured transition process at five paediatric diabetes centres in Ontario, Canada. Participants entered the study at their final paediatric visit. A parallel control cohort was ascertained using population-based administrative datasets. The primary outcome was HbA1c 12 months after transfer. The main exposure was the study period: pre-implementation (June 2018–May 2019); early-implementation (June 2019–September 2020); and late-implementation (October 2020–September 2021). Multivariable linear regression models were fit separately in each cohort.
Results — There were 449 and 2844 individuals in the intervention and control cohorts, respectively. Twelve months after transfer, participants in the late-implementation intervention cohort had an HbA1c that was, on average, 0.41% lower than participants in the pre-implementation period (p = 0.016). Among the control cohort, there was no significant difference in the HbA1c 12 months after transfer between study periods.
Conclusions — We found an effect of the intervention on glycaemic management one year following transfer to adult care. Future work will focus on refining and testing the effectiveness of the intervention in an expanded number of study sites and in collaboration with adult diabetes care providers.
Shulman R, Zenlea I, Ivers N, Austin PC, Li P, Clarson C, Landry A, Harrington J, Mukerji G, Palmert MR, Parsons J, Punthakee Z, Shah BR. Diabet Med. 2024; Oct 29 [Epub ahead of print]
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