Pharmacoepidemiology and drug safety

Read our publications related to this topic.

Journal Articles

02/12/2025

Hospital-based care for hallucinogens and risk of mania and bipolar disorder: a population-based cohort study

Myran DT, MacDonald-Spracklin R, Pugliese M, Gibb M, Fiedorowicz JG, Kaster TS, Solmi M. PLoS Med. 2025; 22(12): e1004805.

Journal Article

25/11/2025

Effect of nonmedical cannabis legalization and exposure to retail stores on cannabis harms: a quasi-experimental study

Friesen EL, Pugliese M, MacDonald-Spracklin R, Manuel D, Wilson K, Hobin E, Pinto AD, Myran DT. Ann Intern Med. 2025; Nov 25 [Epub ahead of print].

Journal Article

24/11/2025

Trimethoprim-sulfamethoxazole and acute respiratory failure in adolescents and young adults

Ahmadi F, McArthur E, Garcia-Bournissen F, Rieder MJ, Muanda FT. JAMA Netw Open. 2025; 8(11): e2545251.

Journal Article

17/11/2025

Initiation of opioid agonist treatment following hospital-treated opioid toxicities and the risk of repeat events in Ontario, Canada: a cohort study using inverse probability of treatment weights

Ledlie S, Tadrous M, Bayoumi AM, McCormack D, Kent JT, Besharah J, Munro C, Gomes T. BMJ Public Health. 2025; 3(2): e002779.

Journal Article

15/11/2025

Prevalence of prescribed opioid claims among persons with non-traumatic spinal cord dysfunction in Ontario, Canada: a population-based retrospective cohort study

Guan Q, Hogan ME, Calzavara A, McCormack D, Lofters AK, Patel T, Hitzig SL, Packer T, Guilcher SJT. Spinal Cord. 2025; Nov 15 [Epub ahead of print]. 41241697.

Journal Article

15/11/2025

Systemic therapies for psoriatic disease and serious adverse events in older adults: a population-based cohort study

Drucker AM, Sutradhar R, Ling V, Eder L, Gomes T, Fralick M, Iskandar RJ, Li P, MacDougall S, Manolson M, Rochon PA, Tadrous M. J Invest Dermatol. 2025; S0022-202X(25)03528-6. Epub 2025 Nov 15.

Journal Article

08/11/2025

Cardiovascular effectiveness and safety of SGLT2 inhibitors vs DPP4 inhibitors by dementia status: a cohort study of older adults with diabetes

Wu CY, Sharma A, Edwards JD, Liu PP, Kapral MK, Herrmann N, Wu CF, Podolsky S, Swardfager W, Shah BR. Diabetologia. 2025; Nov 8 [Epub ahead of print].

Journal Article

07/11/2025

Association of direct oral anticoagulant-anticonvulsant co-prescription with clinical outcomes in older adults: a population-based cohort study

Carlin S, Holbrook AM, Candeloro M, Nguyen F, Paterson JM, Douketis J. J Thromb Haemost. 2025; S1538-7836(25)00727-5. Epub 2025 Nov 7.

Journal Article

04/11/2025

Validity of the International Classification of Diseases, 10th Revision codes for lithium toxicity in adult patients at hospital admission: a cohort study in Canada

Ahmadi F, Muanda FT, Ehiwario J, McArthur E, Jandoc R, Slater J, Vasudev A, Weir MA, Clark EG, Rej S, Herrmann N, Garg AX. BMJ Open. 2025; 15(11):e097196.

Journal Article

27/10/2025

Trends in prescription opioid use for pain in Canada: a population-based repeated cross-sectional study of 6 provinces

Rebic N, Hamzat B, Cheung G, Eurich D, Kabore J-L, de Leseleuc L, Liu Z, Missaoui H, Randall J, Shearer D, Stocke D, Yang J, Gomes T. CMAJ. 197(36):E1175-E1183.

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News Releases

News Release

22/04/2025

Safer opioid supply improves health outcomes among people at high risk of overdose

A new study in The Lancet Public Health finds that safer supply programs complement existing treatment options.

News Release

14/04/2025

Research Programs and appointed ICES Scientists

ICES scientists are appointed to the ICES Research Program which best fits their interests and, as such, become members of a network of health services researchers from across Ontario.

ICES Scientists Research Programs

Pharmacoepidemiology and drug safety

Journal Articles

Hospital-based care for hallucinogens and risk of mania and bipolar disorder: a population-based cohort study

Effect of nonmedical cannabis legalization and exposure to retail stores on cannabis harms: a quasi-experimental study

Trimethoprim-sulfamethoxazole and acute respiratory failure in adolescents and young adults

Initiation of opioid agonist treatment following hospital-treated opioid toxicities and the risk of repeat events in Ontario, Canada: a cohort study using inverse probability of treatment weights

Prevalence of prescribed opioid claims among persons with non-traumatic spinal cord dysfunction in Ontario, Canada: a population-based retrospective cohort study

Systemic therapies for psoriatic disease and serious adverse events in older adults: a population-based cohort study

Cardiovascular effectiveness and safety of SGLT2 inhibitors vs DPP4 inhibitors by dementia status: a cohort study of older adults with diabetes

Association of direct oral anticoagulant-anticonvulsant co-prescription with clinical outcomes in older adults: a population-based cohort study

Validity of the International Classification of Diseases, 10th Revision codes for lithium toxicity in adult patients at hospital admission: a cohort study in Canada

Trends in prescription opioid use for pain in Canada: a population-based repeated cross-sectional study of 6 provinces

News Releases

Safer opioid supply improves health outcomes among people at high risk of overdose

Hospital visits for cannabis use linked to higher dementia risk, study finds

Contribution of cannabis use disorder to new cases of schizophrenia has almost tripled over the past 17 years

Psychedelic use linked to increased risk of schizophrenia, study finds

New surveillance tool will address perinatal opioid use and treatment

Common antibiotics carry small but serious risks of life-threatening drug reactions, but some are safer than others

Surge in fatal opioid overdoses in Ontario shelters, report finds

New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought

People who died from a substance-related overdose faced significant gaps in treatment, report finds

Heavy cannabis use increases risk of developing an anxiety disorder, study suggests

Research Programs and appointed ICES Scientists