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Uptake and Outcomes Associated with Cyclooxgenase (COX-2) Inhibitors in Ontario’s Elderly


Many clinical and policy questions related to outcomes and costs have arisen following the recent introduction of a group of nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase (COX-2) inhibitors, to drug formularies.

The purpose of this report is to:

  • Examine clinically relevant outcomes associated with COX-2 inhibitors relative to nonselective NSAIDS among an elderly population;
  • Examine changes in population costs to the healthcare system and clinical outcome rates following the introduction of COX-2 inhibitors to the Ontario Drug Benefit formulary; and
  • Examine basic adherence rates associated with COX-2 inhibitors and nonselective NSAIDS among an elderly population.



Mamdani M, Kopp A, Laupacis A, Rochon PA, Juurlink DN, Anderson GM, Naglie G, Austin PC, Lee DS, Stukel T . July 2005

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