The rise and fall of raloxifene use for osteoporosis, 1999-2022
Shogry FF, Hayes KN, Kim S, Burden AM, Tadrous M, Aggarwal S, Cadarette SM. Osteoporos Int. 2025 Jun 11 [Epub ahead of prin]t.
Quantification of the risk of corticosteroid-induced diabetes mellitus among the elderly
We conducted a population-based cohort study using administrative databases to quantify the association between oral and inhaled corticosteroid use and onset of diabetes mellitus in the elderly. Proton pump inhibitor (PPI) users were used as a control group. Relative to PPI users (N = 53,845), oral corticosteroid users (N = 31,864) were more likely to develop diabetes (adjusted rate ratio [aRR], 2.31; 95% confidence interval [95% CI], 2.11 to 2.54); however, inhaled corticosteroid users (N = 38,441) were not (aRR, 1.03; 95% CI, 0.93 to 1.14). The estimated number needed to harm for continuous use of oral corticosteroids relative to PPIs over 1, 2, and 3 years of use were 41, 23, and 16, respectively.