Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
Lau J, Scott MM, Everett K, Gomes T, Tanuseputro P, Jennings S, Bagnarol R, Zimmermann C, Isenberg SR. CMAJ. 2024;
Although there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.
Mamdani M, Ching A, Golden B, Melo M, Menzefricke U. Ann Pharmacother. 2008; 42(5):704-7.
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