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Challenges to evidence-based prescribing in clinical practice


Although there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.



Mamdani M, Ching A, Golden B, Melo M, Menzefricke U. Ann Pharmacother. 2008; 42(5):704-7.

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