Validation of international algorithms to identify adults with inflammatory bowel disease in health administrative data from Ontario, Canada
Benchimol EI, Guttmann A, Mack DR, Nguyen GC, Marshall JK, Gregor JC, Wong J, Forster AJ, Manuel DG. J Clin Epidemiol. 2014; 67(8):887-96. Epub 2014 Apr 26.
Objective — Health administrative databases can be used to track disease incidence, outcomes, and care quality. Case validation is necessary to ensure accurate disease ascertainment using these databases. In this study, the authors aimed to validate adult-onset inflammatory bowel disease (IBD) identification algorithms.
Study Design and Setting — The authors used two large cohorts of incident patients from Ontario, Canada to validate algorithms. The authors linked information extracted from charts to health administrative data and compared the accuracy of various algorithms. In addition, they validated an algorithm to distinguish patients with Crohn's from those with ulcerative colitis and assessed the adequate look-back period to distinguish incident from prevalent cases.
Results — Over 5,000 algorithms were tested. The most accurate algorithm to identify patients 18 to 64 years at diagnosis was five physician contacts or hospitalizations within 4 years (sensitivity, 76.8%; specificity, 96.2%; positive predictive value (PPV), 81.4%; negative predictive value (NPV), 95.0%). In patients ≥65 years at diagnosis, adding a pharmacy claim for an IBD-related medication improved accuracy.
Conclusion — Patients with adult-onset incident IBD can be accurately identified from within health administrative data. The validated algorithms will be applied to administrative data to expand the Ontario Crohn's and Colitis Cohort to all patients with IBD in the province of Ontario.