The performance of marginal structural models for estimating risk differences and relative risks using weighted univariate generalized linear models
Austin PC. Stat Methods Med Res. 2024; Apr 24 [Epub ahead of print].
Objective — To determine whether neighbours who share the same family physicians have better cardiovascular and healthcare outcomes.
Design — Retrospective cohort study using administrative health databases.
Setting — Ontario.
Participants — The study population included 2,690,482 adult patients cared for by 1710 family physicians.
Interventions — Adult residents of Ontario were linked to their family physicians and the geographic distance between patients in the same panel or list was calculated. Using distance between patients within a panel to stratify physicians into quintiles of panel proximity, physicians and patients from close-proximity practices were compared with those from more-distant-proximity practices. Age- and sex-standardized incidence rates and hazard ratios from cause-specific hazards regression models were determined.
Main Outcome Measures — The occurrence of a major cardiovascular event during a 5-year follow-up period (2008 to 2012).
Results — Patients of panels in the closest-proximity quintile lived an average of 3.9 km from the 10 closest patients in their panel compared with 12.4 km for the 10 closest patients of panels in the distant-proximity quintile. After adjusting for various patient and physician characteristics, patients in the most-distant-proximity practices had a 24% higher rate of cardiovascular events (adjusted hazard ratio=1.24 [95% CI 1.20 to 1.28], P<.001) than patients in the closest-proximity practices. Age- and sex-standardized all-cause mortality and total per patient healthcare costs were also lowest in the closest-proximity quintile. In sensitivity analyses restricted to large urban communities and to White long-term residents, results were similar.
Conclusion — The better cardiovascular outcomes observed in close-proximity panels may be related to a previously unrecognized mechanism of social connectedness that extends the effectiveness of primary care practitioners.
Hogg W, Kotb A, Chu A, Gozdyra P, Sivaswamy A, Fang J, Kendall CE, Tu J. Can Fam Physician. 2022; 68(9):671-80. Epub 2022 Sep 13.
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