The performance of marginal structural models for estimating risk differences and relative risks using weighted univariate generalized linear models
Austin PC. Stat Methods Med Res. 2024; Apr 24 [Epub ahead of print].
The role of sex in the outcomes of patients with biliary tract cancers remains unclear: a population-based study
Background — Differences in outcomes between males and females with biliary tract cancer (BTC) has been previously reported but not studied.
Methods — This was a population-based retrospective cohort study of patients undergoing BTC resection in Ontario between 2002 and 2012. Descriptive statistics on patient, disease, and treatment-related factors in each BTC subtype were reported. Kaplan Meier Curves and Cox Proportional Hazards analysis were used to examine the univariate relationship between sex and overall survival.
Results — 714 patients underwent resection of a BTC. Kaplan Meier Curves shows trends towards different survival for males and females in different BTC subtypes: improved for females with intrahepatic and ampullary cancers and poorer survival for females with perhilar and distal cholangiocarcinomas. These trends were not statistically significant.
Conclusions — Sex may be an important factor in overall survival following resection of BTC. Further work is needed to better characterize the relationship between sex and outcomes of BTC.
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Citation
Lemke M, DeWit Y, Nanji S, Booth CM, Flemming JA. Am J Surg. 2018; 216(6):1118-21. Epub 2018 Jun 19.