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The Incidence and Burden of Clostridium Difficile in Ontario

Client: Sanofi Pasteur

Project ID: P2016-002 / 2017 0970 071 000

Research Question/Objectives: The objective of this research is to utilize linked health administrative databases in Ontario to establish the burden of Clostridium difficile (CDI) in Canada’s most populous province. Through the use of descriptive statistics, regression modeling and matched case-control analysis, this study will answer important questions about CDI which are necessary for optimal decision-making regarding prevention and treatment planning. Specifically , the research questions of interest are:

  • To measure the annual incidence of CDI in Ontario, both overall and in acute care hospitals, long-term care facilities, and community-dwelling populations
  • To determine the complication rates associated with CDI in these populations, compared to control groups with similar demographics and medical history
  • To estimate the cost of healthcare utilization associated with CDI in Ontario.