Low-dose methotrexate and serious adverse events among older adults with chronic kidney disease
Muanda FT, Blake PG, Weir MA, Ahmadi F, McArthur E, Sontrop JM, Urquhart BL, Kim RB, Garg AX. JAMA Netw Open. 2023; 6(11):e2345132. Epub 2023 Nov 27.
While medications are the foundation of therapy for many illnesses, they can occasionally cause unintended injury. Adverse drug events (or ADEs) vary in predictability and severity, and though some are simply unavoidable, interactions between drugs are among the most preventable. A recent study conducted in Ontario found that avoidable drug interactions increased the risk for hospital admission for drug toxicity up to twenty fold.
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