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The safety of levofloxacin in elderly patients on warfarin

Stroud LF, Mamdani MM, Kopp A, Bell CM. Am J Med. 2005; 118(12):1417.

Warfarin is commonly prescribed to treat and prevent thrombosis in individuals with atrial fibrillation, central venous catheters, mechanical heart valves, deep vein thrombosis, and pulmonary embolism.1-8 Despite its widespread use, warfarin has a narrow therapeutic index. Many variables may influence its action and increase the risk of hemorrhagic complications, even with stable dosing. Concomitant use of medications, particularly short-term antibiotics,
may be an important source of such an interaction.

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Keywords: Geriatrics and aging Drugs (cardiovascular) Drug interactions