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The safety of levofloxacin in elderly patients on warfarin


Warfarin is commonly prescribed to treat and prevent thrombosis in individuals with atrial fibrillation, central venous catheters, mechanical heart valves, deep vein thrombosis, and pulmonary embolism.1-8 Despite its widespread use, warfarin has a narrow therapeutic index. Many variables may influence its action and increase the risk of hemorrhagic complications, even with stable dosing. Concomitant use of medications, particularly short-term antibiotics,
may be an important source of such an interaction.



Stroud LF, Mamdani MM, Kopp A, Bell CM. Am J Med. 2005; 118(12):1417.

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