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Risk of invasive cervical cancer among immigrants in Ontario, Canada


Background — The risk of invasive cervical cancer (ICC) varies throughout the world. We aimed to compare the risk of this invasive disease among immigrants arriving in Ontario with that of the general female population of Ontario.

Methods — We used an exposure-control matched design. We identified females from the Immigration, Refugees, and Citizenship Canada (IRCC) database with arrival in Ontario, and whose first eligibility for the Ontario Health Insurance Plan according to its Registered Persons Database fell between July 1, 1991, and June 30, 2008, at age 20 years or older, and matched two female controls on year of birth. We identified cases of ICC between the index date and December 31, 2014. Crude rates and relative rates of ICC were calculated. Multivariable extended Cox regression models were then implemented.

Results — The crude rate of ICC was 0.032 per 100 000 person-years for immigrants and 0.037 for controls. Immigrants who were born in certain countries showed a higher risk of ICC; Russia had a relative rate of 1.736 compared with a relative rate of 0.221 among those born in Iran. Among immigrants, the age-adjusted HR was 0.76 (95% CI 0.63–0.92) after 10 years of residency when compared with controls. Immigrants aged 20 to 39 years had a lower risk of ICC compared with controls of equivalent age, and immigrants aged ≥40 years had a higher risk of ICC.

Conclusion — The risk of ICC among immigrants in Ontario varies by age, country of birth, and time since immigration.



Aston O, Sutradhar R, Rabeneck L, Paszat L. J Obstet Gynaecol Can. 2019; 41(1):21-8. Epub 2018 Oct 10.

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