Low-dose methotrexate and serious adverse events among older adults with chronic kidney disease
Muanda FT, Blake PG, Weir MA, Ahmadi F, McArthur E, Sontrop JM, Urquhart BL, Kim RB, Garg AX. JAMA Netw Open. 2023; 6(11):e2345132. Epub 2023 Nov 27.
Landmark clinical trials can influence prescribing behavior. We examined patterns of prescriptions for estrogen replacement therapy (ERT) before and after publication of the Women's Health Initiative (WHI) study on July 17, 2002. We also examined trends around the publication of the Heart and Estrogen/progestin Replacement Study (HERS) in 1998.
Austin PC, Mamdani MM, Tu K, Jaakkimainen L. JAMA. 2003; 289(24):3241-2.
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