Methadone vs buprenorphine-naloxone in opioid overdose survivors
Kleinman RA, Larney S, Sule NO, Ma C, Hauck TS, Kurdyak P. JAMA Netw Open. 2026; 9(8): e2629313.
Clinical researchers frequently assess the statistical significance of the difference between two means by examining whether the two 95% confidence intervals overlap. The purpose of this brief communication is to illustrate that the 95% confidence intervals for two means can overlap and yet the two means can be statistically significantly different from one another at the alpha = 0.05 level.