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High opioid use in older people living with chronic obstructive pulmonary disease raises safety concerns


Researchers are raising safety concerns about high rates of new opioid use among older adults with chronic obstructive pulmonary disease, according to a new study published today in the British Journal of Clinical Pharmacology.

“The new use of opioids was remarkably high among adults with COPD living in the community,” said Dr. Nicholas Vozoris, a respirologist at St. Michael’s Hospital. “The amount of opioid use is concerning given this is an older population, and older adults are more sensitive to narcotic side effects.”

The study is based on records for more than 120,000 adults in Ontario age 66 and older with COPD, a progressive lung disease that makes it difficult to breathe. Multiple provincial healthcare administrative databases were analyzed at the Institute for Clinical Evaluative Sciences (ICES).

Between 2003 and 2012, 70 per cent of those who were living in their own home were given a new opioid prescription, while about 55 per cent of those living in long-term care homes received a new opioid prescription. The study also found that older adults with COPD, especially those living in long-term care homes, were potentially using opioids excessively – meaning they were given multiple opioid prescriptions, early refills, and prescriptions that lasted more than 30 days.

Opioids, such as codeine, oxycodone and morphine might be prescribed more frequently among older adults with COPD to treat chronic muscle pain, breathlessness and insomnia, said Dr. Vozoris. Common side effects of opioids include falls and fractures, confusion, memory impairment, fatigue, constipation, nausea, vomiting and abdominal pain.

“Sometimes patients are looking for what they think are quick fixes to chronic pain and chronic breathing problems,” said Dr. Vozoris. “And physicians sometimes believe that narcotics may be a quick fix to COPD symptoms.”

Dr. Vozoris said there was some evidence to suggest that opioids may negatively affect lung health by reducing breathing rates and volume, which can result in decreased blood oxygen levels and higher carbon dioxide levels.
“This is a population that has chronic lung disease, and this drug class may also adversely affect breathing and lung health in people who already have chronically compromised lungs,” said Dr. Vozoris.

The authors looked at records of about 110,000 adults living in the community and about 16,000 adults living in long-term care homes in Ontario.

The majority of opioid prescriptions came from family physicians, with about 88 per cent of new prescriptions being a mixture of opioids and non-opioids, such as Percocet, Endocet and Lenoltec.

“Patients and prescribers should reflect on the way narcotics are being used in this older and respiratory-vulnerable population,” said Dr. Vozoris. “They should be more careful about when narcotics are used and how they’re being used.”

This research was funded by a grant from the Lung Association-Canadian Thoracic Society National Grant Review/Grant-in-Aid.

Author block: Nicholas T Vozoris, Xuesong Wang, Hadas D Fischer, Andrea S Gershon, Chaim M Bell, Sudeep S Gill, Denis E O'Donnell, Peter C Austin, Anne L Stephenson, Paula A Rochon.

St. Michael’s Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future healthcare professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the hospital’s recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael’s Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

ICES is an independent, non-profit organization that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. For the latest ICES news, follow us on Twitter: @ICESOntario

For more information, please contact:

  • Corinne Ton That
  • Communications and Public Affairs
  • St. Michael's Hospital
  • 416-864-6060 ext.7178
  • [email protected]

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