An observational study of Osteogenesis Imperfecta in Ontario, Canada: burden of illness and healthcare resource utilization

Client: IQVIA Solutions Canada Inc.

Project ID: P2022-140/2024 0970 337 000

Research Question/Objectives: Osteogenesis Imperfecta (OI) represents a group of genetic disorders with high fracture incidence due to increased bone brittleness and decreased bone mass. Fractures begin in early childhood but rates decline gradually during adolescence and further upon cessation of growth.

Primary objectives:
1. To estimate the incidence and prevalence of OI in Ontario, Canada
2. To describe the demographics of OI patients diagnosed in Ontario, and their comorbidities

Secondary objectives:
3. To describe the therapies received by OI patients in Ontario
4. To characterize the burden of illness (BOI) [i.e., the direct healthcare costs and healthcare resource utilization (HCRU)], including clinical outcomes and fracture rate, among OI patients diagnosed in Ontario
5. If feasible, describe BOI and treatment patterns by fracture history

Exploratory objective:
6. If feasible, describe fracture rate by age cohorts

Results: In progress