{"id":21735,"date":"2024-12-01T13:00:17","date_gmt":"2024-12-01T18:00:17","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=public_project&#038;p=21735"},"modified":"2026-03-11T13:48:08","modified_gmt":"2026-03-11T17:48:08","slug":"outcomes-after-esophageal-discontinuity-a-population-based-analysis-of-reversal-rates-and-outcomes","status":"publish","type":"public_project","link":"https:\/\/www.ices.on.ca\/fr\/services-for-researchers\/all-projects\/public-sector-projects\/outcomes-after-esophageal-discontinuity-a-population-based-analysis-of-reversal-rates-and-outcomes\/","title":{"rendered":"Outcomes after esophageal discontinuity: a population-based analysis of reversal rates and outcomes"},"content":{"rendered":"<p><strong>Project ID:<\/strong> 2022-1028\/ TRIM 2025 0970 402 000<\/p>\n<p><strong>Project title:<\/strong> Outcomes after esophageal discontinuity: a population-based analysis of reversal rates and outcomes<\/p>\n<p><strong>Principal Investigator:<\/strong> Elliot Wakeam<\/p>\n<p><strong>Description:<\/strong> The need to establish esophageal discontinuity usually arises out of complications of esophageal resection and reconstruction in course of the treatment of cancers of the esophagus and stomach, repair of hiatal hernias, or esophageal perforations. Regardless of etiology, it is usually a \u2018damage control\u2019 approach to severe mediastinitis and sepsis that results from the initial perforation or dehiscence. It can also be part of an approach to the remedy of certain congenital malformations as well. In any case, the outcomes for this group of patients, whether they undergo the procedure as damage control or as a planned operation, are as unknown, as is the prevalence. The reversal rates, and long-term survival outcomes, for cancer-related and non-cancer related indications is likewise unknown. Hence the goal of the study is to characterize the prevalence of these patients in the population and to characterize their outcomes in terms of survival, quality of life, and healthcare utilization. Importantly, the project team seeks out to characterize reversal rates and additional subsequent procedures performed using an Ontario wide population-based data set. The goal of this long term work, is to inform the potential recipient population for the development of esophageal transplantation as a treatment for \u201cforegut failure\u201d.<\/p>\n<p><strong>PIA approved:<\/strong> September 24, 2024<\/p>\n<p><strong>Project status:<\/strong> In progress<\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project ID: 2022-1028\/ TRIM 2025 0970 402 000 Project title: Outcomes after esophageal discontinuity: a population-based analysis of reversal rates and outcomes Principal Investigator: Elliot Wakeam Description: The need to establish esophageal discontinuity usually arises out of complications of esophageal resection and reconstruction in course of the treatment of cancers of the esophagus and stomach, [&hellip;]<\/p>\n","protected":false},"template":"","organization_type":[],"project_status":[104],"response_type":[],"class_list":["post-21735","public_project","type-public_project","status-publish","hentry","project_status-in-progress"],"acf":{"project_id":"2022-1028\/ TRIM 2025 0970 402 000","project_id_year":2026,"ices_scientist":"","principal_investigators":null,"knowledge_user":"","client":"","objectives":"","results":"","availability_of_results":"","pia_approved":null,"infographic":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Outcomes after esophageal discontinuity: a population-based analysis of reversal rates and outcomes | ICES<\/title>\n<meta name=\"description\" content=\"Project ID: 2022-1028\/ TRIM 2025 0970 402 000 Project title: Outcomes after esophageal discontinuity: a population-based analysis of 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