{"id":14648,"date":"2023-05-25T22:36:36","date_gmt":"2023-05-26T02:36:36","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/?post_type=private_project&#038;p=14648"},"modified":"2025-02-28T11:22:17","modified_gmt":"2025-02-28T16:22:17","slug":"burden-of-illness-of-transfusion-dependent-beta-thalassemia-and-sickle-cell-disease-in-canada","status":"publish","type":"private_project","link":"https:\/\/www.ices.on.ca\/fr\/services-for-researchers\/all-projects\/private-sector-projects\/burden-of-illness-of-transfusion-dependent-beta-thalassemia-and-sickle-cell-disease-in-canada\/","title":{"rendered":"Burden of illness of sickle cell disease in Canada"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Client:<\/strong> IQVIA Solutions Canada Inc.<br><br><strong>Project ID: <\/strong>P2022-122A \/ 2023 0970 328 000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Research Question\/Objectives: <\/strong>Hemoglobinopathies represent a group of lifelong, autosomal recessive genetic disorders that affect the structure or production of hemoglobin (Hb) molecule. Sickle cell disease (SCD) is a group of hemoglobinopathies characterized by a \u201csickle shaped\u201d hemoglobin (HbS). Vaso-occlusive crises (VOC) are severe painful events that constitute the hallmark clinical feature of SCD, and are the leading cause of emergency department visits and hospitalizations for affected patients. Describing the treatment patterns, disease progression and healthcare resources utilization of patients with SCD will provide valuable evidence on the clinical and economic implications of SCD in Canada.<\/p>\n\n\n<p><strong>Feasibility Study Objectives <\/strong><\/p>\n<p><strong>Phase 1: <\/strong><\/p>\n<ol>\n<li>Identify sample sizes of SCD cohort<\/li>\n<li>Identify sample sizes of SCD patients with recurrent VOCs sub-group<\/li>\n<\/ol>\n<p><strong>Phase 2: <\/strong><\/p>\n<ol>\n<li>Describe baseline characteristics of cohorts and sub-groups<\/li>\n<li>Describe acute and chronic complications of cohorts and sub-groups<\/li>\n<li>Describe treatment patterns of cohorts and sub-groups<\/li>\n<\/ol>\n<p><strong>Status: <\/strong>Completed<\/p>\n<p><strong>Results: <\/strong>March 2025<\/p>","protected":false},"excerpt":{"rendered":"<p>Client: IQVIA Solutions Canada Inc. Project ID: P2022-122A \/ 2023 0970 328 000 Research Question\/Objectives: Hemoglobinopathies represent a group of lifelong, autosomal recessive genetic disorders that affect the structure or production of hemoglobin (Hb) molecule. Sickle cell disease (SCD) is a group of hemoglobinopathies characterized by a \u201csickle shaped\u201d hemoglobin (HbS). Vaso-occlusive crises (VOC) are [&hellip;]<\/p>\n","protected":false},"template":"","organization_type":[],"project_status":[105],"response_type":[],"class_list":["post-14648","private_project","type-private_project","status-publish","hentry","project_status-completed"],"acf":{"project_id":"P2022-122 \/ 2023 0970 328 000","project_id_year":2023,"ices_scientist":"","principal_investigators":null,"knowledge_user":"","client":"","objectives":"","results":"","availability_of_results":"","pia_approved":null,"infographic":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Burden of illness of sickle cell disease in Canada | ICES<\/title>\n<meta name=\"description\" content=\"Client: IQVIA Solutions Canada Inc.Project ID: P2022-122A \/ 2023 0970 328 000 Research Question\/Objectives: Hemoglobinopathies represent a group of\" 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