{"id":14647,"date":"2023-05-25T22:34:17","date_gmt":"2023-05-26T02:34:17","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/?post_type=private_project&#038;p=14647"},"modified":"2025-02-28T11:22:51","modified_gmt":"2025-02-28T16:22:51","slug":"an-observational-study-of-sickle-cell-disease-in-ontario-canada-healthcare-resource-utilization-and-clinical-outcomes","status":"publish","type":"private_project","link":"https:\/\/www.ices.on.ca\/fr\/services-for-researchers\/all-projects\/private-sector-projects\/an-observational-study-of-sickle-cell-disease-in-ontario-canada-healthcare-resource-utilization-and-clinical-outcomes\/","title":{"rendered":"An observational study of sickle cell disease in Ontario, Canada: healthcare resource utilization and clinical outcomes"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Client: <\/strong>IQVIA Solutions Canada Inc.<br><br><strong>Project ID: <\/strong>P2022-121 \/ 2023 0970 330 000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Research Question\/Objectives:<\/strong> The client seeks to investigate the true cost burden of sickle cell disease (SCD) to the Canadian healthcare system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Primary objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Describe the epidemiology of Ontarians with SCD, including incidence\/prevalence, patient demographic &amp; clinical characteristics, mortality.<\/li>\n\n\n\n<li>Study patient journey in terms of clinical history, treatment patterns and outcomes, healthcare use and costs.<\/li>\n\n\n\n<li>Assess the association between hemoglobin levels and other hemolytic biomarker on relevant clinical events (e.g., time to event analyses for endorgan damage, mortality, and other outcomes), costs and healthcare utilization.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Stratify the primary objectives by:\n<ul class=\"wp-block-list\">\n<li>Treatment received [such as hydroxyurea (HU) only, HU + transfusions, transfusions-only, transplants, opioids use, erythroid stimulating agents (ESAs), and iron chelation therapy (data availability and sample size permitting)]<\/li>\n\n\n\n<li>Patient characteristics\/outcomes (such as age)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Match the study cohort to general population controls to determine the difference in HCRU, costs, BOI and health outcomes.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Status:<\/strong> Completed<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Results: <\/strong>December 2024<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Client: IQVIA Solutions Canada Inc. Project ID: P2022-121 \/ 2023 0970 330 000 Research Question\/Objectives: The client seeks to investigate the true cost burden of sickle cell disease (SCD) to the Canadian healthcare system. Primary objectives: Secondary objectives: Status: Completed Results: December 2024<\/p>\n","protected":false},"template":"","organization_type":[],"project_status":[105],"response_type":[],"class_list":["post-14647","private_project","type-private_project","status-publish","hentry","project_status-completed"],"acf":{"project_id":"P2022-121 \/ 2023 0970 330 000","project_id_year":2023,"ices_scientist":"","principal_investigators":null,"knowledge_user":"","client":"","objectives":"","results":"","availability_of_results":"","pia_approved":null,"infographic":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>An observational study of sickle cell disease in Ontario, Canada: healthcare resource utilization and clinical outcomes | ICES<\/title>\n<meta name=\"description\" content=\"Client: IQVIA Solutions Canada Inc.Project ID: 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