{"id":14606,"date":"2023-05-25T21:36:07","date_gmt":"2023-05-26T01:36:07","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/?post_type=private_project&#038;p=14606"},"modified":"2025-02-28T13:55:26","modified_gmt":"2025-02-28T18:55:26","slug":"real-world-outcomes-and-costs-of-osteoporosis-fractures-in-ontario-canada","status":"publish","type":"private_project","link":"https:\/\/www.ices.on.ca\/fr\/services-for-researchers\/all-projects\/private-sector-projects\/real-world-outcomes-and-costs-of-osteoporosis-fractures-in-ontario-canada\/","title":{"rendered":"Real World Outcomes and Costs of Osteoporosis Fractures in Ontario, Canada"},"content":{"rendered":"\n<p><strong>Client:<\/strong> Amgen Canada Inc.<br><br><strong>Project ID:<\/strong> P2017-018 \/ 2018 0970 103 000<\/p>\n\n\n\n<p><strong>Research Question\/Objectives:<\/strong> Osteoporosis and the clinical fractures associated with the disease have significant consequences on human health and quality of life and represent a major burden to society. As with many other chronic and asymptomatic diseases, osteoporosis is under diagnosed and undertreated. The rates of treatment for osteoporosis are also sub-optimal, even among patients who have suffered hip or other fragility fractures. Studies conducted in a variety of different populations indicate that the rates of BMD testing and treatment following fragility fractures are generally &lt;50%, and often &lt;10%. The purpose of this study will be to describe the real-world management (including screening and treatment) and Health Resource Utilization (HRU) of patients subsequent to a primary fragility fracture in Ontario, Canada.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Objectives<\/h2>\n\n\n\n<p><strong>Primary Objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To describe the incidence of primary fragility fractures in patients over (65+).<\/li>\n\n\n\n<li>To describe the real-world management, including screening and treatment, and resource utilization following a primary fragility fracture.<\/li>\n<\/ul>\n\n\n\n<p><strong>Secondary Objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To characterize the publicly-insured Ontario fragility fracture patient.<\/li>\n\n\n\n<li>To describe patient management, including screening and treatment, prior to a fragility fracture in patients (65+).<\/li>\n\n\n\n<li>To describe the rate of subsequent fractures, related procedures, complications, hospitalizations and mortality subsequent to a primary fragility fracture.<\/li>\n<\/ul>\n\n\n\n<p><strong>Exploratory Objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To describe the persistence to osteoporosis treatments in patients (65+) who have had a fragility fracture.<\/li>\n\n\n\n<li>To describe comorbidities of interest and steroid-use in patients over (65+) who have had a fragility fracture.<\/li>\n\n\n\n<li>To describe opioid pain medications in patients (65+) prior to, and following a fragility fracture.<\/li>\n\n\n\n<li>To describe the HRU costs for matched patients who have not had a fragility fracture.<\/li>\n\n\n\n<li>To describe mortality for matched patients who have not had a fragility fracture.<\/li>\n<\/ul>\n\n\n\n<p><strong>Status<\/strong>: Completed<\/p>\n\n\n\n<p><strong>Results:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/05\/DCP-P2018-0970-103-000-Osteo-in-OntarioFINAL.docx\" data-type=\"URL\" data-id=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/05\/DCP-P2018-0970-103-000-Osteo-in-OntarioFINAL.docx\" target=\"_blank\" rel=\"noreferrer noopener\">Data set creation plan<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/05\/ICES-P0970-103-Amgen-OSTEO-Final-Deliverable.xlsx\" data-type=\"URL\" data-id=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/05\/ICES-P0970-103-Amgen-OSTEO-Final-Deliverable.xlsx\" target=\"_blank\" rel=\"noreferrer noopener\">Final deliverable<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Client: Amgen Canada Inc. Project ID: P2017-018 \/ 2018 0970 103 000 Research Question\/Objectives: Osteoporosis and the clinical fractures associated with the disease have significant consequences on human health and quality of life and represent a major burden to society. As with many other chronic and asymptomatic diseases, osteoporosis is under diagnosed and undertreated. The [&hellip;]<\/p>\n","protected":false},"template":"","organization_type":[],"project_status":[105],"response_type":[],"class_list":["post-14606","private_project","type-private_project","status-publish","hentry","project_status-completed"],"acf":{"project_id":"P2017-018 \/ 2018 0970 103 000","project_id_year":2017,"project_id_index":7,"ices_scientist":"","principal_investigators":null,"knowledge_user":"","client":"","objectives":"","results":"","availability_of_results":"","pia_approved":null,"infographic":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Real World Outcomes and Costs of Osteoporosis Fractures in Ontario, Canada | ICES<\/title>\n<meta name=\"description\" content=\"Client: Amgen Canada Inc.Project ID: P2017-018 \/ 2018 0970 103 000 Research Question\/Objectives: Osteoporosis and the clinical fractures 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