{"id":14604,"date":"2023-05-25T21:31:38","date_gmt":"2023-05-26T01:31:38","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/?post_type=private_project&#038;p=14604"},"modified":"2025-02-28T13:55:06","modified_gmt":"2025-02-28T18:55:06","slug":"burden-of-treatment-resistant-depression-in-ontario","status":"publish","type":"private_project","link":"https:\/\/www.ices.on.ca\/fr\/services-for-researchers\/all-projects\/private-sector-projects\/burden-of-treatment-resistant-depression-in-ontario\/","title":{"rendered":"Burden of treatment-resistant depression in Ontario"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Client:<\/strong> IMS Health | Brogan<br><br><strong>Project ID: <\/strong>P2016-008 \/ 2018 0970 105 000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Research Question\/Objectives: <\/strong>Refractory depression, also called treatment-resistant depression (TRD), is commonly encountered by mental health professionals, even in the context of treatment with appropriate anti-depressants. Up to two thirds of patients with major unipolar depression will not respond to the first medication prescribed and 10 &#8211; 33% will not respond to multiple interventions. General consensus is emerging that unipolar major depression is considered resistant or refractory when at least two trials with anti-depressants fail to produce a significant clinical improvement.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Primary objective:<\/strong> To measure the economic burden (direct costs) of TRD to the Ontario healthcare system compared to major depressive disorder (non-TRD) patient population and the general population.<br><br><strong>Secondary objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To describe the Ontario TRD patient population in terms of clinical and demographic characteristics<\/li>\n\n\n\n<li>To quantify the depression-related healthcare resource utilization (HCRU) of TRD patients in Ontario compared to the non-TRD patient population and to the general population<\/li>\n\n\n\n<li>To measure incremental HCRU and incremental costs of TRD patients by the number of anti-depressant failures<\/li>\n\n\n\n<li>To determine the average number of failed anti-depressant lines before MDD patients progress to an electroconvulsive therapy (ETC).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Status<\/strong>: Completed<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Results:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Data set creation plan \u2014 pending<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/08\/DAS-2018-0970-105-000-Final-Report-20181101.xlsx\" data-type=\"URL\" data-id=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/05\/DAS-970-100-000-Deliverables-Report-FINAL.xlsx\" target=\"_blank\" rel=\"noreferrer noopener\">Final deliverable<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Client: IMS Health | Brogan Project ID: P2016-008 \/ 2018 0970 105 000 Research Question\/Objectives: Refractory depression, also called treatment-resistant depression (TRD), is commonly encountered by mental health professionals, even in the context of treatment with appropriate anti-depressants. Up to two thirds of patients with major unipolar depression will not respond to the first medication [&hellip;]<\/p>\n","protected":false},"template":"","organization_type":[],"project_status":[105],"response_type":[],"class_list":["post-14604","private_project","type-private_project","status-publish","hentry","project_status-completed"],"acf":{"project_id":"P2016-008 \/ 2018 0970 105 000","project_id_year":2017,"ices_scientist":"","principal_investigators":null,"knowledge_user":"","client":"","objectives":"","results":"","availability_of_results":"","pia_approved":null,"infographic":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Burden of treatment-resistant depression in Ontario | ICES<\/title>\n<meta name=\"description\" content=\"Client: IMS Health | BroganProject ID: P2016-008 \/ 2018 0970 105 000 Research 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