{"id":7993,"date":"2019-11-26T00:00:00","date_gmt":"2019-11-26T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/news-releases\/death-risk-up-to-12-times-higher-for-mothers-with-prenatal-opioid-use\/"},"modified":"2023-06-14T18:13:08","modified_gmt":"2023-06-14T22:13:08","slug":"death-risk-up-to-12-times-higher-for-mothers-with-prenatal-opioid-use","status":"publish","type":"news_release","link":"https:\/\/www.ices.on.ca\/fr\/news-releases\/death-risk-up-to-12-times-higher-for-mothers-with-prenatal-opioid-use\/","title":{"rendered":"Death risk up to 12 times higher for mothers with prenatal opioid use"},"content":{"rendered":"<p>Approximately one in 20 mothers whose babies are born with neonatal abstinence syndrome (NAS) died within 10 years of delivery in both England and Canada, according to a new study from researchers at ICES, The Hospital for Sick Children (SickKids) and UCL.<\/p>\n<p>\nNeonatal abstinence syndrome (also called NAS) is a group of symptoms experienced by babies from withdrawal from certain drugs (predominantly opioids) that they are exposed to in the womb before birth. It is also a widely used measure of material use of opioids during pregnancy.<\/p>\n<div>\n<div class=\"download-section alignwide infographic-download\" id=\"block_bc719abd284ac3677e93fe7b9b0b8b68\" data-style=\"deep-blue\">\n\t<div class=\"download-section-content\">\n\t\t\t\t<h2>\n\t\t\tInfographic\t\t<\/h2>\n\t\t\n\t\t\t<\/div>\n\t<div class=\"download-section-buttons\">\n\t\t\t\t\t\t<a class=\"download-section-buttons-primary\" href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/03\/GuttmanMaternalOpioids.jpg\" target=\"_blank\"\n\t\t\tdownload\t\t\taria-label=\"Download Infographic (opens in a new tab)\"\t\t>\n\t\t\tDownload Infographic\t\t\t<svg width=\"19\" height=\"19\" viewBox=\"0 0 19 19\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" role=\"presentation\">\n<path d=\"M2.78003 18.8301C2.14282 18.8301 1.59713 18.603 1.14297 18.1488C0.688813 17.6947 0.46212 17.1494 0.462893 16.5129V13.0372H2.78003V16.5129H16.6829V13.0372H19V16.5129C19 17.1502 18.7729 17.6958 18.3188 18.15C17.8646 18.6042 17.3193 18.8308 16.6829 18.8301H2.78003ZM9.73145 14.1958L3.9386 8.40295L5.5606 6.72303L8.57288 9.73531V0.292969H10.89V9.73531L13.9023 6.72303L15.5243 8.40295L9.73145 14.1958Z\" fill=\"#151D5D\"\/>\n<\/svg>\n\t\t<\/a>\n\t\t\n\t\t\t\t\t\t\t\t\t\t<button type=\"button\" class=\"download-section-buttons-secondary\" data-infographic-popup-open=\"block_bc719abd284ac3677e93fe7b9b0b8b68-infographic-popup\" aria-haspopup=\"dialog\">\n\t\t\t\tClick to View\t\t\t<\/button>\n\t\t\t\t\t\t<\/div>\n\n\t\t<div class=\"infographic-popup\" id=\"block_bc719abd284ac3677e93fe7b9b0b8b68-infographic-popup\" role=\"dialog\" aria-modal=\"true\" aria-label=\"Infographic\" hidden>\n\t\t<div class=\"infographic-popup-overlay\" data-infographic-popup-close><\/div>\n\t\t<div class=\"infographic-popup-container\">\n\t\t\t<button type=\"button\" class=\"infographic-popup-close\" data-infographic-popup-close aria-label=\"Close infographic\">&times;<\/button>\n\t\t\t<img decoding=\"async\" class=\"infographic-popup-image\" src=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/03\/GuttmanMaternalOpioids.jpg\" alt=\"Infographic\">\n\t\t<\/div>\n\t<\/div>\n\t<\/div>\n<\/div>\n<p>\nThe study published today in <em>PLOS Medicine<\/em>, looked at data that included all hospital births in England and in Ontario, Canada from 2002 to 2012 and analyzed death rates through to 2016. The researchers examined data on 13,577 mothers in England and 4,966 in Ontario with infants with NAS and compared it to 4,205,675 mothers in England and 929,985 in Ontario whose infants did not have NAS.<\/p>\n<p>\nThe researchers found that at 10 years after giving birth, 5.1 per cent of English mothers with infants with NAS and 4.6 per cent of Ontarian mothers had died compared with 0.4 per cent of mothers whose infants did not have NAS in both countries. This translates to an 11 to 12 times higher risk of death associated with prenatal opioid use. The majority of deaths in mothers with infants with NAS were from avoidable causes such as intentional and unintentional injuries.&#xa0;<\/p>\n<p>Opioids are now a leading cause of death of young and middle-aged people in North America and rates of use and misuse are also increasing in the United Kingdom. There has been a steep increase in the number of women who use opioids during pregnancy, which can result in their infants having signs of NAS. Most studies of NAS focus on the child&#x2019;s health, with very few about the mother&#x2019;s health.<\/p>\n<p>\n&#x201c;Pregnancy care is an opportunity to identify mothers who may need addiction services and other support to improve their health and that of their families&#x201d; says <a href=\"\/ices-scientists\/astrid-guttmann\/\">Dr. Astrid Guttmann<\/a>, primary author on the study, chief science officer at ICES, staff paediatrician and senior associate scientist at SickKids and professor of paediatrics with a cross appointment in Health Policy, Management and Evaluation and the Epidemiology Division at the Dalla Lana School of Public Health at the University of Toronto.&#xa0;<\/p>\n<p>&#x201c;We were struck by how consistent the findings were in both England and Canada. This is despite differences in the profile of opioid users in England and Canada suggesting both countries need to focus on improving long-term care for mothers with opioid addiction,&#x201d; says Dr. Ruth Blackburn, co-primary author and UKRI innovation fellow at the UCL Institute of Health Informatics in London, England.&#xa0;<\/p>\n<p>\nThe researchers also found that mothers with infants with versus without NAS were more likely to live in poverty, have other mental health and addiction disorders and have their infants placed in out of home care.<\/p>\n<p>\nThe researchers add that policymakers focused on harm reduction related to opioid use should include a focus on pregnant mothers and their children; public health programs such as nurse home visitors need to extend past the current period of only one to two years after birth.<\/p>\n<p>\nUCL and the University of Toronto, including SickKids and other affiliated hospitals, are strategic global partners working together to address a range of global challenges. The partnership is built on more than 30 established collaboration in fields such as health sciences, city building and education, with new research collaborations being developed in areas with important implications, such as artificial intelligence and nanotechnology.<\/p>\n<p>\n&#x201c;Long-term mortality in mothers of infants with neonatal abstinence syndrome: a population-based parallel-cohort study in England and Ontario, Canada,&#x201d; was published November 26, 2019 in <em>PLOS Medicine<\/em>.<\/p>\n<p><em><br \/>\nAuthor block: Astrid Guttmann, Ruth Blackburn, Abby Amartey, Limei Zhou, Linda Wijlaars, Natasha Saunders, Katie Harron, Maria Chiu and Ruth Gilbert.<\/em><\/p>\n<div><div class=\"about-ices-shortcode\"><p><strong>ICES<\/strong> is an independent, non-profit research institute that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. In October 2018, the institute formerly known as the Institute for Clinical Evaluative Sciences formally adopted the initialism ICES as its official name. For the latest ICES news, follow us on Twitter: <a href=\"https:\/\/twitter.com\/ICESOntario\" target=\"_blank\" rel=\"noopener\">@ICESOntario<\/a><\/p>\n<\/div><\/div>\n<p><span class=\"bold\">About The Hospital for Sick Children (SickKids)<\/span><br \/>\nThe Hospital for Sick Children (SickKids) is recognized as one of the world&#x2019;s foremost paediatric health-care institutions and is Canada&#x2019;s leading centre dedicated to advancing children&#x2019;s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada&#x2019;s most research-intensive hospitals and has generated discoveries that have helped children globally. Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system. SickKids is a founding member of Kids Health Alliance, a network of partners working to create a high quality, consistent and coordinated approach to pediatric healthcare that is centred around children, youth and their families. SickKids is proud of its vision for Healthier Children. A Better World. For more information, please visit <a href=\"http:\/\/www.sickkids.ca\" title=\"opens external link\">www.sickkids.ca<\/a>. Follow us on Twitter (<a href=\"https:\/\/twitter.com\/SickKidsNews\" title=\"opens external link\">@SickKidsNews<\/a>) and Instagram (<a href=\"https:\/\/www.instagram.com\/sickkidstoronto\" title=\"opens external link\">@SickKidsToronto<\/a>).<\/p>\n<p><strong><br \/>\nUCL &#x2013; London&#x2019;s Global University<\/strong><br \/>\nUCL is a diverse community with the freedom to challenge and think differently.<\/p>\n<p>\nOur community of more than 41,500 students from 150 countries and over 12,500 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.<\/p>\n<p>\nWe are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.&#xa0;<\/p>\n<p>\nWe have a progressive and integrated approach to our teaching and research &#x2013; championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.<\/p>\n<p>For almost 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.&#xa0;<\/p>\n<p>\nWe were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.<\/p>\n<p>\n<a href=\"http:\/\/www.ucl.ac.uk\" title=\"opens external link\">www.ucl.ac.uk<\/a>| Follow <a href=\"https:\/\/twitter.com\/uclnews\" title=\"opens external link\">@uclnews<\/a> on Twitter | Watch our YouTube channel | Listen to UCL podcasts on SoundCloud | Find out what&#x2019;s on at UCL Minds | #MadeAtUCL<\/p>\n<p><em><br \/>\nRuth Blackburn is supported by a UKRI Innovation Fellowship funded by the Medical Research Council (Grant No: MR\/S003797\/1) and both Ruth Blackburn and Ruth Gilbert benefit from the Health Data Research UK, an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities. This work also benefitted from the National Institute for Health Research (NIHR) Policy Research Programme and supported by the Administrative Data Research Centre for England by the Economic and Social Research Council, and infrastructure funded by the NIHR GOS BRC.<\/em><\/p>\n<h2>\nFOR FURTHER INFORMATION PLEASE CONTACT:<\/h2>\n<p>\nDeborah Creatura<br \/>\nMedia Advisor, ICES<br \/>\n<a href=\"mailto:deborah.creatura@ices.on.ca\">deborah.creatura@ices.on.ca<\/a><br \/>\n(o) 416-480-4780 or (c) 647-406-5996<\/p>\n<p>&#xa0;<\/p>\n<p>\nSasha Babakhanova<br \/>\nThe Hospital for Sick Children (SickKids)<br \/>\n<a href=\"mailto:sasha.babakhanova@sickkids.ca\">sasha.babakhanova@sickkids.ca<\/a>&#xa0; &#xa0;<br \/>\n416-813-7654 ext 228469<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Approximately one in 20 mothers whose babies are born with neonatal abstinence syndrome (NAS) died within 10 years of delivery in both England and Canada, according to a new study from researchers at ICES, The Hospital for Sick Children (SickKids) and UCL. Neonatal abstinence syndrome (also called NAS) is a group of symptoms experienced by [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[26,56,21],"class_list":["post-7993","news_release","type-news_release","status-publish","hentry","topic-maternity-and-neonatal-care","topic-pharmacoepidemiology-and-drug-safety","topic-women-or-gender-based-research"],"acf":{"infographic":[9543],"journal_article":[5632],"research_report":[],"atlas":[],"research_program":[6740],"site":[6733],"ices_scientist":[1238],"announce_or_event":[],"video":[],"iitn_type":false,"iitn_title":"Prenatal opioid use linked to increased mortality for moms","iitn_short_title":"","iitn_source_link_url":"https:\/\/www.medscape.com\/viewarticle\/921904#vp_1","iitn_source_link_text":"Medscape","sitecore_item_id":"8F45B22E-DA3F-43CB-9708-150A4E9A0D34","sitecore_item_name":"Death-risk-up-to-12-times-higher-for-mothers-with-prenatal-opioid-use","sitecore_field_values":"{\n  \"Content\": \"<p>Approximately one in 20 mothers whose babies are born with neonatal abstinence syndrome (NAS) died within 10 years of delivery in both England and Canada, according to a new study from researchers at ICES, The Hospital for Sick Children (SickKids) and UCL.<\/p>n<p>nNeonatal abstinence syndrome (also called NAS) is a group of symptoms experienced by babies from withdrawal from certain drugs (predominantly opioids) that they are exposed to in the womb before birth. It is also a widely used measure of material use of opioids during pregnancy.<\/p>n<p><a href=\"~\/media\/51916104B8354EE4A9D493151BA9C6F2.ashx\" onclick=\"_gaq.push(['_trackEvent','Download', 'IndigenousDiabetesReportInfographicNovember2019',this.href]);\"><img height=\"204\" alt=\"Women who give birth to babies with neonatal abstinence syndrome much more likely to die young\" width=\"350\" src=\"~\/media\/8751916E87F94DF283849A8A02C3C6F8.ashx\" \/><\/a><br \/>n<span class=\"grey\" style=\"font-size: 12px; font-weight: bold; display: block; color: #5b5656;\">Click image to enlarge<\/span><\/p>n<p>nThe study published today in <em>PLOS Medicine<\/em>, looked at data that included all hospital births in England and in Ontario, Canada from 2002 to 2012 and analyzed death rates through to 2016. The researchers examined data on 13,577 mothers in England and 4,966 in Ontario with infants with NAS and compared it to 4,205,675 mothers in England and 929,985 in Ontario whose infants did not have NAS.<\/p>n<p>nThe researchers found that at 10 years after giving birth, 5.1 per cent of English mothers with infants with NAS and 4.6 per cent of Ontarian mothers had died compared with 0.4 per cent of mothers whose infants did not have NAS in both countries. This translates to an 11 to 12 times higher risk of death associated with prenatal opioid use. The majority of deaths in mothers with infants with NAS were from avoidable causes such as intentional and unintentional injuries.&nbsp;<\/p>n<p>Opioids are now a leading cause of death of young and middle-aged people in North America and rates of use and misuse are also increasing in the United Kingdom. There has been a steep increase in the number of women who use opioids during pregnancy, which can result in their infants having signs of NAS. Most studies of NAS focus on the child&rsquo;s health, with very few about the mother&rsquo;s health.<\/p>n<p>n&ldquo;Pregnancy care is an opportunity to identify mothers who may need addiction services and other support to improve their health and that of their families&rdquo; says <a href=\"~\/link.aspx?_id=DF9D6D4F1B334FB9AD9B576798163C2C&amp;_z=z\">Dr. Astrid Guttmann<\/a>, primary author on the study, chief science officer at ICES, staff paediatrician and senior associate scientist at SickKids and professor of paediatrics with a cross appointment in Health Policy, Management and Evaluation and the Epidemiology Division at the Dalla Lana School of Public Health at the University of Toronto.&nbsp;<\/p>n<p>&ldquo;We were struck by how consistent the findings were in both England and Canada. This is despite differences in the profile of opioid users in England and Canada suggesting both countries need to focus on improving long-term care for mothers with opioid addiction,&rdquo; says Dr. Ruth Blackburn, co-primary author and UKRI innovation fellow at the UCL Institute of Health Informatics in London, England.&nbsp;<\/p>n<p>nThe researchers also found that mothers with infants with versus without NAS were more likely to live in poverty, have other mental health and addiction disorders and have their infants placed in out of home care.<\/p>n<p>nThe researchers add that policymakers focused on harm reduction related to opioid use should include a focus on pregnant mothers and their children; public health programs such as nurse home visitors need to extend past the current period of only one to two years after birth.<\/p>n<p>nUCL and the University of Toronto, including SickKids and other affiliated hospitals, are strategic global partners working together to address a range of global challenges. The partnership is built on more than 30 established collaboration in fields such as health sciences, city building and education, with new research collaborations being developed in areas with important implications, such as artificial intelligence and nanotechnology.<\/p>n<p>n&ldquo;Long-term mortality in mothers of infants with neonatal abstinence syndrome: a population-based parallel-cohort study in England and Ontario, Canada,&rdquo; was published November 26, 2019 in <em>PLOS Medicine<\/em>.<\/p>n<p><em>nAuthor block: Astrid Guttmann, Ruth Blackburn, Abby Amartey, Limei Zhou, Linda Wijlaars, Natasha Saunders, Katie Harron, Maria Chiu and Ruth Gilbert.<\/em><\/p>n<p><em><span style=\"color: #002060;\">ICES is an independent, non-profit research institute that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. In October 2018, the institute formerly known as the Institute for Clinical Evaluative Sciences formally adopted the initialism ICES as its official name. For the latest ICES news, follow us on Twitter: <a href=\"http:\/\/www.twitter.com\/ICESOntario\">@ICESOntario<\/a><\/span><\/em><\/p>n<p><span class=\"bold\">About The Hospital for Sick Children (SickKids)<\/span><br \/>nThe Hospital for Sick Children (SickKids) is recognized as one of the world&rsquo;s foremost paediatric health-care institutions and is Canada&rsquo;s leading centre dedicated to advancing children&rsquo;s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada&rsquo;s most research-intensive hospitals and has generated discoveries that have helped children globally. Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system. SickKids is a founding member of Kids Health Alliance, a network of partners working to create a high quality, consistent and coordinated approach to pediatric healthcare that is centred around children, youth and their families. SickKids is proud of its vision for Healthier Children. A Better World. For more information, please visit <a href=\"http:\/\/www.sickkids.ca\" title=\"opens external link\">www.sickkids.ca<\/a>. Follow us on Twitter (<a href=\"https:\/\/twitter.com\/SickKidsNews\" title=\"opens external link\">@SickKidsNews<\/a>) and Instagram (<a href=\"https:\/\/www.instagram.com\/sickkidstoronto\" title=\"opens external link\">@SickKidsToronto<\/a>).<\/p>n<p><strong>nUCL &ndash; London&rsquo;s Global University<\/strong><br \/>nUCL is a diverse community with the freedom to challenge and think differently.<\/p>n<p>nOur community of more than 41,500 students from 150 countries and over 12,500 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.<\/p>n<p>nWe are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.&nbsp;<\/p>n<p>nWe have a progressive and integrated approach to our teaching and research &ndash; championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.<\/p>n<p>For almost 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.&nbsp;<\/p>n<p>nWe were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.<\/p>n<p>n<a href=\"http:\/\/www.ucl.ac.uk\" title=\"opens external link\">www.ucl.ac.uk<\/a>| Follow <a href=\"https:\/\/twitter.com\/uclnews\" title=\"opens external link\">@uclnews<\/a> on Twitter | Watch our YouTube channel | Listen to UCL podcasts on SoundCloud | Find out what&rsquo;s on at UCL Minds | #MadeAtUCL<\/p>n<p><em>nRuth Blackburn is supported by a UKRI Innovation Fellowship funded by the Medical Research Council (Grant No: MR\/S003797\/1) and both Ruth Blackburn and Ruth Gilbert benefit from the Health Data Research UK, an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities. This work also benefitted from the National Institute for Health Research (NIHR) Policy Research Programme and supported by the Administrative Data Research Centre for England by the Economic and Social Research Council, and infrastructure funded by the NIHR GOS BRC.<\/em><\/p>n<h2>nFOR FURTHER INFORMATION PLEASE CONTACT:<\/h2>n<p>nDeborah Creatura<br \/>nMedia Advisor, ICES<br \/>n<a href=\"mailto:deborah.creatura@ices.on.ca\">deborah.creatura@ices.on.ca<\/a><br \/>n(o) 416-480-4780 or (c) 647-406-5996<\/p>n&nbsp;n<p>nSasha Babakhanova<br \/>nThe Hospital for Sick Children (SickKids)<br \/>n<a href=\"mailto:sasha.babakhanova@sickkids.ca\">sasha.babakhanova@sickkids.ca<\/a>&nbsp; &nbsp;<br \/>n416-813-7654 ext 228469<\/p>\",\n  \"Title\": \"Death risk up to 12 times higher for mothers with prenatal opioid use\",\n  \"Short title\": \"Death risk up to 12 times higher for\",\n  \"Teaser image\": \"<image mediaid=\"{A322F4BD-074D-4BD9-A21A-A9A358DE2CFF}\" alt=\"&quot;&quot;\" height=\"\" width=\"\" hspace=\"\" vspace=\"\" \/>\",\n  \"Summary\": \"Approximately one in 20 mothers whose babies are born with neonatal abstinence syndrome (NAS) died within 10 years of delivery in both England and Canada.\",\n  \"Location\": \"Toronto\",\n  \"In The News\": \"{E6CA8E99-87B4-4701-B379-670C9D77560C}\",\n  \"ICES Scientists\": \"{DF9D6D4F-1B33-4FB9-AD9B-576798163C2C}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"Research Programs\": \"{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"Posted Date\": \"20191126T000000\",\n  \"Publication Link\": \"<link text=\"Abstract\" linktype=\"internal\" title=\"opens related abstract\" querystring=\"\" target=\"\" id=\"{84909485-3FDE-4427-9750-5C8C8F023887}\" \/>\",\n  \"Related Link\": \"<link text=\"Infographic\" linktype=\"external\" url=\"~\/Publications\/Infographics?year=2019&amp;page=1#GuttmannMaternalOpioids\" anchor=\"\" title=\"opens related infographic\" target=\"\" \/>\",\n  \"Related Link2\": \"<link text=\"ICES in the News | Medscape\" linktype=\"external\" url=\"https:\/\/www.medscape.com\/viewarticle\/921904#vp_1\" anchor=\"\" title=\"opens external link\" target=\"\" \/>\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Newsroom\/News-Releases\/2019\/Death-risk-up-to-12-times-higher-for-mothers-with-prenatal-opioid-use"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Death risk up to 12 times higher for mothers with prenatal opioid use<\/title>\n<meta name=\"description\" content=\"Approximately one in 20 mothers whose babies are born with neonatal abstinence syndrome (NAS) died within 10 years of delivery in both England and Canada,\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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