{"id":7672,"date":"2016-10-31T00:00:00","date_gmt":"2016-10-31T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/news-releases\/big-data-study-shows-good-cholesterol-not-the-best-marker-for-heart-health\/"},"modified":"2023-06-14T18:17:00","modified_gmt":"2023-06-14T22:17:00","slug":"big-data-study-shows-good-cholesterol-not-the-best-marker-for-heart-health","status":"publish","type":"news_release","link":"https:\/\/www.ices.on.ca\/fr\/news-releases\/big-data-study-shows-good-cholesterol-not-the-best-marker-for-heart-health\/","title":{"rendered":"Big data study shows \u201cgood\u201d cholesterol not the best marker for heart health"},"content":{"rendered":"<p>Elevated high-density lipoprotein (HDL) cholesterol levels have long been praised as a way of reducing or eliminating heart disease but a large-scale study from the<b> Institute for Clinical Evaluative Sciences (ICES)<\/b> shows HDL or &#x201c;good&#x201d; cholesterol isn&#x2019;t a specific marker for heart health.<\/p>\n<p>&#x201c;Our study shows that rising HDL cholesterol levels are not the Holy Grail for heart health as we were made to believe for a long time. This may be the reason why drugs that increase HDL levels have not led to improved heart outcomes,&#x201d; says the study&#x2019;s lead author <a href=\"\/ices-scientists\/dennis-ko\/\">Dr. Dennis Ko<\/a>, who is a scientist at ICES and an interventional cardiologist at Schulich Heart Centre, Sunnybrook Health Sciences Centre.<\/p>\n<div>\n<div class=\"download-section alignwide infographic-download\" id=\"block_9060d16eacac15188f44380f96c6a71b\" data-style=\"deep-blue\">\n\t<div class=\"download-section-content\">\n\t\t\t\t<h2>\n\t\t\tInfographic\t\t<\/h2>\n\t\t\n\t\t\t<\/div>\n\t<div class=\"download-section-buttons\">\n\t\t\t\t\t\t<a class=\"download-section-buttons-primary\" href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/03\/KoHDLFIN.png\" target=\"_blank\"\n\t\t\tdownload\t\t\taria-label=\"Download Infographic (opens in a new tab)\"\t\t>\n\t\t\tDownload Infographic\t\t\t<svg width=\"19\" height=\"19\" viewBox=\"0 0 19 19\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" role=\"presentation\">\n<path d=\"M2.78003 18.8301C2.14282 18.8301 1.59713 18.603 1.14297 18.1488C0.688813 17.6947 0.46212 17.1494 0.462893 16.5129V13.0372H2.78003V16.5129H16.6829V13.0372H19V16.5129C19 17.1502 18.7729 17.6958 18.3188 18.15C17.8646 18.6042 17.3193 18.8308 16.6829 18.8301H2.78003ZM9.73145 14.1958L3.9386 8.40295L5.5606 6.72303L8.57288 9.73531V0.292969H10.89V9.73531L13.9023 6.72303L15.5243 8.40295L9.73145 14.1958Z\" fill=\"#151D5D\"\/>\n<\/svg>\n\t\t<\/a>\n\t\t\n\t\t\t\t\t\t\t\t\t\t<button type=\"button\" class=\"download-section-buttons-secondary\" data-infographic-popup-open=\"block_9060d16eacac15188f44380f96c6a71b-infographic-popup\" aria-haspopup=\"dialog\">\n\t\t\t\tClick to View\t\t\t<\/button>\n\t\t\t\t\t\t<\/div>\n\n\t\t<div class=\"infographic-popup\" id=\"block_9060d16eacac15188f44380f96c6a71b-infographic-popup\" role=\"dialog\" aria-modal=\"true\" aria-label=\"Infographic\" hidden>\n\t\t<div class=\"infographic-popup-overlay\" data-infographic-popup-close><\/div>\n\t\t<div class=\"infographic-popup-container\">\n\t\t\t<button type=\"button\" class=\"infographic-popup-close\" data-infographic-popup-close aria-label=\"Close infographic\">&times;<\/button>\n\t\t\t<img decoding=\"async\" class=\"infographic-popup-image\" src=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/03\/KoHDLFIN.png\" alt=\"Infographic\">\n\t\t<\/div>\n\t<\/div>\n\t<\/div>\n<\/div>\n<p>In the study, the researchers refer to the inability of recent randomized trials to improve clinical outcomes by targeting a rise in HDL cholesterol levels, which has challenged the conventional wisdom that higher HDL levels improve cardiovascular health.<\/p>\n<p>&#x201c;Our findings suggest that the HDL cholesterol level is not specific to the heart but instead a marker of general health. As such, it may not be an independent modifiable risk factor for cardiovascular disease,&#x201d; adds Ko.<\/p>\n<p>The researchers examined the relationship of HDL cholesterol levels and cause-specific outcomes in more than 630,000 Ontarians without pre-existing cardiovascular conditions.<\/p>\n<p>The study published today in the <i>Journal of the American College of Cardiology <\/i>is the largest population-based study to evaluate the association between the full range of HDL cholesterol levels and cardiovascular and non-cardiovascular deaths in individuals living in the same environment and exposed to the same healthcare system.<\/p>\n<p>&#x201c;We need a change in mindset. Our data does not show that super-high HDL levels reduce the risk further. Instead of only focusing on HDL levels, we also need to focus on improving modifiable risk factors,&#x201d; says Ko.<\/p>\n<p>The study found individuals with lower HDL cholesterol levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors and medical comorbidities. Lower HDL cholesterol levels were independently associated with higher risk of cardiovascular, cancer, and other mortality compared with individual in the reference ranges of HDL cholesterol levels.<\/p>\n<p>This project is part of the CANHEART (<a href=\"http:\/\/www.canheart.ca\" title=\"External link opens in new window\" target=\"_blank\" rel=\"noopener\">www.canheart.ca<\/a>) &#x2018;big data&#x2019; initiative, funded by the Institute for Circulatory and Respiratory Health-Canadian Institutes of Health Research.<\/p>\n<p>&#x201c;High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions&#x201d; was published today in the <i>Journal of the American College of Cardiology.<\/i><\/p>\n<p><i>Author block: <\/i><i>Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, Tu JV.<\/i><\/p>\n<p><em><span style=\"color: #002060;\"><span class=\"bold\">The Institute for Clinical Evaluative Sciences (ICES)<\/span> is an independent, non-profit organization that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. For the latest ICES news, follow us on Twitter: <a href=\"http:\/\/www.twitter.com\/icesontario\" title=\"Twitter link opens in new window\" target=\"_blank\" rel=\"noopener\">@ICESOntario<\/a><\/span><\/em><\/p>\n<h2>FOR FURTHER INFORMATION PLEASE CONTACT:<\/h2>\n<p>Deborah Creatura<br \/>\nMedia Advisor, ICES<br \/>\n<a href=\"mailto:deborah.creatura@ices.on.ca\">deborah.creatura@ices.on.ca<\/a><br \/>\n(o) 416-480-4780 or (c) 647-406-5996<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elevated high-density lipoprotein (HDL) cholesterol levels have long been praised as a way of reducing or eliminating heart disease but a large-scale study from the Institute for Clinical Evaluative Sciences (ICES) shows HDL or &#x201c;good&#x201d; cholesterol isn&#x2019;t a specific marker for heart health. &#x201c;Our study shows that rising HDL cholesterol levels are not the Holy [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,60],"class_list":["post-7672","news_release","type-news_release","status-publish","hentry","topic-cardiovascular-disease","topic-policy-and-program-evaluation"],"acf":{"infographic":[9306],"journal_article":[6485,6485],"research_report":[],"atlas":[],"research_program":[6742],"site":[6733],"ices_scientist":[1146],"announce_or_event":[],"video":[],"iitn_type":false,"iitn_title":"Does \u2018good\u2019 cholesterol still matter?","iitn_short_title":"","iitn_source_link_url":"https:\/\/www.washingtonpost.com\/national\/health-science\/does-good-cholesterol-still-matter\/2017\/05\/26\/d6926a8a-0e69-11e7-9b0d-d27c98455440_story.html?utm_term=.ca00bb7493c4","iitn_source_link_text":"The Washington Post","sitecore_item_id":"6AA5E6AC-9FBE-45E9-82C0-8A0409A17D00","sitecore_item_name":"Big-data-study-shows-good-cholesterol-not-the-best-marker-for-heart-health","sitecore_field_values":"{\n  \"Content\": \"<p>Elevated high-density lipoprotein (HDL) cholesterol levels have long been praised as a way of reducing or eliminating heart disease but a large-scale study from the<b> Institute for Clinical Evaluative Sciences (ICES)<\/b> shows HDL or &ldquo;good&rdquo; cholesterol isn&rsquo;t a specific marker for heart health.<\/p>rn<p>&ldquo;Our study shows that rising HDL cholesterol levels are not the Holy Grail for heart health as we were made to believe for a long time. This may be the reason why drugs that increase HDL levels have not led to improved heart outcomes,&rdquo; says the study&rsquo;s lead author <a href=\"~\/link.aspx?_id=B382715293D14FB2B106590CB331A264&amp;_z=z\">Dr. Dennis Ko<\/a>, who is a scientist at ICES and an interventional cardiologist at Schulich Heart Centre, Sunnybrook Health Sciences Centre.<\/p>rn<p><a href=\"~\/media\/F78CE7BA10294EAD9BB6F183FAD3A7C8.ashx\" onclick=\"_gaq.push(['_trackEvent','Download','GoodCholesterolNotBestMarkerInfographicOct2016',this.href]);\" target=\"_blank\"><img width=\"350\" height=\"231\" alt=\"Too much of a &quot;good&quot; thing\" src=\"~\/media\/FC46DCC075594A008FFB3E10E551EFA9.ashx\" width=\"350\" height=\"231\" \/><\/a><span class=\"grey\" style=\"font-size: 12px; font-weight: bold; color: #5b5656; display: block;\">Click image to enlarge<\/span><\/p>rn<p>In the study, the researchers refer to the inability of recent randomized trials to improve clinical outcomes by targeting a rise in HDL cholesterol levels, which has challenged the conventional wisdom that higher HDL levels improve cardiovascular health.<\/p>rn<p>&ldquo;Our findings suggest that the HDL cholesterol level is not specific to the heart but instead a marker of general health. As such, it may not be an independent modifiable risk factor for cardiovascular disease,&rdquo; adds Ko.<\/p>rn<p>The researchers examined the relationship of HDL cholesterol levels and cause-specific outcomes in more than 630,000 Ontarians without pre-existing cardiovascular conditions.<\/p>rn<p>The study published today in the <i>Journal of the American College of Cardiology <\/i>is the largest population-based study to evaluate the association between the full range of HDL cholesterol levels and cardiovascular and non-cardiovascular deaths in individuals living in the same environment and exposed to the same healthcare system.<\/p>rn<p>&ldquo;We need a change in mindset. Our data does not show that super-high HDL levels reduce the risk further. Instead of only focusing on HDL levels, we also need to focus on improving modifiable risk factors,&rdquo; says Ko.<\/p>rn<p>The study found individuals with lower HDL cholesterol levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors and medical comorbidities. Lower HDL cholesterol levels were independently associated with higher risk of cardiovascular, cancer, and other mortality compared with individual in the reference ranges of HDL cholesterol levels.<\/p>rn<p>This project is part of the CANHEART (<a href=\"http:\/\/www.canheart.ca\" title=\"External link opens in new window\" target=\"_blank\">www.canheart.ca<\/a>) &lsquo;big data&rsquo; initiative, funded by the Institute for Circulatory and Respiratory Health-Canadian Institutes of Health Research.<\/p>rn<p>&ldquo;High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions&rdquo; was published today in the <i>Journal of the American College of Cardiology.<\/i><\/p>rn<p><i>Author block: <\/i><i>Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, Tu JV.<\/i><\/p>rn<p><em><span style=\"color: #002060;\"><span class=\"bold\">The Institute for Clinical Evaluative Sciences (ICES)<\/span> is an independent, non-profit organization that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad, and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. For the latest ICES news, follow us on Twitter: <a href=\"http:\/\/www.twitter.com\/icesontario\" title=\"Twitter link opens in new window\" target=\"_blank\">@ICESOntario<\/a><\/span><\/em><\/p>rn<h2>FOR FURTHER INFORMATION PLEASE CONTACT:<\/h2>rn<p>Deborah Creatura<br \/>rnMedia Advisor, ICES<br \/>rn<a href=\"mailto:deborah.creatura@ices.on.ca\">deborah.creatura@ices.on.ca<\/a><br \/>rn(o) 416-480-4780 or (c) 647-406-5996<\/p>\",\n  \"Title\": \"Big data study shows \u201cgood\u201d cholesterol not the best marker for heart health\",\n  \"Short title\": \"Big data study shows \u201cgood\u201d cholesterol\",\n  \"Teaser image\": \"<image mediaid=\"{A322F4BD-074D-4BD9-A21A-A9A358DE2CFF}\" mediapath=\"\/Images\/ovoid-shape\/ovoid-2\" src=\"~\/media\/A322F4BD074D4BD9A21AA9A358DE2CFF.ashx\" alt=\"publications ovoid\" height=\"\" width=\"\" hspace=\"\" vspace=\"\" \/>\",\n  \"Summary\": \"Large-scale study from ICES shows HDL or \u201cgood\u201d cholesterol isn\u2019t a specific marker for heart health.\",\n  \"Location\": \"Toronto\",\n  \"In The News\": \"{34961AE7-FB24-4002-967E-C68B2A1505BE}|{7CD0A3C2-DB54-4698-9DC9-0370A275116B}\",\n  \"ICES Scientists\": \"{B3827152-93D1-4FB2-B106-590CB331A264}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"Related Products\": \"<h2>Journal article abstract<\/h2>rn<h3><a href=\"~\/link.aspx?_id=18A7129B5A034F268116D7AE77F41C81&amp;_z=z\">High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions <\/a><\/h3>rn<h2>Infographic<\/h2>rn<h3><a href=\"~\/link.aspx?_id=C7B5678E0603488DB4B175FC4453731F&amp;_z=z?year=2016&amp;page=1#cholesterolandhearthealth\">Risk of death from heart disease or cancer rises with either high or low HDL cholesterol<\/a><\/h3>\",\n  \"Posted Date\": \"20161031T135200\",\n  \"Publication Link\": \"<link text=\"Abstract\" linktype=\"internal\" url=\"\/ICES\/Home\/Publications\/Journal-Articles\/2016\/January\/High-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior\" title=\"Opens journal abstract\" querystring=\"\" target=\"\" id=\"{18A7129B-5A03-4F26-8116-D7AE77F41C81}\" \/>\",\n  \"Related Link\": \"<link text=\"ICES in the News | Washington Post\" linktype=\"external\" url=\"https:\/\/www.washingtonpost.com\/national\/health-science\/does-good-cholesterol-still-matter\/2017\/05\/26\/d6926a8a-0e69-11e7-9b0d-d27c98455440_story.html?utm_term=.141f7cdb92f0\" anchor=\"\" title=\"opens external link\" target=\"\" \/>\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Newsroom\/News-Releases\/2016\/Big-data-study-shows-good-cholesterol-not-the-best-marker-for-heart-health"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Big data study shows \u201cgood\u201d cholesterol not the best marker for 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