{"id":16174,"date":"2023-06-23T09:51:24","date_gmt":"2023-06-23T13:51:24","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=news_release&#038;p=16174"},"modified":"2023-07-10T15:22:25","modified_gmt":"2023-07-10T19:22:25","slug":"even-a-modest-reduction-in-kidney-function-increases-health-risks-in-young-adults","status":"publish","type":"news_release","link":"https:\/\/www.ices.on.ca\/fr\/news-releases\/even-a-modest-reduction-in-kidney-function-increases-health-risks-in-young-adults\/","title":{"rendered":"Even a modest reduction in kidney function increases health risks in young adults"},"content":{"rendered":"<p>A study of more than 8 million adults in Ontario, Canada suggests that even a modest loss of kidney function is associated with increased health risks. The study, published in <em>The BMJ<\/em>, could lead to better approaches to prevent chronic kidney disease and related conditions, particularly in younger adults.<\/p>\n<p>\u201cThe dogma is that healthy, young adults don\u2019t need to worry about kidney function unless it drops to around 50% of the normal level, but our research suggests that even a more modest 20-30% drop may have consequences and we may want to have earlier conversations about prevention and monitoring,\u201d said senior author Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/msood\">Manish Sood<\/a>, senior scientist, nephrologist and Jindal Research Chair for the Prevention of Kidney Disease at The Ottawa Hospital and professor at the University of Ottawa.<\/p>\n\n<div class=\"download-section alignwide infographic-download\" id=\"block_9963c5d267bf62a8382b4592001a9ed6\" data-style=\"deep-blue\">\n\t<div class=\"download-section-content\">\n\t\t\t\t<h2>\n\t\t\tInfographic\t\t<\/h2>\n\t\t\n\t\t\t<\/div>\n\t<div class=\"download-section-buttons\">\n\t\t\t\t\t\t<a class=\"download-section-buttons-primary\" href=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/06\/Hussain-Kidney-Function-scaled.jpg\" target=\"_blank\"\n\t\t\tdownload\t\t\taria-label=\"Download Infographic (opens in a new tab)\"\t\t>\n\t\t\tDownload Infographic\t\t\t<svg width=\"19\" height=\"19\" viewBox=\"0 0 19 19\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" role=\"presentation\">\n<path d=\"M2.78003 18.8301C2.14282 18.8301 1.59713 18.603 1.14297 18.1488C0.688813 17.6947 0.46212 17.1494 0.462893 16.5129V13.0372H2.78003V16.5129H16.6829V13.0372H19V16.5129C19 17.1502 18.7729 17.6958 18.3188 18.15C17.8646 18.6042 17.3193 18.8308 16.6829 18.8301H2.78003ZM9.73145 14.1958L3.9386 8.40295L5.5606 6.72303L8.57288 9.73531V0.292969H10.89V9.73531L13.9023 6.72303L15.5243 8.40295L9.73145 14.1958Z\" fill=\"#151D5D\"\/>\n<\/svg>\n\t\t<\/a>\n\t\t\n\t\t\t\t\t\t\t\t\t\t<button type=\"button\" class=\"download-section-buttons-secondary\" data-infographic-popup-open=\"block_9963c5d267bf62a8382b4592001a9ed6-infographic-popup\" aria-haspopup=\"dialog\">\n\t\t\t\tClick to View\t\t\t<\/button>\n\t\t\t\t\t\t<\/div>\n\n\t\t<div class=\"infographic-popup\" id=\"block_9963c5d267bf62a8382b4592001a9ed6-infographic-popup\" role=\"dialog\" aria-modal=\"true\" aria-label=\"Infographic\" hidden>\n\t\t<div class=\"infographic-popup-overlay\" data-infographic-popup-close><\/div>\n\t\t<div class=\"infographic-popup-container\">\n\t\t\t<button type=\"button\" class=\"infographic-popup-close\" data-infographic-popup-close aria-label=\"Close infographic\">&times;<\/button>\n\t\t\t<img decoding=\"async\" class=\"infographic-popup-image\" src=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/06\/Hussain-Kidney-Function-scaled.jpg\" alt=\"Infographic\">\n\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n<p>The research team examined ICES health record data from 2008 to 2021 for every Ontario adult aged 18-65 who had at least one blood test for kidney function, but no history of kidney disease. They found that 18% of those in the 18-39 age group had kidney function that was modestly below normal levels, but not low enough to be diagnosed with chronic kidney disease. Individuals in this \u201cgrey zone\u201d faced a modestly increased risk of kidney failure, death and cardiovascular events such as heart attack.<\/p>\n<p>For example, in young adults (age 18-39), a 20-30% loss in kidney function was associated with a 1.4-fold increase in death, 1.3-fold increase in a cardiac event and a 6-fold increase in the risk of kidney failure. However, the absolute risk of any of these events was still low at less than 2 per 1000.<\/p>\n<p>\u201cThankfully, the absolute risk for any one individual with kidney function in this grey zone is low, but when we look at the whole population, the impact could be quite significant,\u201d said co-senior author Dr. <a href=\"https:\/\/www.ohri.ca\/profile\/gknoll\">Greg Knoll<\/a>, senior scientist, nephrologist and Head of the Department of Medicine at The Ottawa Hospital and the University of Ottawa. \u201cWe need further research to confirm these findings and then see if we can reduce the risks through things like diet and other lifestyle changes.\u201d<\/p>\n<p>While the test for kidney function (blood creatine) is relatively inexpensive and readily available, the researchers are not suggesting routine testing for all individuals at this time. However, if an individual has had a kidney test that shows a modest reduction in function, it can be a catalyst for a conversation with a healthcare provider. All individuals can also reduce their risk of kidney disease by eating a healthy diet with lower salt, exercising regularly and limiting alcohol intake.<\/p>\n<p>Dr. Sood and his colleagues previously developed the <a href=\"https:\/\/www.projectbiglife.ca\/ckd\/landing-page\">Project BigLife Chronic Kidney Disease calculator<\/a> to help individuals calculate their kidney disease risk and see the impact of lifestyle changes. The calculator will continue to be refined as new research arises. &nbsp;<\/p>\n<p><strong>Media contact:<\/strong> Jenn Ganton, <a href=\"mailto:jganton@ohri.ca\">jganton@ohri.ca<\/a>, 613-614-5253<\/p>\n<p><strong>The Ottawa Hospital (TOH)<\/strong> is one of Canada\u2019s top learning and research hospitals where we are guided by our vision to provide the world-class and compassionate care we would all want for our loved ones. Our multi-campus hospital, affiliated with the University of Ottawa, is home to the Regional Trauma Centre and Cancer Centre, and to discoveries that are adopted globally. Backed by generous support from the community, we are focused on reshaping the future of healthcare to improve the health of our diverse population of patients from Eastern Ontario, Western Quebec, and Nunavut. For more information about research at The Ottawa Hospital, visit <a href=\"http:\/\/www.ohri.ca\">www.ohri.ca<\/a>. &nbsp;&nbsp;&nbsp;<\/p>\n<p><strong>ICES <\/strong>is an independent, non-profit research institute that uses population-based health information to produce knowledge on a broad range of healthcare issues. Our unbiased evidence provides measures of health system performance, a clearer understanding of the shifting healthcare needs of Ontarians, and a stimulus for discussion of practical solutions to optimize scarce resources. ICES knowledge is highly regarded in Canada and abroad and is widely used by government, hospitals, planners, and practitioners to make decisions about care delivery and to develop policy. For the latest ICES news, follow us on Twitter: @ICESOntario<\/p>\n<p>The <strong>University of Ottawa<\/strong> is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada\u2019s top 10 research universities\u2014our professors and researchers explore new approaches to today\u2019s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. <a href=\"http:\/\/www.uottawa.ca\">www.uottawa.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study of more than 8 million adults in Ontario, Canada suggests that even a modest loss of kidney function is associated with increased health risks. The study, published in The BMJ, could lead to better approaches to prevent chronic kidney disease and related conditions, particularly in younger adults. \u201cThe dogma is that healthy, young [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,49],"class_list":["post-16174","news_release","type-news_release","status-publish","hentry","topic-children-and-young-people","topic-kidney-disease"],"acf":{"infographic":[16172],"journal_article":[16155],"research_report":"","atlas":"","research_program":[6743],"site":[6734],"ices_scientist":[1107,1144],"announce_or_event":"","video":"","iitn_type":"Article","iitn_title":"Many young Canadians in the 'grey zone' when it comes to kidney function. Here's what that means for their health","iitn_short_title":"","iitn_source_link_url":"https:\/\/www.ctvnews.ca\/health\/many-young-canadians-in-the-grey-zone-when-it-comes-to-kidney-function-here-s-what-that-means-for-their-health-1.6451855","iitn_source_link_text":"","sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Even a modest reduction in kidney function increases health risks in young adults<\/title>\n<meta name=\"description\" content=\"A study of more than 8 million adults in Ontario, Canada suggests that even a modest loss of kidney function is associated with increased health risks.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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