{"id":6671,"date":"2016-04-20T00:00:00","date_gmt":"2016-04-20T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\/"},"modified":"2023-06-14T20:01:05","modified_gmt":"2023-06-15T00:01:05","slug":"comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\/","title":{"rendered":"Comparative effectiveness of generic atorvastatin and Lipitor\u00ae in patients hospitalized with an acute coronary syndrome"},"content":{"rendered":"<p><strong>Background <\/strong>&#x2014; Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern regarding their clinical effectiveness and safety. Lipitor<sup>&#xae;<\/sup>, available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effectiveness of generic atorvastatin products and Lipitor<sup>&#xae;<\/sup>.<\/p>\n<p><span class=\"bold\">Methods and Results<\/span> &#x2014; We conducted a population-based cohort study, using propensity score matching to minimize potential confounding of patients age 65 years, discharged alive after acute coronary syndrome (ACS) hospitalization between 2008 and 2012 in Ontario, Canada, who were prescribed Lipitor<sup>&#xae;<\/sup> or generic atorvastatin within 7 days of discharge. The primary outcome was 1-year death\/recurrent ACS hospitalization. Secondary outcomes included hospitalization for heart failure, stroke, new-onset diabetes, rhabdomyolysis, and renal failure. In the 7863 propensity-matched pairs (15 726 patients), mean age was 76.9 years, 56.3% were male, 87.6% had myocardial infarction, and all patients had complete follow-up. At 1 year, 17.7% of those prescribed generic atorvastatin and 17.7% of those prescribed Lipitor<sup>&#xae;<\/sup> experienced death or recurrent ACS (hazard ratio, 1.00; 95% CI, 0.93-1.08; P=0.94). No significant differences in rates of secondary outcomes between groups were observed. Prespecified subgroup analyses by age, sex, diabetes, atorvastatin dose, or admission diagnosis found no outcome difference between groups.<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor<sup>&#xae;<\/sup> at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and healthcare plans without diminishing population clinical effectiveness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern regarding their clinical effectiveness and safety. Lipitor&#xae;, available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effectiveness of generic atorvastatin products and Lipitor&#xae;. Methods and Results &#x2014; We conducted a population-based [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,56],"migration-helper-qa-sample-set":[],"class_list":["post-6671","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Jackevicius CA, Tu JV, Krumholz HM; Austin, PC, Ross JS, Stukel TA, Koh M, Chong A, Ko DT. <em>J Am Heart Assoc<\/em>. 2016; 5:e003350.","source_url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4859299\/","ices_scientist":[1281,1385,1372,1146,1140],"site":[6733],"research_program":[6742,6740],"news_release":[7647],"journal_article":[],"atlas":[],"research_report":[],"infographic":[9300],"video":[],"downloads":null,"links":null,"sitecore_item_id":"D6067986-598B-4550-9FF7-C2DDDE63EA80","sitecore_item_name":"Comparative-effectiveness-of-generic-atorvastatin-and-Lipitor-in-patients-with-ACS","sitecore_field_values":"{\n  \"__Valid from\": \"20170811T143026\",\n  \"Title\": \"Comparative effectiveness of generic atorvastatin and Lipitor\u00ae in patients hospitalized with an acute coronary syndrome\",\n  \"Short title\": \"Comparative effectiveness of generic\",\n  \"Summary\": \"This paper's findings support the use of generic atorvastatin in ACS which could lead to substantial cost saving without diminishing population clinical effectiveness.\",\n  \"Citation\": \"<p>Jackevicius CA, Tu JV, Krumholz HM; Austin, PC, Ross JS, Stukel TA, Koh M, Chong A, Ko DT. <em>J Am Heart Assoc<\/em>. 2016; 5:e003350. <\/p>\",\n  \"Abstract\": \"<p><strong>Background <\/strong>&mdash; Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern regarding their clinical effectiveness and safety. Lipitor<sup>&reg;<\/sup>, available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effectiveness of generic atorvastatin products and Lipitor<sup>&reg;<\/sup>.<\/p>n<p><span class=\"bold\">Methods and Results<\/span> &mdash; We conducted a population-based cohort study, using propensity score matching to minimize potential confounding of patients age 65 years, discharged alive after acute coronary syndrome (ACS) hospitalization between 2008 and 2012 in Ontario, Canada, who were prescribed Lipitor<sup>&reg;<\/sup> or generic atorvastatin within 7 days of discharge. The primary outcome was 1-year death\/recurrent ACS hospitalization. Secondary outcomes included hospitalization for heart failure, stroke, new-onset diabetes, rhabdomyolysis, and renal failure. In the 7863 propensity-matched pairs (15 726 patients), mean age was 76.9 years, 56.3% were male, 87.6% had myocardial infarction, and all patients had complete follow-up. At 1 year, 17.7% of those prescribed generic atorvastatin and 17.7% of those prescribed Lipitor<sup>&reg;<\/sup> experienced death or recurrent ACS (hazard ratio, 1.00; 95% CI, 0.93-1.08; P=0.94). No significant differences in rates of secondary outcomes between groups were observed. Prespecified subgroup analyses by age, sex, diabetes, atorvastatin dose, or admission diagnosis found no outcome difference between groups.<\/p>n<p><strong>Conclusions<\/strong> &mdash; Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor<sup>&reg;<\/sup> at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and healthcare plans without diminishing population clinical effectiveness.<\/p>n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4859299\/\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{5718D5DE-813C-4BEF-B244-C1252842E4D5}|{119824F7-24C7-4BEC-A5CC-4699A1DB30E1}|{53FC76BF-785B-4A1C-805E-1E03634BE9CF}\",\n  \"Related Products\": \"<h2>NEWS RELEASE<\/h2>rn<h3><a href=\"~\/link.aspx?_id=64E321CCD70B44858915BE8ADD6E9A3A&amp;_z=z\">Statins shown to be safe in generic form for high-risk coronary patients<\/a><\/h3>rn<h2>Infographic<\/h2>rn<h3><a href=\"~\/link.aspx?_id=C7B5678E0603488DB4B175FC4453731F&amp;_z=z?year=2016&amp;page=1#statins\">Statins shown to be safe and effective in generic form for acute coronary syndrome (ACS) patients<\/a><\/h3>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}|{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{BA86E62A-3468-443D-939F-34A9EFA7B7AA}|{956599EC-5699-41D3-9375-E0B6C25B12D5}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{A0978F87-1C10-4E62-A833-89616146CA59}|{B3827152-93D1-4FB2-B106-590CB331A264}|{5347DD83-0742-46B5-B0AC-4EF2A329F89E}\",\n  \"Posted Date\": \"20160420T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2016\/January\/Comparative-effectiveness-of-generic-atorvastatin-and-Lipitor-in-patients-with-ACS"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Comparative effectiveness of generic atorvastatin and Lipitor\u00ae in patients hospitalized with an acute coronary syndrome<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Comparative effectiveness of generic atorvastatin and Lipitor\u00ae in patients hospitalized with an acute coronary syndrome\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-15T00:01:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/comparative-effectiveness-of-generic-atorvastatin-and-lipitor-in-patients-hospitalized-with-an-acute-coronary-syndrome\\\/\",\"name\":\"ICES | Comparative effectiveness of generic atorvastatin and Lipitor\u00ae in patients hospitalized with an acute coronary syndrome\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-04-20T04:00:00+00:00\",\"dateModified\":\"2023-06-15T00:01:05+00:00\",\"description\":\"Background &#x2014; 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