{"id":6485,"date":"2016-10-31T00:00:00","date_gmt":"2016-10-31T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/high-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior-cardiovascular-conditions-the-canheart-study\/"},"modified":"2023-06-14T20:05:42","modified_gmt":"2023-06-15T00:05:42","slug":"high-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior-cardiovascular-conditions-the-canheart-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/high-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior-cardiovascular-conditions-the-canheart-study\/","title":{"rendered":"High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions: the CANHEART Study"},"content":{"rendered":"

Background <\/strong>— The prognostic importance of high-density lipoprotein (HDL) cholesterol as a specific risk factor for cardiovascular disease has been challenged by recent clinical trials and genetic studies. <\/p>\n

Objective<\/strong> — To reappraise the association of HDL cholesterol level with cardiovascular and noncardiovascular mortality utilizing a “big data” approach. <\/p>\n

Methods <\/strong>— An observation cohort study was conducted using the Cardiovascular Health in Ambulatory Care Research Team (CANHEART) dataset, which was created by linking together 17 different individual-level data sources. Individuals between 40 to 105 years old on January 1st<\/sup> 2008, living in Ontario, Canada, without prior cardiovascular conditions or severe comorbidities, and had an outpatient fasting cholesterol measurement in the year prior to the inception date were included. The primary outcome was cause-specific mortality (cardiovascular, cancer, and other). <\/p>\n

Results<\/strong> — A total of 631,762 individuals were included. The mean age of our cohort was 57.2 years, 55.4% were women, and mean HDL cholesterol level was 55.2 mg\/dL. There were 17,952 deaths during a mean follow-up period of 4.9 ± 0.4 years. The overall all-cause mortality rate was 8.1 per 1000 person-years for men and 6.6 per 1000 person-years for women. Individuals with lower HDL cholesterol levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors, and medical comorbidities. Lower HDL cholesterol levels were independently associated with higher risk of cardiovascular, cancer, and other mortality compared with individual in the reference ranges of HDL cholesterol levels. In addition, individuals with higher HDL levels (> 70 mg\/dL in men, > 90 mg\/dL in women) also had increased hazard of non-cardiovascular mortality. <\/p>\n

Conclusions<\/strong> — Complex associations exist between HDL cholesterol levels and socio-demographic, lifestyle, comorbidity factors, and mortality. HDL cholesterol level is unlikely to represent a cardiovascular specific risk-factor given similarities in its associations with non-cardiovascular outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background — The prognostic importance of high-density lipoprotein (HDL) cholesterol as a specific risk factor for cardiovascular disease has been challenged by recent clinical trials and genetic studies. Objective — To reappraise the association of HDL cholesterol level with cardiovascular and noncardiovascular mortality utilizing a “big data” approach. Methods — An observation cohort study was […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,59,35],"migration-helper-qa-sample-set":[],"class_list":["post-6485","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-data-science","topic-public-health"],"acf":{"citation":"Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, Tu JV. J Am Coll Cardiol<\/em>. 2016; 68(19):2073-83. Epub 2016 Oct 31.","source_url":"","ices_scientist":[1146,1381,1385,1175,1272,1281,1290,1133,1140],"site":[6733,6735,6734],"research_program":[6742,6746],"news_release":[7672],"journal_article":[],"atlas":[],"research_report":[],"infographic":[9306],"video":[],"downloads":null,"links":null,"sitecore_item_id":"18A7129B-5A03-4F26-8116-D7AE77F41C81","sitecore_item_name":"High-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior","sitecore_field_values":"{\n \"__Never publish\": null,\n \"__Valid from\": \"20161031T144600\",\n \"Title\": \"High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions: the CANHEART Study\",\n \"Summary\": \"The researchers found that HDL is not an independent heart disease risk factor.\",\n \"Citation\": \"

Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, Tu JV. J Am Coll Cardiol<\/em>. 2016; 68(19):2073-83. Epub 2016 Oct 31.<\/p>\",\n \"Abstract\": \"

Background <\/strong>— The prognostic importance of high-density lipoprotein (HDL) cholesterol as a specific risk factor for cardiovascular disease has been challenged by recent clinical trials and genetic studies. <\/p>rn

Objective<\/strong> — To reappraise the association of HDL cholesterol level with cardiovascular and noncardiovascular mortality utilizing a “big data” approach. <\/p>rn

Methods <\/strong>— An observation cohort study was conducted using the Cardiovascular Health in Ambulatory Care Research Team (CANHEART) dataset, which was created by linking together 17 different individual-level data sources. Individuals between 40 to 105 years old on January 1st<\/sup> 2008, living in Ontario, Canada, without prior cardiovascular conditions or severe comorbidities, and had an outpatient fasting cholesterol measurement in the year prior to the inception date were included. The primary outcome was cause-specific mortality (cardiovascular, cancer, and other). <\/p>rn

Results<\/strong> — A total of 631,762 individuals were included. The mean age of our cohort was 57.2 years, 55.4% were women, and mean HDL cholesterol level was 55.2 mg\/dL. There were 17,952 deaths during a mean follow-up period of 4.9 ± 0.4 years. The overall all-cause mortality rate was 8.1 per 1000 person-years for men and 6.6 per 1000 person-years for women. Individuals with lower HDL cholesterol levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors, and medical comorbidities. Lower HDL cholesterol levels were independently associated with higher risk of cardiovascular, cancer, and other mortality compared with individual in the reference ranges of HDL cholesterol levels. In addition, individuals with higher HDL levels (> 70 mg\/dL in men, > 90 mg\/dL in women) also had increased hazard of non-cardiovascular mortality. <\/p>rn

Conclusions<\/strong> — Complex associations exist between HDL cholesterol levels and socio-demographic, lifestyle, comorbidity factors, and mortality. HDL cholesterol level is unlikely to represent a cardiovascular specific risk-factor given similarities in its associations with non-cardiovascular outcomes.<\/p>\",\n \"Keywords\": \"{92E2791D-5DAB-4244-8A85-434D524D9A12}|{D130ADD9-0370-4BF6-9BBB-7379AF0263F0}|{C4D3C1D1-3961-46CB-8A65-47C6A8EC2AB9}\",\n \"Related Products\": \"

News release<\/h2>n

Big data study shows \"good' cholesterol not the best marker for heart health<\/a><\/h3>n

Infographic<\/h2>n

Risk of death from heart disease or cancer rises with either high or low HDL cholesterol<\/a><\/h3>n

ICES in the news<\/h2>n

Raising ‘good’ cholesterol doesn’t protect against heart disease after all, study finds <\/a><\/h3>n

Does ‘good’ cholesterol still matter?<\/a><\/h3>\",\n \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}|{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}|{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}|{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}\",\n \"ICES Scientists\": \"{B3827152-93D1-4FB2-B106-590CB331A264}|{5178A761-5208-4E70-ABF8-146FCEB83294}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{98B8617F-C6B9-4032-9C0D-7053D3651ABA}|{81017B85-00A9-49CC-8A47-390139E246AF}|{BA86E62A-3468-443D-939F-34A9EFA7B7AA}|{CEEE13AD-C7DE-455F-ACF8-AAD7D27BB178}|{8C2597F4-2B41-4E87-9F28-6887C689651B}|{956599EC-5699-41D3-9375-E0B6C25B12D5}|{5347DD83-0742-46B5-B0AC-4EF2A329F89E}\",\n \"Posted Date\": \"20161031T000000\",\n \"Show on Publications Landing Page\": \"1\",\n \"In The News\": null\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2016\/January\/High-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior"},"yoast_head":"\nICES | High-density lipoprotein cholesterol and cause-specific mortality in individuals without prior cardiovascular conditions: the CANHEART Study<\/title>\n<meta name=\"description\" content=\"Background — The prognostic importance of high-density lipoprotein (HDL) cholesterol as a specific risk factor for cardiovascular disease has been\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/high-density-lipoprotein-cholesterol-and-cause-specific-mortality-in-individuals-without-prior-cardiovascular-conditions-the-canheart-study\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" 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