{"id":6471,"date":"2016-07-11T00:00:00","date_gmt":"2016-07-11T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/association-of-blood-donor-age-and-sex-with-recipient-survival-after-red-blood-cell-transfusion\/"},"modified":"2023-06-14T19:49:00","modified_gmt":"2023-06-14T23:49:00","slug":"association-of-blood-donor-age-and-sex-with-recipient-survival-after-red-blood-cell-transfusion","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-blood-donor-age-and-sex-with-recipient-survival-after-red-blood-cell-transfusion\/","title":{"rendered":"Association of blood donor age and sex with recipient survival after red blood cell transfusion"},"content":{"rendered":"<p><strong>Importance<\/strong> &#x2014; While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine.<\/p>\n<p><strong>Objective<\/strong> &#x2014; To analyze the association of RBC donor age and sex with the survival of transfusion recipients.<\/p>\n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &#x2014; We established a longitudinal cohort by linking data from a blood collection agency with clinical and administrative data at 4 academic hospitals.<\/p>\n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &#x2014; Cox proportional hazards regression modelswere fitted to evaluate the risk of donor age and sex on transfusion recipient survival.<\/p>\n<p><strong>Results<\/strong> &#x2014; Between October 25, 2006, and December 31, 2013, a total of 30 503 RBC transfusion recipients received 187 960 RBC transfusions from 80 755 unique blood donors. For recipients receiving an RBC unit from younger donors, the risk of death was increased compared with recipients receiving an RBC unit from a donor 40 to 49.9 years old (adjusted hazard ratio, 1.08; 95%CI, 1.06-1.10; P &lt; .001 for donor age range 17-19.9 years and 1.06; 95% CI, 1.04-1.09; P &lt; .001 for donor age range 20-29.9 years). Receiving an RBC transfusion from a female donor was associated with an 8%statistically significant increased risk of death compared with receiving an RBC transfusion from a male donor (adjusted hazard ratio, 1.08; 95%CI, 1.06-1.09; P &lt; .001).<\/p>\n<p><span class=\"bold\">Conclusions and Relevance<\/span> &#x2014; Red blood cell transfusions from younger donors and from female donors were statistically significantly associated with increased mortality. These findings suggest that donor characteristics may affect RBC transfusion outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance &#x2014; While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine. Objective &#x2014; To analyze the association of RBC donor age and sex [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[62,54],"migration-helper-qa-sample-set":[],"class_list":["post-6471","journal_article","type-journal_article","status-publish","hentry","topic-health-services-research","topic-organ-transplantation-and-donation"],"acf":{"citation":"Chass&#xe9; M, Tinmouth A, English SW, Acker JP, Wilson K, Knoll G, Shehata N, van Walraven C, Forster AJ, Ramsay T, McIntyre LA, Fergusson DA. <em>JAMA Intern Med. <\/em>2016; 176(9):1307-14. Epub 2016 Jul 11.","source_url":"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2532790","ices_scientist":[1119],"site":[6734],"research_program":[],"news_release":[7631],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"9972BDEE-8687-4B18-A5D9-8CF6309A4738","sitecore_item_name":"Association-of-blood-donor-age-and-sex-with-recipient-survival-after-red-blood-cell-transfusion","sitecore_field_values":"{\n  \"Title\": \"Association of blood donor age and sex with recipient survival after red blood cell transfusion\",\n  \"Short title\": \"Association of blood donor age and sex\",\n  \"Summary\": \"This study found that red blood cell transfusions from younger donors and from female donors were statistically significantly associated with increased mortality.\",\n  \"Citation\": \"<p>Chass&eacute; M, Tinmouth A, English SW, Acker JP, Wilson K, Knoll G, Shehata N, van Walraven C, Forster AJ, Ramsay T, McIntyre LA, Fergusson DA. <em>JAMA Intern Med. <\/em>2016; 176(9):1307-14. Epub 2016 Jul 11.<\/p>\",\n  \"Abstract\": \"<p><strong>Importance<\/strong> &mdash; While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine.<\/p>n<p><strong>Objective<\/strong> &mdash; To analyze the association of RBC donor age and sex with the survival of transfusion recipients.<\/p>n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &mdash; We established a longitudinal cohort by linking data from a blood collection agency with clinical and administrative data at 4 academic hospitals.<\/p>n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &mdash; Cox proportional hazards regression modelswere fitted to evaluate the risk of donor age and sex on transfusion recipient survival.<\/p>n<p><strong>Results<\/strong> &mdash; Between October 25, 2006, and December 31, 2013, a total of 30 503 RBC transfusion recipients received 187 960 RBC transfusions from 80 755 unique blood donors. For recipients receiving an RBC unit from younger donors, the risk of death was increased compared with recipients receiving an RBC unit from a donor 40 to 49.9 years old (adjusted hazard ratio, 1.08; 95%CI, 1.06-1.10; P &lt; .001 for donor age range 17-19.9 years and 1.06; 95% CI, 1.04-1.09; P &lt; .001 for donor age range 20-29.9 years). Receiving an RBC transfusion from a female donor was associated with an 8%statistically significant increased risk of death compared with receiving an RBC transfusion from a male donor (adjusted hazard ratio, 1.08; 95%CI, 1.06-1.09; P &lt; .001).<\/p>n<p><span class=\"bold\">Conclusions and Relevance<\/span> &mdash; Red blood cell transfusions from younger donors and from female donors were statistically significantly associated with increased mortality. These findings suggest that donor characteristics may affect RBC transfusion outcomes.<\/p>n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2532790\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{A39C5396-16B7-4369-B0F9-31F6E91E46FC}|{A52B40A3-3A32-4229-A150-B1F49A292A71}|{EDACCF0C-A0D0-4496-9216-D3055A23BC38}\",\n  \"Related Products\": \"<h2>News Release<\/h2>rn<h3><a href=\"~\/link.aspx?_id=8C6168490BE646D9B635269A9890CF86&amp;_z=z\">Researchers find unexpected association between younger donor age, female sex and transfusion outcomes<\/a><\/h3>rn<h2>ICES IN THE NEWS<\/h2>rn<h3><a href=\"http:\/\/www.dailymail.co.uk\/health\/article-3685308\/Patients-receive-blood-transfusions-young-female-donors-likely-die.html\" title=\"Opens in new window\" target=\"_blank\">Patients who receive blood transfusions from young, female donors 'are more likely to die'<\/a><\/h3>\",\n  \"Research Programs\": \"{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}\",\n  \"ICES Locations\": \"{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}\",\n  \"ICES Scientists\": \"{27680717-A18A-415F-82BB-D193C9AABE27}|{372EE381-9B1A-49F5-AC1B-0D8675558A8D}\",\n  \"Posted Date\": \"20160711T095100\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2016\/January\/Association-of-blood-donor-age-and-sex-with-recipient-survival-after-red-blood-cell-transfusion"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Association of blood donor age and sex with recipient survival after red blood cell transfusion<\/title>\n<meta name=\"description\" content=\"Importance &#x2014; 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