{"id":6462,"date":"2016-05-11T00:00:00","date_gmt":"2016-05-11T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/population-level-impact-of-ontarios-infant-rotavirus-immunization-program-evidence-of-direct-and-indirect-effects\/"},"modified":"2023-06-14T19:48:34","modified_gmt":"2023-06-14T23:48:34","slug":"population-level-impact-of-ontarios-infant-rotavirus-immunization-program-evidence-of-direct-and-indirect-effects","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/population-level-impact-of-ontarios-infant-rotavirus-immunization-program-evidence-of-direct-and-indirect-effects\/","title":{"rendered":"Population-level impact of Ontario\u2019s infant rotavirus immunization program: evidence of direct and indirect effects"},"content":{"rendered":"

Objective<\/strong> — To evaluate the direct and indirect population impact of rotavirus (RV) immunization on hospitalizations and emergency department (ED) visits for acute gastroenteritis (AGE) in Ontario before and after the publicly-funded RV immunization program.<\/p>\n

Methods<\/strong> — Administrative data was used to identify ED visits and hospitalizations for all Ontarians using ICD-10 codes. We used two outcome definitions: RV-specific AGE (RV-AGE) and codes representing RV-, other viral and cause unspecified AGE (“overall AGE”). The pre-program and public program periods were August 1, 2005 to July 31, 2011; and August 1, 2011 to March 31, 2013, respectively. A negative binominal regression model that included the effect of time was used to calculate rates and rate ratios (RRs) and 95% confidence intervals (CIs) for RV-AGE and overall AGE between periods, after adjusting for age, seasonality and secular trends. Analyses were conducted for all ages combined and age stratified. <\/p>\n

Results<\/strong> — Relative to the pre-program period, the adjusted RRs for RV-AGE and overall AGE hospitalizations in the public program period were 0.29 (95%CI: 0.22-0.39) and 0.68 (95%CI: 0.62-0.75), respectively. Significant reductions in RV-AGE hospitalizations were noted overall and for the following age bands: < 12 months, 12-23 months, 24-35 months, 3-4 years, and 5-19 years. Significant declines in overall AGE hospitalizations were observed across all age bands, including older adults >= 65 years (RR 0.80, 95% CI: 0.72-0.90). The program was associated with adjusted RRs of 0.32 (95% CI: 0.20-0.52) for RV-AGE ED visits and 0.90 (95% CI: 0.85-0.96) for overall AGE ED visits. <\/p>\n

Conclusions<\/strong> — This large, population-based study provides evidence of the impact of RV vaccine in preventing hospitalizations and ED visits for RV-AGE and overall AGE, including herd effects.<\/p>\n","protected":false},"excerpt":{"rendered":"

Objective — To evaluate the direct and indirect population impact of rotavirus (RV) immunization on hospitalizations and emergency department (ED) visits for acute gastroenteritis (AGE) in Ontario before and after the publicly-funded RV immunization program. Methods — Administrative data was used to identify ED visits and hospitalizations for all Ontarians using ICD-10 codes. We used […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[48,39,27,35],"migration-helper-qa-sample-set":[],"class_list":["post-6462","journal_article","type-journal_article","status-publish","hentry","topic-gastroenterology","topic-infectious-diseases","topic-pediatrics","topic-public-health"],"acf":{"citation":"Wilson SE, Rosella LC, Wang J, Le Saux N, Crowcroft NS, Harris T, Bolotin S, Deeks SL. PLoS One<\/em>. 2016; 11(5):e0154340. Epub 2016 May 11.","source_url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4864308\/","ices_scientist":[1339,1126],"site":[6735],"research_program":[],"news_release":[7656],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"957FAC9C-D905-42CC-BD34-8B3C181D8FA4","sitecore_item_name":"Population-level-impact-of-Ontario-infant-rotavirus-immunization-program","sitecore_field_values":"{\n \"__Valid from\": \"20170811T145618\",\n \"Title\": \"Population-level impact of Ontario\u2019s infant rotavirus immunization program: evidence of direct and indirect effects\",\n \"Short title\": \"Population-level impact of Ontario\u2019s\",\n \"Summary\": \"This large, population-based study provides evidence of the impact of RV vaccine in preventing hospitalizations and ED visits for RV-AGE and overall AGE, including herd effects.\",\n \"Citation\": \"

Wilson SE, Rosella LC, Wang J, Le Saux N, Crowcroft NS, Harris T, Bolotin S, Deeks SL. PLoS One<\/em>. 2016; 11(5):e0154340. Epub 2016 May 11.<\/p>\",\n \"Abstract\": \"

Objective<\/strong> — To evaluate the direct and indirect population impact of rotavirus (RV) immunization on hospitalizations and emergency department (ED) visits for acute gastroenteritis (AGE) in Ontario before and after the publicly-funded RV immunization program.<\/p>n

Methods<\/strong> — Administrative data was used to identify ED visits and hospitalizations for all Ontarians using ICD-10 codes. We used two outcome definitions: RV-specific AGE (RV-AGE) and codes representing RV-, other viral and cause unspecified AGE (“overall AGE”). The pre-program and public program periods were August 1, 2005 to July 31, 2011; and August 1, 2011 to March 31, 2013, respectively. A negative binominal regression model that included the effect of time was used to calculate rates and rate ratios (RRs) and 95% confidence intervals (CIs) for RV-AGE and overall AGE between periods, after adjusting for age, seasonality and secular trends. Analyses were conducted for all ages combined and age stratified. <\/p>n

Results<\/strong> — Relative to the pre-program period, the adjusted RRs for RV-AGE and overall AGE hospitalizations in the public program period were 0.29 (95%CI: 0.22-0.39) and 0.68 (95%CI: 0.62-0.75), respectively. Significant reductions in RV-AGE hospitalizations were noted overall and for the following age bands: < 12 months, 12-23 months, 24-35 months, 3-4 years, and 5-19 years. Significant declines in overall AGE hospitalizations were observed across all age bands, including older adults >= 65 years (RR 0.80, 95% CI: 0.72-0.90). The program was associated with adjusted RRs of 0.32 (95% CI: 0.20-0.52) for RV-AGE ED visits and 0.90 (95% CI: 0.85-0.96) for overall AGE ED visits. <\/p>n

Conclusions<\/strong> — This large, population-based study provides evidence of the impact of RV vaccine in preventing hospitalizations and ED visits for RV-AGE and overall AGE, including herd effects.<\/p>n

View full text<\/a><\/p>\",\n \"Keywords\": \"{65D0A3C1-88FE-4F8F-B010-9B643FDA1A82}|{3520E276-FC47-4BE8-BC0D-5FD075E6DBEF}|{128D8B1B-1143-4080-9185-2C8A3C4BDC30}|{74DB518C-6065-4C1C-8C36-2B911B9CE7D0}\",\n \"Related Products\": \"

NEWS RELEASE<\/h2>rn

Ontario rotavirus hospitalizations drop 71% after launch of infant vaccine program<\/a><\/h3>rn

ICES IN THE NEWS<\/h2>rn

Infant rotavirus vaccination program reduces hospitalizations by 70 per cent<\/a><\/h3>\",\n \"Research Programs\": \"{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}\",\n \"ICES Locations\": \"{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n \"ICES Scientists\": \"{430B2731-D3D6-4D57-9AF4-AA7626CF61B0}|{5EF9EEB7-BC22-4C59-A015-0CAC2A1B54EA}|{7325515F-322B-448F-B845-746353A3DD14}\",\n \"Posted Date\": \"20160511T000000\",\n \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2016\/January\/Population-level-impact-of-Ontario-infant-rotavirus-immunization-program"},"yoast_head":"\nICES | Population-level impact of Ontario\u2019s infant rotavirus immunization program: evidence of direct and indirect effects<\/title>\n<meta name=\"description\" content=\"Objective — To evaluate the direct and indirect population impact of rotavirus (RV) immunization on hospitalizations and emergency department (ED)\" \/>\n<meta name=\"robots\" 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