{"id":6415,"date":"2016-01-07T00:00:00","date_gmt":"2016-01-07T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/cancer-mortality-among-recipients-of-solid-organ-transplantation-in-ontario-canada\/"},"modified":"2023-06-14T19:31:40","modified_gmt":"2023-06-14T23:31:40","slug":"cancer-mortality-among-recipients-of-solid-organ-transplantation-in-ontario-canada","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/cancer-mortality-among-recipients-of-solid-organ-transplantation-in-ontario-canada\/","title":{"rendered":"Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada"},"content":{"rendered":"

Importance<\/strong> — Solid organ transplantation recipients (SOTR) are at greater risk of developing some cancers than the general population, however because they are also at increased risk of mortality from non-cancer causes, the impact of transplantation on cancer mortality is unclear. <\/p>\n

Objective <\/strong>— To describe cancer mortality in solid organ transplantation recipients and to assess whether solid organ transplantation recipients are at increased risk of cancer mortality compared to the general population.<\/p>\n

Design<\/strong> — Population-based cohort study of patients who underwent solid organ transplantation between 1991 and 2010 with 85 557 person-years of follow up.<\/p>\n

Setting<\/strong> — Ontario, Canada.<\/p>\n

Participants<\/strong> — 11 061 solid organ transplantation recipients: 6 516 kidney, 2 606 liver, 929 heart, and 705 lung transplantations.<\/p>\n

Exposure<\/strong> — Solid organ transplantation was identified using the national transplant register and linked to the provincial cancer registry and administrative databases.<\/p>\n

Main Outcomes and Measures<\/span> — Cancer mortality for SOTR was compared to the general population using standardized mortality ratios (SMR). Mortality and cause of death were ascertained by record linkage between the Canadian Organ Transplant Register, the Ontario Cancer Registry, and the Office of the Registrar General of Ontario death database.<\/p>\n

Results<\/strong> — Out of 3 068 deaths, 603 (19.7%) were cancer-related. Cancer mortality in solid organ transplantation recipients was significantly elevated compared to the Ontario population (SMR 2.84, 95% CI: 2.61–3.07). The risk remained elevated when patients with pre-transplant malignancies (n=1,124) were excluded (SMR 1.93; 95% CI: 1.75–2.13). The increased risk was observed irrespective of transplanted organ and sex. The SMR for cancer death after solid organ transplantation recipients was higher in children and lower in patients >60 years, but remained elevated compared to the general population at all ages.<\/p>\n

Conclusion and Relevance<\/span> — Cancer death rate in solid organ transplantation recipients was increased compared to that expected in the general population; malignancy was in fact the second leading cause of death in these patients. Advances in prevention, clinical surveillance, and cancer treatment modalities for solid organ transplantation recipients are needed to reduce the burden of cancer mortality in this population.<\/p>\n","protected":false},"excerpt":{"rendered":"

Importance — Solid organ transplantation recipients (SOTR) are at greater risk of developing some cancers than the general population, however because they are also at increased risk of mortality from non-cancer causes, the impact of transplantation on cancer mortality is unclear. Objective — To describe cancer mortality in solid organ transplantation recipients and to assess […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,54],"migration-helper-qa-sample-set":[],"class_list":["post-6415","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-organ-transplantation-and-donation"],"acf":{"citation":"Acuna SA, Fernandes KA, Daly C, Hicks LK, Sutradhar R, Kim SJ, Baxter NN. JAMA Oncol<\/em>. 2016; 2(4):463-9. Epub 2016 Jan 7.","source_url":"","ices_scientist":[1177,1370,1153],"site":[6733,6739],"research_program":[6741,6743],"news_release":[7689],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"BBFB19CA-6882-4B87-AF86-3D536B9C5B45","sitecore_item_name":"Cancer-mortality-among-recipients-of-solid-organ-transplantation-in-Ontario","sitecore_field_values":"{\n \"Title\": \"Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada\",\n \"Summary\": \"The objective was to assess whether solid organ transplantation recipients are at increased risk of cancer mortality compared to the general population.\",\n \"Citation\": \"

Acuna SA, Fernandes KA, Daly C, Hicks LK, Sutradhar R, Kim SJ, Baxter NN. JAMA Oncol<\/em>. 2016; 2(4):463-9. Epub 2016 Jan 7.<\/p>\",\n \"Abstract\": \"

Importance<\/strong> — Solid organ transplantation recipients (SOTR) are at greater risk of developing some cancers than the general population, however because they are also at increased risk of mortality from non-cancer causes, the impact of transplantation on cancer mortality is unclear. <\/p>rn

Objective <\/strong>— To describe cancer mortality in solid organ transplantation recipients and to assess whether solid organ transplantation recipients are at increased risk of cancer mortality compared to the general population.<\/p>rn

Design<\/strong> — Population-based cohort study of patients who underwent solid organ transplantation between 1991 and 2010 with 85 557 person-years of follow up.<\/p>rn

Setting<\/strong> — Ontario, Canada.<\/p>rn

Participants<\/strong> — 11 061 solid organ transplantation recipients: 6 516 kidney, 2 606 liver, 929 heart, and 705 lung transplantations.<\/p>rn

Exposure<\/strong> — Solid organ transplantation was identified using the national transplant register and linked to the provincial cancer registry and administrative databases.<\/p>rn

Main Outcomes and Measures<\/span> — Cancer mortality for SOTR was compared to the general population using standardized mortality ratios (SMR). Mortality and cause of death were ascertained by record linkage between the Canadian Organ Transplant Register, the Ontario Cancer Registry, and the Office of the Registrar General of Ontario death database.<\/p>rn

Results<\/strong> — Out of 3 068 deaths, 603 (19.7%) were cancer-related. Cancer mortality in solid organ transplantation recipients was significantly elevated compared to the Ontario population (SMR 2.84, 95% CI: 2.61–3.07). The risk remained elevated when patients with pre-transplant malignancies (n=1,124) were excluded (SMR 1.93; 95% CI: 1.75–2.13). The increased risk was observed irrespective of transplanted organ and sex. The SMR for cancer death after solid organ transplantation recipients was higher in children and lower in patients >60 years, but remained elevated compared to the general population at all ages.<\/p>rn

Conclusion and Relevance<\/span> — Cancer death rate in solid organ transplantation recipients was increased compared to that expected in the general population; malignancy was in fact the second leading cause of death in these patients. Advances in prevention, clinical surveillance, and cancer treatment modalities for solid organ transplantation recipients are needed to reduce the burden of cancer mortality in this population.<\/p>\",\n \"Keywords\": \"{4F321D0E-F7F1-4C8D-B2FE-922AD8DE3C78}|{A52B40A3-3A32-4229-A150-B1F49A292A71}|{EDACCF0C-A0D0-4496-9216-D3055A23BC38}\",\n \"Related Products\": \"

NEWS RELEASE<\/h2>rn

Threefold risk of death from cancer after solid organ transplant, says new Ontario study <\/a><\/h3>rn

ICES IN THE NEWS<\/h2>rn

Organ transplant patients up to 3 times more likely to die from cancer: study<\/a><\/h3>\",\n \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}|{92CC48EB-79AA-49F6-8A80-16D185170261}\",\n \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n \"ICES Scientists\": \"{73B9FD95-5453-4FBA-B02E-CD2911B86ACD}|{56BF24FA-D81E-4114-BF1F-4715A424E26C}|{6B4960E0-E1DA-49EB-87C0-85D66231D0E0}\",\n \"Posted Date\": \"20160107T000000\",\n \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2016\/January\/Cancer-mortality-among-recipients-of-solid-organ-transplantation-in-Ontario"},"yoast_head":"\nICES | Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Importance — Solid organ transplantation recipients (SOTR) are at greater risk of developing some cancers than the general population, 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