{"id":5845,"date":"2019-01-21T00:00:00","date_gmt":"2019-01-21T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis-using-health-administrative-data\/"},"modified":"2023-06-14T19:35:30","modified_gmt":"2023-06-14T23:35:30","slug":"predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis-using-health-administrative-data","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis-using-health-administrative-data\/","title":{"rendered":"Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed clinical information relating to disease burden. We used Ontario health administrative data to develop predictive models of disease burden at diagnosis in ulcerative colitis (UC) patients for future use in population-based studies of incident UC cohorts.<\/p>\n<p><strong>Methods<\/strong> &#x2014; Through chart review, we characterized macroscopic colitis activity and extent at diagnosis in consecutive adult-onset UC patients diagnosed at The Ottawa Hospital between 2001 and 2012. We linked this cohort to Ontario health administrative data to test the capacity of administrative variables to discriminate different levels of disease activity, disease extent and the disease burden (a composite of disease extent and activity). We modelled outcomes as binary (using logistic regression) and ordinal (using proportional odds regression) variables and performed bootstrap validation of our final models.<\/p>\n<p><strong>Results<\/strong> &#x2014; We tested 20 administrative variables in 587 eligible patients. The logistic model of total disease burden (severe and extensive colitis vs. all other phenotypes) showed moderate discriminatory capacity (optimism-corrected c-statistic value 0.729). Individual models of disease extent and disease activity showed poorer discriminatory capacity (c-statistic value &lt; 0.7 for 3 of 4 models).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Ontario health administrative data may reasonably discriminate levels of total disease burden at diagnosis in adult-onset UC patients. Our models should be externally validated before their widespread application in future population-based studies of incident UC cohorts to adjust for the confounding effects of differences in disease burden.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed clinical information relating to disease burden. We used Ontario health administrative data to develop predictive models of disease burden at diagnosis in ulcerative [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-5845","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Murthy SK, Shukla T, Antonova L, Belair MA, Ramsay T, Gallinger Z, Nguyen GC, Benchimol EI. <em>BMC Gastroenterol<\/em>. 2019; 19:13. Epub 2019 Jan 21.","source_url":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-018-0924-6","ices_scientist":[1301,1174,1317],"site":[6734],"research_program":[6740],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"4DE5EFAD-F4A6-43C6-A5E0-4F106A81354E","sitecore_item_name":"Predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis","sitecore_field_values":"{\n  \"Title\": \"Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data\",\n  \"Short title\": \"Predictive models of disease burden at\",\n  \"Summary\": \"This study used health administrative data to develop predictive models of disease burden at diagnosis in ulcerative colitis patients for future use in population-based studies of incident UC cohorts.\",\n  \"Citation\": \"<p>Murthy SK, Shukla T, Antonova L, Belair MA, Ramsay T, Gallinger Z, Nguyen GC, Benchimol EI. <em>BMC Gastroenterol<\/em>. 2019; 19:13. Epub 2019 Jan 21.<\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed clinical information relating to disease burden. We used Ontario health administrative data to develop predictive models of disease burden at diagnosis in ulcerative colitis (UC) patients for future use in population-based studies of incident UC cohorts.<\/p>n<p><strong>Methods<\/strong> &mdash; Through chart review, we characterized macroscopic colitis activity and extent at diagnosis in consecutive adult-onset UC patients diagnosed at The Ottawa Hospital between 2001 and 2012. We linked this cohort to Ontario health administrative data to test the capacity of administrative variables to discriminate different levels of disease activity, disease extent and the disease burden (a composite of disease extent and activity). We modelled outcomes as binary (using logistic regression) and ordinal (using proportional odds regression) variables and performed bootstrap validation of our final models.<\/p>n<p><strong>Results<\/strong> &mdash; We tested 20 administrative variables in 587 eligible patients. The logistic model of total disease burden (severe and extensive colitis vs. all other phenotypes) showed moderate discriminatory capacity (optimism-corrected c-statistic value 0.729). Individual models of disease extent and disease activity showed poorer discriminatory capacity (c-statistic value &lt; 0.7 for 3 of 4 models).<\/p>n<p><strong>Conclusions<\/strong> &mdash; Ontario health administrative data may reasonably discriminate levels of total disease burden at diagnosis in adult-onset UC patients. Our models should be externally validated before their widespread application in future population-based studies of incident UC cohorts to adjust for the confounding effects of differences in disease burden.<\/p>n<p><a href=\"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-018-0924-6\" title=\"View full text\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"ICES Locations\": \"{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}\",\n  \"ICES Scientists\": \"{B745F78B-F800-48D1-96E0-706773D0C8C8}|{85C78233-ED47-42C4-BF65-524CF15A8219}|{66C7A76E-67E6-4938-8E98-62B9230A9032}\",\n  \"Posted Date\": \"20190121T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2019\/January\/Predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/predictive-models-of-disease-burden-at-diagnosis-in-persons-with-adult-onset-ulcerative-colitis-using-health-administrative-data\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; Health administrative data is increasingly used to conduct population-based health services research. 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