Sarcoidosis related mortality appears to be rising in North America, with increasing rates in women and the elderly. We aimed to estimate trends in sarcoidosis incidence, prevalence and mortality in Ontario, Canada.<\/p>\n
We performed a cohort study using health administrative data from Ontario between 1996 and 2015. International Classification of Diseases and Ontario Health Insurance Plan codes were used for case detection. Three disease definitions were created; (1) sarcoidosis, >\/=2 physician claims within 2 years; (2) chronic sarcoidosis, >\/=5 physician claims within 3 years; (3) sarcoidosis with histology, >\/=2 physician claims with a tissue biopsy performed between claims.<\/p>\n
\nOverall, 18 550, 9199, and 3819 individuals with sarcoidosis, chronic sarcoidosis and sarcoidosis with histology were identified. The prevalence of sarcoidosis was 143 per 100 000 in 2015, increasing by 116% (p<0.0001) from 1996. The increase in age-adjusted prevalence was higher in men than women (136% versus 99%, p<0.0001). The incidence of sarcoidosis declined from 7.9 to 6.8 per 100 000 between 1996 and 2014 (15% decrease, p=0.0009). A 30.3% decrease in incidence was seen amongst females (p<0.0001), compared to a 5.5% increase in men (p=0.47). Age- and sex-adjusted mortality rates of patients with sarcoidosis rose from 1.15% to 1.47% between 1996 and 2015 (28% increase, p=0.02), with the overall trend being non-significant (p=0.39). Mortality rates in patients with chronic sarcoidosis increased significantly over the study period (p=0.0008).<\/p>\n
\nThe prevalence of sarcoidosis is rising in Ontario, with an apparent shifting trend in disease burden from women to men. Mortality is increasing in patients with chronic sarcoidosis.<\/p>\n","protected":false},"excerpt":{"rendered":"
Sarcoidosis related mortality appears to be rising in North America, with increasing rates in women and the elderly. We aimed to estimate trends in sarcoidosis incidence, prevalence and mortality in Ontario, Canada. We performed a cohort study using health administrative data from Ontario between 1996 and 2015. International Classification of Diseases and Ontario Health Insurance […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-5713","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Fidler LM, Balter M, Fisher JH, To T, Stanbrook MB, Gershon A. Eur Respir J<\/em>. 2019; 54(4):1900444. Epub 2019 Aug 7.","source_url":"http:\/\/doi.org\/10.1183\/13993003.00444-2019","ices_scientist":[1244,1349,1111,20911],"site":[6733],"research_program":[6746],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"885C38DD-9585-4274-B448-0E73B4CFF812","sitecore_item_name":"Epidemiology-and-health-outcomes-of-sarcoidosis-in-a-universal-health-care-population-a-cohort-study","sitecore_field_values":"{\n \"Title\": \"Epidemiology and health outcomes of sarcoidosis in a universal healthcare population: a cohort study\",\n \"Short title\": \"Epidemiology and health outcomes of\",\n \"Summary\": \"This study aimed to estimate trends in sarcoidosis incidence, prevalence and mortality in Ontario, Canada.\",\n \"Citation\": \"