{"id":5578,"date":"2019-09-18T00:00:00","date_gmt":"2019-09-18T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\/"},"modified":"2023-06-14T19:28:49","modified_gmt":"2023-06-14T23:28:49","slug":"atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\/","title":{"rendered":"Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older"},"content":{"rendered":"<p><strong>Aims <\/strong>&#x2014; Atrial fibrillation (AF) is a risk factor for dementia among ischaemic stroke patients in whom the AF was known before the stroke (KAF). Atrial fibrillation detected after stroke (AFDAS) has a different profile compared to KAF, including less frequent cardiovascular comorbidities and lower CHA2-DS2-VASC scores. Currently, it is unknown if AFDAS is also associated with increased dementia risk. We assessed the association between AFDAS and the incident risk of dementia. We also evaluated whether the use of oral anticoagulants (OAC) was associated with lower dementia risk among AFDAS patients.<\/p>\n<p><span class=\"bold\">Methods and Results<\/span> &#x2014; In this cohort study, we classified 9791 first-ever ischaemic stroke patients from the Ontario Stroke Registry into four groups: (i) No AF, (ii) KAF, (iii) Inpatient AFDAS (diagnosed during admission), and (iv) Outpatient AFDAS (diagnosed after discharge). We used multivariable Cox proportional models to estimate hazard ratios (HR) for the association between AFDAS and incident dementia risk. Dementia was determined through administrative datasets based on previously validated algorithms. In adjusted analyses, the dementia risk was higher for inpatient AFDAS [HR 1.78, 95% confidence interval (CI) 1.51-2.10] and outpatient AFDAS (HR 1.74, 95% CI 1.47-2.05) relative to no AF. Oral anticoagulants use was associated with lower dementia risk among patients with inpatient AFDAS (HR 0.58, 95% CI 0.43-0.79) and outpatient AFDAS (HR 0.60, 95% CI 0.43-0.83).<\/p>\n<p><strong>Conclusion <\/strong>&#x2014; Atrial fibrillation detected after stroke was independently associated with higher risk of dementia relative to no AF. Among patients with AFDAS, the use of OACs was associated with lower dementia risk.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aims &#x2014; Atrial fibrillation (AF) is a risk factor for dementia among ischaemic stroke patients in whom the AF was known before the stroke (KAF). Atrial fibrillation detected after stroke (AFDAS) has a different profile compared to KAF, including less frequent cardiovascular comorbidities and lower CHA2-DS2-VASC scores. Currently, it is unknown if AFDAS is also [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-5578","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Krawczyk M, Fridman S, Cheng Y, Fang J, Saposnik G, Sposato LA. <em>Europace<\/em>. 2019; 21(12):1793&#x2013;801. Epub 2019 Sep 18.","source_url":"https:\/\/academic.oup.com\/europace\/advance-article\/doi\/10.1093\/europace\/euz237\/5570193","ices_scientist":[1365],"site":[6733],"research_program":[6742],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"B2E85A13-118D-4E56-B5E1-3153616ED60F","sitecore_item_name":"Atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic","sitecore_field_values":"{\n  \"Title\": \"Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older\",\n  \"Short title\": \"Atrial fibrillation diagnosed after\",\n  \"Summary\": \"This study assessed the association between atrial fibrillation detected after stroke and the incident risk of dementia.\",\n  \"Citation\": \"<p>Krawczyk M, Fridman S, Cheng Y, Fang J, Saposnik G, Sposato LA. <em>Europace<\/em>. 2019; 21(12):1793&ndash;801. Epub 2019 Sep 18. DOI: <a href=\"http:\/\/doi.org\/10.1093\/europace\/euz237\" title=\"opens external link\">10.1093\/europace\/euz237<\/a>.<\/p>\",\n  \"Abstract\": \"<p><strong>Aims <\/strong>&mdash; Atrial fibrillation (AF) is a risk factor for dementia among ischaemic stroke patients in whom the AF was known before the stroke (KAF). Atrial fibrillation detected after stroke (AFDAS) has a different profile compared to KAF, including less frequent cardiovascular comorbidities and lower CHA2-DS2-VASC scores. Currently, it is unknown if AFDAS is also associated with increased dementia risk. We assessed the association between AFDAS and the incident risk of dementia. We also evaluated whether the use of oral anticoagulants (OAC) was associated with lower dementia risk among AFDAS patients.<\/p>n<p><span class=\"bold\">Methods and Results<\/span> &mdash; In this cohort study, we classified 9791 first-ever ischaemic stroke patients from the Ontario Stroke Registry into four groups: (i) No AF, (ii) KAF, (iii) Inpatient AFDAS (diagnosed during admission), and (iv) Outpatient AFDAS (diagnosed after discharge). We used multivariable Cox proportional models to estimate hazard ratios (HR) for the association between AFDAS and incident dementia risk. Dementia was determined through administrative datasets based on previously validated algorithms. In adjusted analyses, the dementia risk was higher for inpatient AFDAS [HR 1.78, 95% confidence interval (CI) 1.51-2.10] and outpatient AFDAS (HR 1.74, 95% CI 1.47-2.05) relative to no AF. Oral anticoagulants use was associated with lower dementia risk among patients with inpatient AFDAS (HR 0.58, 95% CI 0.43-0.79) and outpatient AFDAS (HR 0.60, 95% CI 0.43-0.83).<\/p>n<p><strong>Conclusion <\/strong>&mdash; Atrial fibrillation detected after stroke was independently associated with higher risk of dementia relative to no AF. Among patients with AFDAS, the use of OACs was associated with lower dementia risk.<\/p>n<p><a href=\"https:\/\/academic.oup.com\/europace\/advance-article\/doi\/10.1093\/europace\/euz237\/5570193\" title=\"Opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{9F556094-95ED-4001-9E45-0094CCC54588}\",\n  \"Posted Date\": \"20190918T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2019\/September\/Atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older<\/title>\n<meta name=\"description\" content=\"Aims &#x2014; Atrial fibrillation (AF) is a risk factor for dementia among ischaemic stroke patients in whom the AF was known before the stroke (KAF).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older\" \/>\n<meta property=\"og:description\" content=\"Aims &#x2014; Atrial fibrillation (AF) is a risk factor for dementia among ischaemic stroke patients in whom the AF was known before the stroke (KAF).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T23:28:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/atrial-fibrillation-diagnosed-after-stroke-and-dementia-risk-cohort-study-of-first-ever-ischaemic-stroke-patients-aged-65-or-older\\\/\",\"name\":\"ICES | Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2019-09-18T04:00:00+00:00\",\"dateModified\":\"2023-06-14T23:28:49+00:00\",\"description\":\"Aims &#x2014; 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