{"id":5266,"date":"2012-04-27T00:00:00","date_gmt":"2012-04-27T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/"},"modified":"2023-06-14T19:22:24","modified_gmt":"2023-06-14T23:22:24","slug":"postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/","title":{"rendered":"Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study"},"content":{"rendered":"<p><strong>Objectives<\/strong> &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.<\/p>\n<p><strong>Design<\/strong> &#x2014; Population-based retrospective cohort study.<\/p>\n<p><strong>Setting<\/strong> &#x2014; Ontario, Canada, from April 1, 1998 to March 1, 2008.<\/p>\n<p><strong>Participants<\/strong> &#x2014; A total of 7,804 mothers with publically-funded prescription drug coverage. Women who received a prescription for a codeine-containing product within 7 days following hospital discharge and their neonates were matched to 7,804 mothers who did not receive codeine following delivery.<\/p>\n<p><strong>Main Outcome Measures<\/strong> &#x2014; The primary outcome was readmission of the neonate to hospital for any reason within 30 days. Secondary outcomes included arrival to hospital by ambulance, hospitalization for dehydration, for injury, any hospitalization involving resuscitation or assisted ventilation, and all-cause mortality.<\/p>\n<p><strong>Results<\/strong> &#x2014; The researchers studied 7,804 infants whose mothers filled a prescription for codeine shortly after delivery and 7,804 whose mothers did not. In the primary analysis, infants whose mothers received codeine were no more likely to be readmitted to hospital in the subsequent 30 days than children whose mothers did not (hazard ratio 0.95, 95% confidence interval (CI) 0.81&#x2013;1.11). Moreover, the researchers found no association between maternal codeine use and the other adverse neonatal outcomes studied. A stratified analysis revealed no differential risk among infants born by Caesarian section (hazard ratio 0.86; 95% CI 0.69&#x2013;1.08).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; In this large population-based study, maternal prescription of codeine following delivery was not associated with death or hospitalization in the early neonatal period.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns. Design &#x2014; Population-based retrospective cohort study. Setting &#x2014; Ontario, Canada, from April 1, 1998 to March 1, 2008. Participants &#x2014; A total of 7,804 mothers with publically-funded prescription drug coverage. Women who received a prescription [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[56,31],"migration-helper-qa-sample-set":[],"class_list":["post-5266","journal_article","type-journal_article","status-publish","hentry","topic-pharmacoepidemiology-and-drug-safety","topic-pharmacy"],"acf":{"citation":"Juurlink DN, Gomes T, Guttmann A, Hellings C, Sivilotti ML, Harvey MA, Mamdani MM. <em>Clin Toxicol<\/em>. 2012; 50(5):390-5. Epub 2012 Apr 27.","source_url":"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/15563650.2012.681052","ices_scientist":[1282,1252,1238,1325],"site":[6733,6735],"research_program":[6746,6740],"news_release":[7502],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"58BE99CF-49F7-48DB-87C3-12BAF85B86AA","sitecore_item_name":"Postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes","sitecore_field_values":"{\n  \"Title\": \"Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study\",\n  \"Short title\": \"Postpartum maternal codeine therapy\",\n  \"Citation\": \"<p>Juurlink DN, Gomes T, Guttmann A, Hellings C, Sivilotti ML, Harvey MA, Mamdani MM. <em>Clin Toxicol<\/em>. 2012; 50(5):390-5. Epub 2012 Apr 27.<\/p>\",\n  \"Abstract\": \"<p><strong>Objectives<\/strong> &mdash; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.<\/p>n<p><strong>Design<\/strong> &mdash; Population-based retrospective cohort study.<\/p>n<p><strong>Setting<\/strong> &mdash; Ontario, Canada, from April 1, 1998 to March 1, 2008.<\/p>n<p><strong>Participants<\/strong> &mdash; A total of 7,804 mothers with publically-funded prescription drug coverage. Women who received a prescription for a codeine-containing product within 7 days following hospital discharge and their neonates were matched to 7,804 mothers who did not receive codeine following delivery.<\/p>n<p><strong>Main Outcome Measures<\/strong> &mdash; The primary outcome was readmission of the neonate to hospital for any reason within 30 days. Secondary outcomes included arrival to hospital by ambulance, hospitalization for dehydration, for injury, any hospitalization involving resuscitation or assisted ventilation, and all-cause mortality.<\/p>n<p><strong>Results<\/strong> &mdash; The researchers studied 7,804 infants whose mothers filled a prescription for codeine shortly after delivery and 7,804 whose mothers did not. In the primary analysis, infants whose mothers received codeine were no more likely to be readmitted to hospital in the subsequent 30 days than children whose mothers did not (hazard ratio 0.95, 95% confidence interval (CI) 0.81&ndash;1.11). Moreover, the researchers found no association between maternal codeine use and the other adverse neonatal outcomes studied. A stratified analysis revealed no differential risk among infants born by Caesarian section (hazard ratio 0.86; 95% CI 0.69&ndash;1.08).<\/p>n<p><strong>Conclusions<\/strong> &mdash; In this large population-based study, maternal prescription of codeine following delivery was not associated with death or hospitalization in the early neonatal period.<\/p>n<p><a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/15563650.2012.681052\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{0D3BD683-F179-40A8-924F-D7895622D238}|{84FE2CDF-5B86-4CD1-A954-9886D022974F}\",\n  \"Related Products\": \"<h2>News Release<\/h2>rn<h3><a href=\"~\/link.aspx?_id=B297759939CD406C8BC7B571762DBD26&amp;_z=z\">Postpartum maternal prescription of codeine not a major risk to newborns: study<\/a><\/h3>\",\n  \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}|{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n  \"ICES Scientists\": \"{5268F1B0-EB3E-4577-93DF-3C70C9399847}|{1FA4634A-81DF-4A25-8739-98ABF3872B45}|{DF9D6D4F-1B33-4FB9-AD9B-576798163C2C}|{F2F916BC-2EE9-4C65-BCAB-086ED6BB971A}\",\n  \"Posted Date\": \"20120427T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2012\/January\/Postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study<\/title>\n<meta name=\"description\" content=\"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study\" \/>\n<meta property=\"og:description\" content=\"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T23:22:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\\\/\",\"name\":\"ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2012-04-27T04:00:00+00:00\",\"dateModified\":\"2023-06-14T23:22:24+00:00\",\"description\":\"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Articles\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"name\":\"ICES\",\"description\":\"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\"},\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\",\"name\":\"ICES\",\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"width\":\"676\",\"height\":\"618\",\"caption\":\"ICES\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/ICESOntario\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/ices-research-institute\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study","description":"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/","og_locale":"fr_FR","og_type":"article","og_title":"ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study","og_description":"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.","og_url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/","og_site_name":"ICES","article_publisher":"https:\/\/www.facebook.com\/ICESOntario\/","article_modified_time":"2023-06-14T23:22:24+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/","url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/","name":"ICES | Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study","isPartOf":{"@id":"https:\/\/www.ices.on.ca\/fr\/#website"},"datePublished":"2012-04-27T04:00:00+00:00","dateModified":"2023-06-14T23:22:24+00:00","description":"Objectives &#x2014; To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns.","breadcrumb":{"@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postpartum-maternal-codeine-therapy-and-the-risk-of-adverse-neonatal-outcomes-a-retrospective-cohort-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ices.on.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Journal Articles","item":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/"},{"@type":"ListItem","position":3,"name":"Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study"}]},{"@type":"WebSite","@id":"https:\/\/www.ices.on.ca\/fr\/#website","url":"https:\/\/www.ices.on.ca\/fr\/","name":"ICES","description":"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE","publisher":{"@id":"https:\/\/www.ices.on.ca\/fr\/#organization"},"alternateName":"Institute for Clinical Evaluative Sciences","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ices.on.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ices.on.ca\/fr\/#organization","name":"ICES","alternateName":"Institute for Clinical Evaluative Sciences","url":"https:\/\/www.ices.on.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","contentUrl":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","width":"676","height":"618","caption":"ICES"},"image":{"@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ICESOntario\/","https:\/\/www.linkedin.com\/company\/ices-research-institute\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article\/5266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article"}],"about":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/types\/journal_article"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/news_release\/7502"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6740"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6746"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6735"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6733"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1325"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1238"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1252"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1282"}],"wp:attachment":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/media?parent=5266"}],"wp:term":[{"taxonomy":"migration-helper-automated","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-automated?post=5266"},{"taxonomy":"migration-manual","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-manual?post=5266"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/topic?post=5266"},{"taxonomy":"migration-helper-qa-sample-set","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-qa-sample-set?post=5266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}