{"id":4572,"date":"2018-07-30T00:00:00","date_gmt":"2018-07-30T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/outcomes-of-icds-and-crts-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients\/"},"modified":"2023-06-14T19:52:39","modified_gmt":"2023-06-14T23:52:39","slug":"outcomes-of-icds-and-crts-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/outcomes-of-icds-and-crts-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients\/","title":{"rendered":"Outcomes of ICDs and CRTs in patients with chronic kidney disease: a meta-analysis of 21,000 patients"},"content":{"rendered":"<p><strong>Purpose<\/strong> &#x2014; The efficacy of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in patients with chronic kidney disease (CKD) remains unclear. The aim of this meta-analysis is to explore the association between ICD\/CRT and mortality in CKD patients.&#xa0;<\/p>\n<p><strong>Methods<\/strong> &#x2014; An electronic search was conducted using MEDLINE. We included studies that reported outcomes of interest in CKD patients stratified by the presence of ICD, CRT, or none. The primary outcome was all-cause mortality. Outcomes were pooled using random effects model. Odds ratios (OR) were reported for dichotomous variables.&#xa0;<\/p>\n<p><strong>Results<\/strong> &#x2014; The literature search resulted in 11 studies (observational studies) including 21,136 adult patients: seven studies compared ICD vs. no ICD and four studies compared CRT vs. ICD. All-cause mortality was significantly lower in the ICD group in comparison to that in the no ICD group (OR 0.66 (95% confidence interval [CI] 0.45; 0.98), P = 0.04). Among dialysis-only patients, all-cause mortality was significantly lower in the ICD group (OR 0.49 (95% CI 0.38; 0.64), P &lt; 0.001). All-cause mortality was significantly lower in the CRT group in comparison to that in the ICD group (OR 0.73 (95% CI 0.57; 0.92), P = 0.01).&#xa0;<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; The use of ICDs is associated with lower all-cause mortality in observational studies of CKD patients. CRT use was also associated with lower all-cause mortality in CKD patients in comparison to ICDs. A randomized controlled trial is required to definitively define the role of ICDs\/CRTs in CKD patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Purpose &#x2014; The efficacy of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in patients with chronic kidney disease (CKD) remains unclear. The aim of this meta-analysis is to explore the association between ICD\/CRT and mortality in CKD patients.&#xa0; Methods &#x2014; An electronic search was conducted using MEDLINE. We included studies that reported outcomes [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-4572","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Shurrab M, Ko DT, Zayed Y, Navaneethan SD, Yadak N, Yaseen A, Kaoutskaia A, Qamhia W, Hamdan Z, Haj-Yahia S, Lee DS, Newman D, Healey JS, Harvey P, Crystal E. <em>J Interv Card Electrophysiol. <\/em>2018; 53(1):123-9. Epub 2018 Jul 30.","source_url":"","ices_scientist":[1146,1290,20901],"site":[6733],"research_program":[6742],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"B1E20D58-0E86-435D-930F-9DF4C5962D37","sitecore_item_name":"Outcomes-of-ICDs-and-CRTs-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients","sitecore_field_values":"{\n  \"Title\": \"Outcomes of ICDs and CRTs in patients with chronic kidney disease: a meta-analysis of 21,000 patients\",\n  \"Short title\": \"Outcomes of ICDs and CRTs\",\n  \"Summary\": \"This meta-analysis explores the association between implantable cardioverter defibrillator\/cardiac resynchronization therapy and mortality in chronic kidney disease patients. \",\n  \"Citation\": \"<p>Shurrab M, Ko DT, Zayed Y, Navaneethan SD, Yadak N, Yaseen A, Kaoutskaia A, Qamhia W, Hamdan Z, Haj-Yahia S, Lee DS, Newman D, Healey JS, Harvey P, Crystal E. <em>J Interv Card Electrophysiol. <\/em>2018; 53(1):123-9. Epub 2018 Jul 30.<\/p>\",\n  \"Abstract\": \"<p><strong>Purpose<\/strong> &mdash; The efficacy of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in patients with chronic kidney disease (CKD) remains unclear. The aim of this meta-analysis is to explore the association between ICD\/CRT and mortality in CKD patients.&nbsp;<\/p>n<p><strong>Methods<\/strong> &mdash; An electronic search was conducted using MEDLINE. We included studies that reported outcomes of interest in CKD patients stratified by the presence of ICD, CRT, or none. The primary outcome was all-cause mortality. Outcomes were pooled using random effects model. Odds ratios (OR) were reported for dichotomous variables.&nbsp;<\/p>n<p><strong>Results<\/strong> &mdash; The literature search resulted in 11 studies (observational studies) including 21,136 adult patients: seven studies compared ICD vs. no ICD and four studies compared CRT vs. ICD. All-cause mortality was significantly lower in the ICD group in comparison to that in the no ICD group (OR 0.66 (95% confidence interval [CI] 0.45; 0.98), P = 0.04). Among dialysis-only patients, all-cause mortality was significantly lower in the ICD group (OR 0.49 (95% CI 0.38; 0.64), P &lt; 0.001). All-cause mortality was significantly lower in the CRT group in comparison to that in the ICD group (OR 0.73 (95% CI 0.57; 0.92), P = 0.01).&nbsp;<\/p>n<p><strong>Conclusions<\/strong> &mdash; The use of ICDs is associated with lower all-cause mortality in observational studies of CKD patients. CRT use was also associated with lower all-cause mortality in CKD patients in comparison to ICDs. A randomized controlled trial is required to definitively define the role of ICDs\/CRTs in CKD patients.<\/p>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{B3827152-93D1-4FB2-B106-590CB331A264}|{CEEE13AD-C7DE-455F-ACF8-AAD7D27BB178}\",\n  \"Posted Date\": \"20180730T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2018\/July\/Outcomes-of-ICDs-and-CRTs-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Outcomes of ICDs and CRTs in patients with chronic kidney disease: a meta-analysis of 21,000 patients<\/title>\n<meta name=\"description\" content=\"Purpose &#x2014; The efficacy of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in patients with chronic kidney\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/outcomes-of-icds-and-crts-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-21000-patients\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Outcomes of ICDs and CRTs in patients with chronic kidney disease: a meta-analysis of 21,000 patients\" \/>\n<meta property=\"og:description\" content=\"Purpose &#x2014; 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