{"id":4283,"date":"2015-06-29T00:00:00","date_gmt":"2015-06-29T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/variability-in-antibiotic-use-across-nursing-homes-and-the-risk-of-antibiotic-related-adverse-outcomes-for-individual-residents\/"},"modified":"2023-06-14T19:26:47","modified_gmt":"2023-06-14T23:26:47","slug":"variability-in-antibiotic-use-across-nursing-homes-and-the-risk-of-antibiotic-related-adverse-outcomes-for-individual-residents","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/variability-in-antibiotic-use-across-nursing-homes-and-the-risk-of-antibiotic-related-adverse-outcomes-for-individual-residents\/","title":{"rendered":"Variability in antibiotic use across nursing homes and the risk of antibiotic-related adverse outcomes for individual residents"},"content":{"rendered":"<p><strong>Importance <\/strong>&#x2014; Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks to recipients and indirect risks to others residing in the home.<\/p>\n<p><strong>Objective <\/strong>&#x2014; To examine whether living in a nursing home with high antibiotic use is associated with an increased risk of antibiotic-related adverse outcomes for individual residents.<\/p>\n<p><span class=\"bold\">Design, Setting and Participants<\/span> &#x2014; In this longitudinal open-cohort study performed from January 1, 2010, through December 31, 2011, we studied 110 656 older adults residing in 607 nursing homes in Ontario, Canada.<\/p>\n<p><strong>Exposures<\/strong> &#x2014; Nursing home-level antibiotic use was defined as use-days per 1,000 resident-days, and facilities were classified as high, medium and low use according to tertile of use. Multivariable logistic regression modeling was performed to assess the impact of nursing home level antibiotic use on the individual risk of antibiotic-related adverse outcomes.<\/p>\n<p><span class=\"bold\">Main Outcomes and Measures <\/span>&#x2014; Antibiotic-related harms included Clostridium difficile, diarrhea or gastroenteritis, antibiotic-resistant organisms (which can directly affect recipients and indirectly affect nonrecipients), allergic reactions and general medication adverse events (which can affect only recipients).<\/p>\n<p><strong>Results <\/strong>&#x2014; Antibiotics were provided on 2&#x202f;783&#x202f;000 of 50&#x202f;953&#x202f;000 resident-days in nursing homes (55 antibiotic-days per 1000 resident-days). Antibiotic use was highly variable across homes, ranging from 20.4 to 192.9 antibiotic-days per 1000 resident-days. Antibiotic-related adverse events were more common (13.3%) in residents of high-use homes than among residents of medium-use (12.4%) or low-use homes (11.4%) (P&#x2009;&lt;&#x2009;.001); this trend persisted even among the residents who did not receive antibiotic treatments. The primary analysis indicated that residence in a high-use nursing home was associated with an increased risk of a resident experiencing an antibiotic-related adverse event (adjusted odds ratio, 1.24; 95% CI, 1.07-1.42; P&#x2009;=&#x2009;.003). A sensitivity analysis examining nursing home-level antibiotic use as a continuous variable confirmed an increased risk of resident-level antibiotic-related harms (adjusted odds ratio, 1.004 per additional day of nursing home antibiotic use; 95% CI, 1.001-1.006; P&#x2009;=&#x2009;.01)..<\/p>\n<p><span class=\"bold\">Conclusions and Relevance <\/span>&#x2014; Antibiotic use is highly variable across nursing homes; residents of high-use homes are exposed to an increased risk of antibiotic-related harms even if they have not directly received these agents. Antibiotic stewardship is needed to improve the safety of all nursing home residents.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance &#x2014; Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks to recipients and indirect risks to others residing in the home. Objective &#x2014; To examine whether living in a nursing home with high antibiotic use is associated with an increased risk of antibiotic-related adverse outcomes for [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[33,56],"migration-helper-qa-sample-set":[],"class_list":["post-4283","journal_article","type-journal_article","status-publish","hentry","topic-end-of-life-care","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Daneman N, Bronskill SE, Gruneir A, Newman AM, Fischer HD, Rochon PA, Anderson GM, Bell CM. <em>JAMA Intern Med. <\/em>2015; 175(8):1331-9. Epub 2015 Jun 29.","source_url":"http:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2337257","ices_scientist":[1215,1159,1245,1340,1172,1382,17132],"site":[6733,6735],"research_program":[6740,6746],"news_release":[7826],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"74C3B989-9F90-481B-BB0A-2803A5D06B2C","sitecore_item_name":"Variability-in-antibiotic-use-across-nursing-homes-and-the-risk","sitecore_field_values":"{\n  \"__Valid from\": \"20170727T134416\",\n  \"Title\": \"Variability in antibiotic use across nursing homes and the risk of antibiotic-related adverse outcomes for individual residents\",\n  \"Short title\": \"Variability in antibiotic use across\",\n  \"Summary\": \"Antibiotic prescriptions are frequent, and frequently inappropriate, in nursing homes. These antibiotics pose direct risks to recipients, and indirect risks to others residing in the home.\",\n  \"Citation\": \"<p>Daneman N, Bronskill SE, Gruneir A, Newman AM, Fischer HD, Rochon PA, Anderson GM, Bell CM. <em>JAMA Intern Med. <\/em>2015; 175(8):1331-9. Epub 2015 Jun 29.<\/p>\",\n  \"Abstract\": \"<p><strong>Importance <\/strong>&mdash; Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks to recipients and indirect risks to others residing in the home.<\/p>n<p><strong>Objective <\/strong>&mdash; To examine whether living in a nursing home with high antibiotic use is associated with an increased risk of antibiotic-related adverse outcomes for individual residents.<\/p>n<p><span class=\"bold\">Design, Setting and Participants<\/span> &mdash; In this longitudinal open-cohort study performed from January 1, 2010, through December 31, 2011, we studied 110 656 older adults residing in 607 nursing homes in Ontario, Canada.<\/p>n<p><strong>Exposures<\/strong> &mdash; Nursing home-level antibiotic use was defined as use-days per 1,000 resident-days, and facilities were classified as high, medium and low use according to tertile of use. Multivariable logistic regression modeling was performed to assess the impact of nursing home level antibiotic use on the individual risk of antibiotic-related adverse outcomes.<\/p>n<p><span class=\"bold\">Main Outcomes and Measures <\/span>&mdash; Antibiotic-related harms included Clostridium difficile, diarrhea or gastroenteritis, antibiotic-resistant organisms (which can directly affect recipients and indirectly affect nonrecipients), allergic reactions and general medication adverse events (which can affect only recipients).<\/p>n<p><strong>Results <\/strong>&mdash; Antibiotics were provided on 2\u202f783\u202f000 of 50\u202f953\u202f000 resident-days in nursing homes (55 antibiotic-days per 1000 resident-days). Antibiotic use was highly variable across homes, ranging from 20.4 to 192.9 antibiotic-days per 1000 resident-days. Antibiotic-related adverse events were more common (13.3%) in residents of high-use homes than among residents of medium-use (12.4%) or low-use homes (11.4%) (P&thinsp;&lt;&thinsp;.001); this trend persisted even among the residents who did not receive antibiotic treatments. The primary analysis indicated that residence in a high-use nursing home was associated with an increased risk of a resident experiencing an antibiotic-related adverse event (adjusted odds ratio, 1.24; 95% CI, 1.07-1.42; P&thinsp;=&thinsp;.003). A sensitivity analysis examining nursing home-level antibiotic use as a continuous variable confirmed an increased risk of resident-level antibiotic-related harms (adjusted odds ratio, 1.004 per additional day of nursing home antibiotic use; 95% CI, 1.001-1.006; P&thinsp;=&thinsp;.01)..<\/p>n<p><span class=\"bold\">Conclusions and Relevance <\/span>&mdash; Antibiotic use is highly variable across nursing homes; residents of high-use homes are exposed to an increased risk of antibiotic-related harms even if they have not directly received these agents. Antibiotic stewardship is needed to improve the safety of all nursing home residents.<\/p>n<p><a href=\"http:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2337257\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{43CD54EE-583B-4D2D-BA6B-DAC3B29A9E23}|{6F47479A-93B4-40A0-A72C-7D6B55EEC91A}|{8B171BCD-F63E-4950-9C0D-FA00417F685C}\",\n  \"Related Products\": \"<h2>News Release<\/h2>rn<h3><a href=\"~\/link.aspx?_id=FF066A86DF064B72AD3B186038B66B16&amp;_z=z\">Residents of nursing homes with high antibiotic use are at higher risk of antibiotic-related adverse events <\/a><\/h3>rn<h2>ICES in the News<\/h2>rn<h3><a href=\"http:\/\/www.cbc.ca\/news\/health\/heavy-use-of-antibiotics-in-nursing-homes-may-raise-risk-for-all-residents-1.3132458\" title=\"External link to CBC website opens in new window\" target=\"_blank\">Heavy use of antibiotics in nursing homes may raise risk for all residents<\/a><\/h3>\",\n  \"Research Programs\": \"{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}|{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n  \"ICES Scientists\": \"{AB44D37A-7B8D-4D5E-80E9-092E8FC19B8E}|{68FD9EE5-974B-4CED-A597-82186232FF1D}|{54306858-3CB9-4AF1-920F-9B0BE028DD82}|{14B76C34-3A35-4785-86C4-9B1633E28765}|{9F60496B-63FD-4BE5-A7EF-C4969D7AACB3}|{38899D1B-38E7-4517-8DA3-0BDDF1F9944D}\",\n  \"Posted Date\": \"20150629T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2015\/January\/Variability-in-antibiotic-use-across-nursing-homes-and-the-risk"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Variability in antibiotic use across nursing homes and the risk of antibiotic-related adverse outcomes for individual residents<\/title>\n<meta name=\"description\" content=\"Importance &#x2014; Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. 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