{"id":4207,"date":"2015-07-27T00:00:00","date_gmt":"2015-07-27T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/risk-of-dementia-in-seniors-with-newly-diagnosed-diabetes-a-population-based-study\/"},"modified":"2023-06-14T20:03:47","modified_gmt":"2023-06-15T00:03:47","slug":"risk-of-dementia-in-seniors-with-newly-diagnosed-diabetes-a-population-based-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/risk-of-dementia-in-seniors-with-newly-diagnosed-diabetes-a-population-based-study\/","title":{"rendered":"Risk of dementia in seniors with newly diagnosed diabetes: a population-based study"},"content":{"rendered":"

Objective<\/strong> — To study whether diabetes onset in late life is a risk factor for dementia.<\/p>\n

Research Design and Methods<\/span> — We conducted a population-based matched cohort study using provincial health data from Ontario, Canada. Seniors with (n = 225,045) and without newly diagnosed diabetes (n = 668,070) between April 1995 and March 2007 were followed until March 2012 for a new diagnosis of dementia. Cox proportional hazards modeling was used to compare the risk of dementia between groups after adjusting for baseline cardiovascular disease, chronic kidney disease (CKD), hypertension, and other risk factors.<\/p>\n

Results<\/strong> — Over this period, we observed 169,114 new cases of dementia. Individuals with diabetes had a modestly higher incidence of dementia (2.68 vs. 2.62 per 100 person-years) than those without diabetes. In the fully adjusted Cox model, the risk of dementia was 16% higher among our subgroup with diabetes (hazard ratio [HR] 1.16 [95% CI 1.15-1.18]). Adjusted HRs for dementia were 1.20 (95% CI 1.17-1.22) and 1.14 (95% CI 1.12-1.16) among men and women, respectively. Among seniors with diabetes, the risk of dementia was greatest in those with prior cerebrovascular disease (HR 2.03; 95% CI 1.88-2.19), peripheral vascular disease (HR 1.47; 95% CI 1.19-1.82), and CKD (HR 1.44; 95% CI 1.38-1.51), and those with one or more hospital visits for hypoglycemia (HR 1.73; 95% CI 1.62-1.84).<\/p>\n

Conclusions<\/strong> — In this population-based study, newly diagnosed diabetes was associated with a 16% increase in the risk of dementia among seniors. Preexisting vascular disease and severe hypoglycemia were the greatest risk factors for dementia in seniors with diabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Objective — To study whether diabetes onset in late life is a risk factor for dementia. Research Design and Methods — We conducted a population-based matched cohort study using provincial health data from Ontario, Canada. Seniors with (n = 225,045) and without newly diagnosed diabetes (n = 668,070) between April 1995 and March 2007 were […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,50,17],"migration-helper-qa-sample-set":[],"class_list":["post-4207","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-endocrinology","topic-older-people"],"acf":{"citation":"Haroon NN, Austin PC, Shah BR, Wu J, Gill SS, Booth GL. Diabetes Care<\/em>. 2015; 38(10):1868-75. Epub 2015 Jul 27.","source_url":"http:\/\/care.diabetesjournals.org\/content\/38\/10\/1868.long","ices_scientist":[1385,1361,1251,1175],"site":[6733,6736],"research_program":[6742,6746],"news_release":[7834],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"5B0C4DEC-B3CB-4E9C-AB15-CF68DC86D28E","sitecore_item_name":"Risk-of-dementia-in-seniors-with-newly-diagnosed-diabetes","sitecore_field_values":"{\n \"__Valid from\": \"20170726T161220\",\n \"Title\": \"Risk of dementia in seniors with newly diagnosed diabetes: a population-based study\",\n \"Short title\": \"Risk of dementia in seniors with\",\n \"Summary\": \"The objective of the study was to determine whether diabetes onset in late life is a risk factor for dementia.\",\n \"Citation\": \"

Haroon NN, Austin PC, Shah BR, Wu J, Gill SS, Booth GL. Diabetes Care<\/em>. 2015; 38(10):1868-75. Epub 2015 Jul 27. <\/p>\",\n \"Abstract\": \"

Objective<\/strong> — To study whether diabetes onset in late life is a risk factor for dementia.<\/p>n

Research Design and Methods<\/span> — We conducted a population-based matched cohort study using provincial health data from Ontario, Canada. Seniors with (n = 225,045) and without newly diagnosed diabetes (n = 668,070) between April 1995 and March 2007 were followed until March 2012 for a new diagnosis of dementia. Cox proportional hazards modeling was used to compare the risk of dementia between groups after adjusting for baseline cardiovascular disease, chronic kidney disease (CKD), hypertension, and other risk factors.<\/p>n

Results<\/strong> — Over this period, we observed 169,114 new cases of dementia. Individuals with diabetes had a modestly higher incidence of dementia (2.68 vs. 2.62 per 100 person-years) than those without diabetes. In the fully adjusted Cox model, the risk of dementia was 16% higher among our subgroup with diabetes (hazard ratio [HR] 1.16 [95% CI 1.15-1.18]). Adjusted HRs for dementia were 1.20 (95% CI 1.17-1.22) and 1.14 (95% CI 1.12-1.16) among men and women, respectively. Among seniors with diabetes, the risk of dementia was greatest in those with prior cerebrovascular disease (HR 2.03; 95% CI 1.88-2.19), peripheral vascular disease (HR 1.47; 95% CI 1.19-1.82), and CKD (HR 1.44; 95% CI 1.38-1.51), and those with one or more hospital visits for hypoglycemia (HR 1.73; 95% CI 1.62-1.84).<\/p>n

Conclusions<\/strong> — In this population-based study, newly diagnosed diabetes was associated with a 16% increase in the risk of dementia among seniors. Preexisting vascular disease and severe hypoglycemia were the greatest risk factors for dementia in seniors with diabetes.<\/p>n

View full text<\/a><\/p>\",\n \"Keywords\": \"{26EB1DB1-6793-4CB3-9CFB-DFF37E09FB5A}|{AD1C8354-D3A0-4679-8E69-7A79EFFE3607}|{890D768C-539D-4026-A09D-89F697736911}\",\n \"Related Products\": \"

NEWS RELEASE<\/h2>rn

Being diagnosed with diabetes late in life associated with higher risk of developing dementia, new study indicates<\/a><\/h3>\",\n \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}|{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{5A12C65D-3CDA-413E-BC94-C1D778156CE6}\",\n \"ICES Scientists\": \"{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{4CA3655C-D15C-43EC-8F5D-9FE401C24F27}|{5B2D929C-DA9B-45B8-8DAA-8150B2E76063}|{98B8617F-C6B9-4032-9C0D-7053D3651ABA}\",\n \"Posted Date\": \"20150727T000000\",\n \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2015\/January\/Risk-of-dementia-in-seniors-with-newly-diagnosed-diabetes"},"yoast_head":"\nICES | Risk of dementia in seniors with newly diagnosed diabetes: a population-based study<\/title>\n<meta name=\"description\" content=\"Objective — To study whether diabetes onset in late life is a risk factor for dementia. 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