{"id":4081,"date":"2013-06-28T00:00:00","date_gmt":"2013-06-28T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/risk-of-guillain-barre-syndrome-after-seasonal-influenza-vaccination-and-influenza-health-care-encounters-a-self-controlled-study\/"},"modified":"2023-06-14T20:13:23","modified_gmt":"2023-06-15T00:13:23","slug":"risk-of-guillain-barre-syndrome-after-seasonal-influenza-vaccination-and-influenza-health-care-encounters-a-self-controlled-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/risk-of-guillain-barre-syndrome-after-seasonal-influenza-vaccination-and-influenza-health-care-encounters-a-self-controlled-study\/","title":{"rendered":"Risk of Guillain-Barr\u00e9 syndrome after seasonal influenza vaccination and influenza health-care encounters: a self-controlled study"},"content":{"rendered":"

Background<\/strong> — The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Guillain-Barré syndrome. The researchers aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters.<\/p>\n

Methods<\/strong> — The researchers used the self-controlled risk interval design and linked universal health-care system databases from Ontario, Canada, with data obtained between 1993 and 2011. The researchers used physician billing claims for influenza vaccination and influenza-coded health-care encounters to ascertain exposures. Using fixed-effects conditional Poisson regression, the researchers estimated the relative incidence of hospitalisation for primary-coded Guillain-Barré syndrome during the risk interval compared with the control interval.<\/p>\n

Findings<\/strong> — The researchers identified 2831 incident admissions for Guillain-Barré syndrome; 330 received an influenza vaccine and 109 had an influenza-coded health-care encounter within 42 weeks before hospitalisation. The risk of Guillain-Barré syndrome within 6 weeks of vaccination was 52% higher than in the control interval of 9–42 weeks (relative incidence 1.52; 95% CI 1.17–1.99), with the greatest risk during weeks 2–4 after vaccination. The risk of Guillain-Barré syndrome within 6 weeks of an influenza-coded health-care encounter was greater than for vaccination (15.81; 10.28–24.32). The attributable risks were 1.03 Guillain-Barré syndrome admissions per million vaccinations, compared with 17.2 Guillain-Barré syndrome admissions per million influenza-coded health-care encounters.<\/p>\n

Interpretation<\/strong> — The relative and attributable risks of Guillain-Barré syndrome after seasonal influenza vaccination are lower than those after influenza illness. Patients considering immunisation should be fully informed of the risks of Guillain-Barré syndrome from both influenza vaccines and influenza illness.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background — The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Guillain-Barré syndrome. The researchers aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters. Methods — The researchers used the […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,39],"migration-helper-qa-sample-set":[],"class_list":["post-4081","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-infectious-diseases"],"acf":{"citation":"Kwong JC, Vasa PP, Campitelli MA, Hawken S, Wilson K, Rosella LC, Stukel TA, Crowcroft NS, McGeer AJ, Zinman L, Deeks SL. Lancet<\/em>. 2013; 13(9):769-76. Epub 2013 Jun 28.","source_url":"","ices_scientist":[1149,1339,1372,1260,1207],"site":[6734,6735,6733],"research_program":[6740],"news_release":[7412],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"B328C082-EABD-49BD-8266-FB8478F43DA4","sitecore_item_name":"Risk-of-Guillain-Barr-syndrome-after-seasonal-influenza-vaccination-and-influenza-health-care","sitecore_field_values":"{\n \"Title\": \"Risk of Guillain-Barr\u00e9 syndrome after seasonal influenza vaccination and influenza health-care encounters: a self-controlled study\",\n \"Short title\": \"Risk of Guillain-Barr\u00e9 syndrome\",\n \"Citation\": \"

Kwong JC, Vasa PP, Campitelli MA, Hawken S, Wilson K, Rosella LC, Stukel TA, Crowcroft NS, McGeer AJ, Zinman L, Deeks SL. Lancet<\/em>. 2013; 13(9):769-76. Epub 2013 Jun 28.<\/p>\",\n \"Abstract\": \"

Background<\/strong> — The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Guillain-Barré syndrome. The researchers aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters.<\/p>n

Methods<\/strong> — The researchers used the self-controlled risk interval design and linked universal health-care system databases from Ontario, Canada, with data obtained between 1993 and 2011. The researchers used physician billing claims for influenza vaccination and influenza-coded health-care encounters to ascertain exposures. Using fixed-effects conditional Poisson regression, the researchers estimated the relative incidence of hospitalisation for primary-coded Guillain-Barré syndrome during the risk interval compared with the control interval.<\/p>n

Findings<\/strong> — The researchers identified 2831 incident admissions for Guillain-Barré syndrome; 330 received an influenza vaccine and 109 had an influenza-coded health-care encounter within 42 weeks before hospitalisation. The risk of Guillain-Barré syndrome within 6 weeks of vaccination was 52% higher than in the control interval of 9–42 weeks (relative incidence 1.52; 95% CI 1.17–1.99), with the greatest risk during weeks 2–4 after vaccination. The risk of Guillain-Barré syndrome within 6 weeks of an influenza-coded health-care encounter was greater than for vaccination (15.81; 10.28–24.32). The attributable risks were 1.03 Guillain-Barré syndrome admissions per million vaccinations, compared with 17.2 Guillain-Barré syndrome admissions per million influenza-coded health-care encounters.<\/p>n

Interpretation<\/strong> — The relative and attributable risks of Guillain-Barré syndrome after seasonal influenza vaccination are lower than those after influenza illness. Patients considering immunisation should be fully informed of the risks of Guillain-Barré syndrome from both influenza vaccines and influenza illness.<\/p>\",\n \"Keywords\": \"{65D0A3C1-88FE-4F8F-B010-9B643FDA1A82}|{A5F436B7-3935-4915-ABFB-160DCA0AB95E}\",\n \"Related Products\": \"

News Release<\/h2>rn

The risk of contracting Guillain-Barré Syndrome is greater after getting the flu, not the flu shot<\/a><\/h3>\",\n \"Research Programs\": \"{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}|{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n \"ICES Locations\": \"{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}|{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}|{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n \"ICES Scientists\": \"{14489280-87E2-4E37-BCF5-35BDF557014F}|{27680717-A18A-415F-82BB-D193C9AABE27}|{430B2731-D3D6-4D57-9AF4-AA7626CF61B0}|{A0978F87-1C10-4E62-A833-89616146CA59}|{C3E4F5EF-B2E3-40B3-8FFB-9BE638B8F35B}|{A63E52B6-A1CB-4479-9F43-492E65695C5B}|{7325515F-322B-448F-B845-746353A3DD14}\",\n \"Posted Date\": \"20130628T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2013\/January\/Risk-of-Guillain-Barr-syndrome-after-seasonal-influenza-vaccination-and-influenza-health-care"},"yoast_head":"\nICES | Risk of Guillain-Barr\u00e9 syndrome after seasonal influenza vaccination and 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