{"id":4024,"date":"2013-05-14T00:00:00","date_gmt":"2013-05-14T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\/"},"modified":"2023-06-14T19:25:59","modified_gmt":"2023-06-14T23:25:59","slug":"diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\/","title":{"rendered":"Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome (ACS), but recent data about the risk of new-onset diabetes have raised concern about its use. The authors&apos; main objective was to evaluate the association between intensive statin therapy and new-onset diabetes in myocardial infarction patients, and to evaluate the association of intensive statin therapy with long-term adverse clinical outcomes.<\/p>\n<p><span class=\"bold\">Methods and Results<\/span> &#x2014; A propensity score matched cohort was created consisting of 17,080 patients older than 65 years old, hospitalized with a myocardial infarction in Ontario, Canada from 2004 to 2010. Clinical outcomes were compared in patients prescribed intensive-dose versus moderate-dose statins at hospital discharge. At 5 years, 13.6% of patients receiving intensive-dose statins and 13.0% of patients receiving moderate-dose statins had new-onset diabetes, which was not significantly different (p = 0.19). By contrast, the 5-year rate of death or ACS was significantly lower at 44.8% in the intensive-dose statin group compared with 46.5% in the moderate-dose group (p = 0.044). The reduction in combined clinical outcome was driven mainly by a significantly lower rate of ACS (p = 0.039) associated with intensive-dose statins. No significant difference in mortality rates (34.8% in both groups) was observed between the treatment groups during the study period (p = 0.89).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; In older patients with myocardial infarction, the authors found intensive-dose statin therapy to be effective in reducing repeat hospitalization for ACS. The rate of new-onset diabetes at long term was not significantly different between intensive-dose and moderate-dose statins.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome (ACS), but recent data about the risk of new-onset diabetes have raised concern about its use. The authors&apos; main objective was to evaluate the association between intensive statin therapy and new-onset diabetes in myocardial infarction patients, and to evaluate the association of [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,50,56],"migration-helper-qa-sample-set":[],"class_list":["post-4024","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-endocrinology","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Ko DT, Wijeysundera H, Jackevicius CA, Wang J, Tu JV. <em>Circ Cardiovasc Qual Outcomes<\/em>. 2013; 6(3):315-22. Epub 2013 May 14.","source_url":"http:\/\/circoutcomes.ahajournals.org\/content\/6\/3\/315.long","ices_scientist":[1146,1133,1281],"site":[6733],"research_program":[6742],"news_release":[7445],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"630B2DE9-FEA0-4501-B982-23DF4005F4D2","sitecore_item_name":"Diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed","sitecore_field_values":"{\n  \"Title\": \"Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins\",\n  \"Short title\": \"Diabetes mellitus and cardiovascular\",\n  \"Citation\": \"<p>Ko DT, Wijeysundera H, Jackevicius CA, Wang J, Tu JV. <em>Circ Cardiovasc Qual Outcomes<\/em>. 2013; 6(3):315-22. Epub 2013 May 14.<\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome (ACS), but recent data about the risk of new-onset diabetes have raised concern about its use. The authors' main objective was to evaluate the association between intensive statin therapy and new-onset diabetes in myocardial infarction patients, and to evaluate the association of intensive statin therapy with long-term adverse clinical outcomes.<\/p>n<p><span class=\"bold\">Methods and Results<\/span> &mdash; A propensity score matched cohort was created consisting of 17,080 patients older than 65 years old, hospitalized with a myocardial infarction in Ontario, Canada from 2004 to 2010. Clinical outcomes were compared in patients prescribed intensive-dose versus moderate-dose statins at hospital discharge. At 5 years, 13.6% of patients receiving intensive-dose statins and 13.0% of patients receiving moderate-dose statins had new-onset diabetes, which was not significantly different (p = 0.19). By contrast, the 5-year rate of death or ACS was significantly lower at 44.8% in the intensive-dose statin group compared with 46.5% in the moderate-dose group (p = 0.044). The reduction in combined clinical outcome was driven mainly by a significantly lower rate of ACS (p = 0.039) associated with intensive-dose statins. No significant difference in mortality rates (34.8% in both groups) was observed between the treatment groups during the study period (p = 0.89).<\/p>n<p><strong>Conclusions<\/strong> &mdash; In older patients with myocardial infarction, the authors found intensive-dose statin therapy to be effective in reducing repeat hospitalization for ACS. The rate of new-onset diabetes at long term was not significantly different between intensive-dose and moderate-dose statins.<\/p>n<p><a href=\"http:\/\/circoutcomes.ahajournals.org\/content\/6\/3\/315.long\" title=\"Opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{26EB1DB1-6793-4CB3-9CFB-DFF37E09FB5A}|{92E2791D-5DAB-4244-8A85-434D524D9A12}|{B711DE54-5056-420D-AA0E-1349F1D88049}\",\n  \"Related Products\": \"<h2>News Release<\/h2>rn<h3><a href=\"~\/link.aspx?_id=B6BA7C2208994B8382B98A2F3071E8BA&amp;_z=z\">Intensive-dose statin therapy reduces hospitalization rates in older Ontarians who have had a heart attack<\/a><\/h3>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{B3827152-93D1-4FB2-B106-590CB331A264}|{8C2597F4-2B41-4E87-9F28-6887C689651B}|{BA86E62A-3468-443D-939F-34A9EFA7B7AA}|{956599EC-5699-41D3-9375-E0B6C25B12D5}\",\n  \"Posted Date\": \"20130514T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2013\/January\/Diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome (ACS), but recent data about the risk\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; Practice guidelines recommend intensive-dose statins for patients with acute coronary syndrome (ACS), but recent data about the risk\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T23:25:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/diabetes-mellitus-and-cardiovascular-events-in-older-patients-with-myocardial-infarction-prescribed-intensive-dose-and-moderate-dose-statins\\\/\",\"name\":\"ICES | Diabetes mellitus and cardiovascular events in older patients with myocardial infarction prescribed intensive-dose and moderate-dose statins\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2013-05-14T04:00:00+00:00\",\"dateModified\":\"2023-06-14T23:25:59+00:00\",\"description\":\"Background &#x2014; 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