{"id":3864,"date":"2000-05-16T00:00:00","date_gmt":"2000-05-16T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/"},"modified":"2023-06-14T20:05:55","modified_gmt":"2023-06-15T00:05:55","slug":"postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/","title":{"rendered":"Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic cholecystitis. We set out to confirm the relation between recent estrogen use and cholecystectomy in postmenopausal women and to test the novel hypothesis that a similar relation exists for appendectomy.<\/p>\n<p><strong>Methods<\/strong> &#x2014; We developed a retrospective cohort using prescribing and surgical procedure information from health administrative databases for approximately 800 000 female residents of Ontario who were over 65 years of age between July 1, 1993, and Mar. 31, 1998. We compared the incidence of cholecystectomy and appendectomy among women recently prescribed estrogen replacement therapy, levothyroxine and dihydropyridine calcium-channel antagonists (DCCA) using age-adjusted Cox proportional hazards models. Patients were followed for a mean of 540 (standard deviation [SD] 449) days.<\/p>\n<p><strong>Results<\/strong> &#x2014; Compared with women taking DCCA, those who had recently begun taking estrogen were significantly more likely to undergo cholecystectomy (age-adjusted risk ratio [aRR] 1.9, 95% confidence interval [CI] 1.6-2.2) and appendectomy (aRR 1.8, 95% CI 1.1-3.0). No significant difference in either outcome measure was found between the levothyroxine users and the DCCA users.<\/p>\n<p><strong>Interpretation<\/strong> &#x2014; This study identifies an increased risk of cholecystectomy and appendectomy among postmenopausal women who have recently begun estrogen replacement therapy. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic cholecystitis. We set out to confirm the relation between recent estrogen use and cholecystectomy in postmenopausal women and to test the novel hypothesis that a similar relation exists for appendectomy. Methods &#x2014; We developed a retrospective [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[17,56],"migration-helper-qa-sample-set":[],"class_list":["post-3864","journal_article","type-journal_article","status-publish","hentry","topic-older-people","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Mamdani MM, Tu K, van Walraven C, Austin PC, Naylor CD. <em>CMAJ<\/em>. 2000; 162(10):1421-4.","source_url":"http:\/\/www.cmaj.ca\/content\/162\/10\/1421.long","ices_scientist":[1325,1119,1385,1304],"site":[6735,6733,6734],"research_program":[6742,6746],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"DF54B18D-ABA0-441E-8905-D8ED5B15055D","sitecore_item_name":"Postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy","sitecore_field_values":"{\n  \"Title\": \"Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy\",\n  \"Short title\": \"Postmenopausal estrogen replacement\",\n  \"Citation\": \"<p>Mamdani MM, Tu K, van Walraven C, Austin PC, Naylor CD. <em>CMAJ<\/em>. 2000; 162(10):1421-4.<\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic cholecystitis. We set out to confirm the relation between recent estrogen use and cholecystectomy in postmenopausal women and to test the novel hypothesis that a similar relation exists for appendectomy.<\/p>n<p><strong>Methods<\/strong> &mdash; We developed a retrospective cohort using prescribing and surgical procedure information from health administrative databases for approximately 800 000 female residents of Ontario who were over 65 years of age between July 1, 1993, and Mar. 31, 1998. We compared the incidence of cholecystectomy and appendectomy among women recently prescribed estrogen replacement therapy, levothyroxine and dihydropyridine calcium-channel antagonists (DCCA) using age-adjusted Cox proportional hazards models. Patients were followed for a mean of 540 (standard deviation [SD] 449) days.<\/p>n<p><strong>Results<\/strong> &mdash; Compared with women taking DCCA, those who had recently begun taking estrogen were significantly more likely to undergo cholecystectomy (age-adjusted risk ratio [aRR] 1.9, 95% confidence interval [CI] 1.6-2.2) and appendectomy (aRR 1.8, 95% CI 1.1-3.0). No significant difference in either outcome measure was found between the levothyroxine users and the DCCA users.<\/p>n<p><strong>Interpretation<\/strong> &mdash; This study identifies an increased risk of cholecystectomy and appendectomy among postmenopausal women who have recently begun estrogen replacement therapy. <\/p>n<p><a href=\"http:\/\/www.cmaj.ca\/content\/162\/10\/1421.long\" title=\"External link opens\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{E86C786D-011F-4280-894D-32554E81838A}|{AD1C8354-D3A0-4679-8E69-7A79EFFE3607}|{2B682F78-2DBB-4427-B98D-1FF13AE60514}\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}|{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}|{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}\",\n  \"ICES Locations\": \"{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}|{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}\",\n  \"ICES Scientists\": \"{F2F916BC-2EE9-4C65-BCAB-086ED6BB971A}|{372EE381-9B1A-49F5-AC1B-0D8675558A8D}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{545C70EB-0A3F-4646-A0F5-509EB7E15CF6}\",\n  \"Posted Date\": \"20000516T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2000\/January\/Postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-15T00:05:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\\\/\",\"name\":\"ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2000-05-16T04:00:00+00:00\",\"dateModified\":\"2023-06-15T00:05:55+00:00\",\"description\":\"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Articles\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"name\":\"ICES\",\"description\":\"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\"},\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\",\"name\":\"ICES\",\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"width\":\"676\",\"height\":\"618\",\"caption\":\"ICES\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/ICESOntario\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/ices-research-institute\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy","description":"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/","og_locale":"fr_FR","og_type":"article","og_title":"ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy","og_description":"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic","og_url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/","og_site_name":"ICES","article_publisher":"https:\/\/www.facebook.com\/ICESOntario\/","article_modified_time":"2023-06-15T00:05:55+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/","url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/","name":"ICES | Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy","isPartOf":{"@id":"https:\/\/www.ices.on.ca\/fr\/#website"},"datePublished":"2000-05-16T04:00:00+00:00","dateModified":"2023-06-15T00:05:55+00:00","description":"Background &#x2014; Several studies have indicated that estrogen may prime inflammatory and nociceptive pathways, leading to symptoms that mimic","breadcrumb":{"@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/postmenopausal-estrogen-replacement-therapy-and-increased-rates-of-cholecystectomy-and-appendectomy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ices.on.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Journal Articles","item":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/"},{"@type":"ListItem","position":3,"name":"Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy"}]},{"@type":"WebSite","@id":"https:\/\/www.ices.on.ca\/fr\/#website","url":"https:\/\/www.ices.on.ca\/fr\/","name":"ICES","description":"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE","publisher":{"@id":"https:\/\/www.ices.on.ca\/fr\/#organization"},"alternateName":"Institute for Clinical Evaluative Sciences","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ices.on.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ices.on.ca\/fr\/#organization","name":"ICES","alternateName":"Institute for Clinical Evaluative Sciences","url":"https:\/\/www.ices.on.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","contentUrl":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","width":"676","height":"618","caption":"ICES"},"image":{"@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ICESOntario\/","https:\/\/www.linkedin.com\/company\/ices-research-institute\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article\/3864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article"}],"about":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/types\/journal_article"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6746"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6742"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6734"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6733"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6735"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1304"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1385"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1119"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1325"}],"wp:attachment":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/media?parent=3864"}],"wp:term":[{"taxonomy":"migration-helper-automated","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-automated?post=3864"},{"taxonomy":"migration-manual","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-manual?post=3864"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/topic?post=3864"},{"taxonomy":"migration-helper-qa-sample-set","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-qa-sample-set?post=3864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}