{"id":3830,"date":"2001-04-01T00:00:00","date_gmt":"2001-04-01T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/major-trauma-in-elderly-adults-receiving-lipid-lowering-medications\/"},"modified":"2023-06-14T19:52:32","modified_gmt":"2023-06-14T23:52:32","slug":"major-trauma-in-elderly-adults-receiving-lipid-lowering-medications","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/major-trauma-in-elderly-adults-receiving-lipid-lowering-medications\/","title":{"rendered":"Major trauma in elderly adults receiving lipid-lowering medications"},"content":{"rendered":"

Background<\/strong> — Some clinical trials, laboratory experiments, and in vitro studies suggest that lipid-lowering medications predispose a person to traumatic injury.<\/p>\n

Methods<\/strong> — We used population-based administrative database analysis to study adults age 65 years or more over a 5-year interval (n = 1,348,259).<\/p>\n

Results<\/strong> — About 12% of the cohort received a prescription for a lipid-lowering medication and about 88% did not. The two groups had similar distributions of age, gender, and income. Overall, 2,557 (0.2%) were hospitalized for major trauma. Those who received a lipid-lowering medication were 39% less likely to sustain a major trauma than those who did not receive such medication (95% confidence interval, 29 to 47). Similar results were observed after adjustment for age, gender, and income; cardiac and neurologic medications; and lethality. No other cardiac or neurologic medication was associated with an apparent safety advantage.<\/p>\n

Conclusion<\/strong> — Lipid-lowering medications do not lead to a clinically important increase in the absolute risk of major trauma for elderly patients in the community.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background — Some clinical trials, laboratory experiments, and in vitro studies suggest that lipid-lowering medications predispose a person to traumatic injury. Methods — We used population-based administrative database analysis to study adults age 65 years or more over a 5-year interval (n = 1,348,259). Results — About 12% of the cohort received a prescription for […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[62,17,56],"migration-helper-qa-sample-set":[],"class_list":["post-3830","journal_article","type-journal_article","status-publish","hentry","topic-health-services-research","topic-older-people","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Redelmeier DA, Naylor CD, Brenneman FD, Sharkey PW, Juurlink DN. J Trauma<\/em>. 2001; 50(4):678-83.","source_url":"","ices_scientist":[1337,1304,1282],"site":[6733],"research_program":[6746],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"7B107AD9-868A-4B3A-8C47-9D771051BCB7","sitecore_item_name":"Major-trauma-in-elderly-adults-receiving-lipid-lowering-medications","sitecore_field_values":"{\n \"Title\": \"Major trauma in elderly adults receiving lipid-lowering medications\",\n \"Short title\": \"Major trauma in elderly adults\",\n \"Citation\": \"

Redelmeier DA, Naylor CD, Brenneman FD, Sharkey PW, Juurlink DN. J Trauma<\/em>. 2001; 50(4):678-83.<\/p>\",\n \"Abstract\": \"

Background<\/strong> — Some clinical trials, laboratory experiments, and in vitro studies suggest that lipid-lowering medications predispose a person to traumatic injury.<\/p>rn

Methods<\/strong> — We used population-based administrative database analysis to study adults age 65 years or more over a 5-year interval (n = 1,348,259).<\/p>rn

Results<\/strong> — About 12% of the cohort received a prescription for a lipid-lowering medication and about 88% did not. The two groups had similar distributions of age, gender, and income. Overall, 2,557 (0.2%) were hospitalized for major trauma. Those who received a lipid-lowering medication were 39% less likely to sustain a major trauma than those who did not receive such medication (95% confidence interval, 29 to 47). Similar results were observed after adjustment for age, gender, and income; cardiac and neurologic medications; and lethality. No other cardiac or neurologic medication was associated with an apparent safety advantage.<\/p>rn

Conclusion<\/strong> — Lipid-lowering medications do not lead to a clinically important increase in the absolute risk of major trauma for elderly patients in the community.<\/p>\",\n \"Keywords\": \"{D4620196-76F6-4AE4-9103-FB996B44FAC4}|{AD1C8354-D3A0-4679-8E69-7A79EFFE3607}|{A39C5396-16B7-4369-B0F9-31F6E91E46FC}\",\n \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}|{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}\",\n \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n \"ICES Scientists\": \"{31BBD6A4-EF6F-4859-AEFA-1FDFA8BF8BB5}|{545C70EB-0A3F-4646-A0F5-509EB7E15CF6}|{5268F1B0-EB3E-4577-93DF-3C70C9399847}\",\n \"Posted Date\": \"20010401T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2001\/January\/Major-trauma-in-elderly-adults-receiving-lipid-lowering-medications"},"yoast_head":"\nICES | Major trauma in elderly adults receiving lipid-lowering medications<\/title>\n<meta name=\"description\" content=\"Background — Some 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