{"id":3822,"date":"2001-03-01T00:00:00","date_gmt":"2001-03-01T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/proton-pump-inhibitors-compliance-with-a-mandated-step-up-program\/"},"modified":"2023-06-14T19:34:36","modified_gmt":"2023-06-14T23:34:36","slug":"proton-pump-inhibitors-compliance-with-a-mandated-step-up-program","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/proton-pump-inhibitors-compliance-with-a-mandated-step-up-program\/","title":{"rendered":"Proton pump inhibitors: compliance with a mandated step-up program"},"content":{"rendered":"<p><strong>Objective<\/strong> &#x2014; To assess compliance with a step-up approach to proton pump inhibitor (PPI) therapy before implementation of a new provincial policy to promote histamine-type 2 receptor antagonist (H2RA) use before PPI therapy.<\/p>\n<p><strong>Design<\/strong> &#x2014; Population-based, retrospective, open cohort study using prescribing and medical procedure data from January 1, 1995, to April 30, 1999.<\/p>\n<p><strong>Setting<\/strong> &#x2014; Health administration databases for the universal healthcare system in Ontario.<\/p>\n<p><strong>Participants<\/strong> &#x2014; Approximately 1.4 million residents of Ontario older than 65 years.<\/p>\n<p><strong>Main Outcome Measures<\/strong> &#x2014; Proportion of patients who received a trial of H2RA therapy or gastrointestinal diagnostic testing 12 months before starting PPI therapy in 1996.<\/p>\n<p><strong>Results<\/strong> &#x2014; Among the 25,870 patients who met study criteria in 1996, about 63% had received H2RAs 12 months before starting PPI therapy and 73% had had a trial of H2RAs or gastrointestinal diagnostic testing. Repeat analysis for January through April 1999, following the new policy implementation, showed that about 72% of patients had had a trial of H2RAs within 12 months of starting PPI therapy.<\/p>\n<p><strong>Conclusion<\/strong> &#x2014; A modest gain (9%) in compliance with using H2RA therapy within 12 months before starting PPI therapy was seen following introduction of the step-up intervention. In future, costs and benefits of potential interventions should be carefully considered before implementing new policies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective &#x2014; To assess compliance with a step-up approach to proton pump inhibitor (PPI) therapy before implementation of a new provincial policy to promote histamine-type 2 receptor antagonist (H2RA) use before PPI therapy. Design &#x2014; Population-based, retrospective, open cohort study using prescribing and medical procedure data from January 1, 1995, to April 30, 1999. Setting [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[61,56,60],"migration-helper-qa-sample-set":[],"class_list":["post-3822","journal_article","type-journal_article","status-publish","hentry","topic-health-economics","topic-pharmacoepidemiology-and-drug-safety","topic-policy-and-program-evaluation"],"acf":{"citation":"Mamdani MM, Tu K, Jaakkimainen L, Bica A, Hux J. <em>Can Fam Physician<\/em>. 2001; 47:531-5.","source_url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2018396\/","ices_scientist":[1325,1283,1268],"site":[6733,6735],"research_program":[6746],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"C93484FF-1503-4268-A78A-4AE067CCE8E7","sitecore_item_name":"Proton-pump-inhibitors-compliance-with-a-mandated-step-up-program","sitecore_field_values":"{\n  \"Title\": \"Proton pump inhibitors: compliance with a mandated step-up program\",\n  \"Short title\": \"Proton pump inhibitors: compliance with\",\n  \"Citation\": \"<p>Mamdani MM, Tu K, Jaakkimainen L, Bica A, Hux J. <em>Can Fam Physician<\/em>. 2001; 47:531-5.<\/p>\",\n  \"Abstract\": \"<p><strong>Objective<\/strong> &mdash; To assess compliance with a step-up approach to proton pump inhibitor (PPI) therapy before implementation of a new provincial policy to promote histamine-type 2 receptor antagonist (H2RA) use before PPI therapy.<\/p>n<p><strong>Design<\/strong> &mdash; Population-based, retrospective, open cohort study using prescribing and medical procedure data from January 1, 1995, to April 30, 1999.<\/p>n<p><strong>Setting<\/strong> &mdash; Health administration databases for the universal healthcare system in Ontario.<\/p>n<p><strong>Participants<\/strong> &mdash; Approximately 1.4 million residents of Ontario older than 65 years.<\/p>n<p><strong>Main Outcome Measures<\/strong> &mdash; Proportion of patients who received a trial of H2RA therapy or gastrointestinal diagnostic testing 12 months before starting PPI therapy in 1996.<\/p>n<p><strong>Results<\/strong> &mdash; Among the 25,870 patients who met study criteria in 1996, about 63% had received H2RAs 12 months before starting PPI therapy and 73% had had a trial of H2RAs or gastrointestinal diagnostic testing. Repeat analysis for January through April 1999, following the new policy implementation, showed that about 72% of patients had had a trial of H2RAs within 12 months of starting PPI therapy.<\/p>n<p><strong>Conclusion<\/strong> &mdash; A modest gain (9%) in compliance with using H2RA therapy within 12 months before starting PPI therapy was seen following introduction of the step-up intervention. In future, costs and benefits of potential interventions should be carefully considered before implementing new policies.<\/p>n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2018396\/\" title=\"External link opens\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{3B67F4BE-E30A-434A-8669-AE2A085C94E0}|{2C5686FC-D177-4ED9-9BF1-F6D3DB6B3F95}|{5B386094-8417-4B93-9D08-2F46BC0458AB}\",\n  \"Research Programs\": \"{5B1AF319-EC9B-4BF0-A9CD-D066ABE49D71}|{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}|{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n  \"ICES Scientists\": \"{F2F916BC-2EE9-4C65-BCAB-086ED6BB971A}|{D4F4F5B9-0B0A-48C9-A2E9-761818E1B404}|{4C08D086-0DAC-4164-B8DF-54317B959A2C}\",\n  \"Posted Date\": \"20010301T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2001\/January\/Proton-pump-inhibitors-compliance-with-a-mandated-step-up-program"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Proton pump inhibitors: compliance with a mandated step-up program<\/title>\n<meta name=\"description\" content=\"Objective &#x2014; 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