{"id":3610,"date":"2017-02-20T00:00:00","date_gmt":"2017-02-20T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/overdose-risk-in-young-children-of-women-prescribed-opioids\/"},"modified":"2023-06-14T19:49:38","modified_gmt":"2023-06-14T23:49:38","slug":"overdose-risk-in-young-children-of-women-prescribed-opioids","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/overdose-risk-in-young-children-of-women-prescribed-opioids\/","title":{"rendered":"Overdose risk in young children of women prescribed opioids"},"content":{"rendered":"<p><span class=\"bold\">Background and Objective<\/span> &#x2014; Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. <\/p>\n<p><strong>Methods<\/strong> &#x2014; We conducted a population-based, nested case control study in Ontario, Canada, between 2002 and 2015. We identified children aged &#x2264;10 years, whose mothers received publicly funded prescriptions for an opioid or a nonsteroidal antiinflammatory drug (comparator analgesic) in the preceding year. Cases were children who presented to hospital for or died of opioid overdose. Each case was matched with 4 controls with no opioid overdose. The primary outcome was the risk of opioid overdose. <\/p>\n<p><strong>Results<\/strong> &#x2014; We identified 103 children who presented to the hospital with opioid overdose and matched them with 412 controls. Half of the children with opioid overdose were &lt;2 years old. Compared with controls, children with an opioid overdose were far more likely to have a mother who received a prescription opioid (unadjusted odds ratio, 2.41; 95% confidence interval, 1.68&#x2013;3.45) and who was prescribed antidepressants. The most commonly implicated overdose opioids were codeine (53.4%), oxycodone (32.0%), and methadone (15.5%).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Young children of mothers prescribed opioids are at a markedly increased risk of overdose. Physicians, pharmacists, and parents should take measures to mitigate the risk of opioid-related harm to children, such as prescribing smaller quantities, emphasizing the importance of secure medication storage, and the prompt disposal of unused opioids.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background and Objective &#x2014; Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. Methods &#x2014; We conducted a population-based, nested case control study [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[27,56],"migration-helper-qa-sample-set":[],"class_list":["post-3610","journal_article","type-journal_article","status-publish","hentry","topic-pediatrics","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Finkelstein Y, Macdonald EM, Gonzalez A, Sivilotti ML, Mamdani MM, Juurlink DN; Canadian Drug Safety And Effectiveness Research Network (CDSERN). <em>Pediatrics<\/em>. 2017; 139(3):e20162887. Epub 2017 Feb 21.","source_url":"http:\/\/pediatrics.aappublications.org\/content\/139\/3\/e20162887.long","ices_scientist":[1282,1325,1229],"site":[6733],"research_program":[6746],"news_release":[7568],"journal_article":[],"atlas":[],"research_report":[],"infographic":[9406],"video":[],"downloads":null,"links":null,"sitecore_item_id":"8C5660B5-7E67-406C-9461-8F8D4F66157D","sitecore_item_name":"Overdose-risk-in-young-children-of-women-prescribed-opioids","sitecore_field_values":"{\n  \"__Valid from\": \"20170816T143429\",\n  \"Title\": \"Overdose risk in young children of women prescribed opioids\",\n  \"Short title\": \"Overdose risk in young children\",\n  \"Summary\": \"Children of women prescribed an opioid painkiller face a nearly 2.5-fold higher risk of being hospitalized for opioid overdose than children whose mothers don\u2019t receive these drugs.\",\n  \"Citation\": \"<p>Finkelstein Y, Macdonald EM, Gonzalez A, Sivilotti ML, Mamdani MM, Juurlink DN; Canadian Drug Safety And Effectiveness Research Network (CDSERN). <em>Pediatrics<\/em>. 2017; 139(3):e20162887. Epub 2017 Feb 21.<\/p>\",\n  \"Abstract\": \"<p><span class=\"bold\">Background and Objective<\/span> &mdash; Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. <\/p>n<p><strong>Methods<\/strong> &mdash; We conducted a population-based, nested case control study in Ontario, Canada, between 2002 and 2015. We identified children aged &le;10 years, whose mothers received publicly funded prescriptions for an opioid or a nonsteroidal antiinflammatory drug (comparator analgesic) in the preceding year. Cases were children who presented to hospital for or died of opioid overdose. Each case was matched with 4 controls with no opioid overdose. The primary outcome was the risk of opioid overdose. <\/p>n<p><strong>Results<\/strong> &mdash; We identified 103 children who presented to the hospital with opioid overdose and matched them with 412 controls. Half of the children with opioid overdose were &lt;2 years old. Compared with controls, children with an opioid overdose were far more likely to have a mother who received a prescription opioid (unadjusted odds ratio, 2.41; 95% confidence interval, 1.68&ndash;3.45) and who was prescribed antidepressants. The most commonly implicated overdose opioids were codeine (53.4%), oxycodone (32.0%), and methadone (15.5%).<\/p>n<p><strong>Conclusions<\/strong> &mdash; Young children of mothers prescribed opioids are at a markedly increased risk of overdose. Physicians, pharmacists, and parents should take measures to mitigate the risk of opioid-related harm to children, such as prescribing smaller quantities, emphasizing the importance of secure medication storage, and the prompt disposal of unused opioids.<\/p>n<p><a href=\"http:\/\/pediatrics.aappublications.org\/content\/139\/3\/e20162887.long\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{84FE2CDF-5B86-4CD1-A954-9886D022974F}|{3520E276-FC47-4BE8-BC0D-5FD075E6DBEF}\",\n  \"Related Products\": null,\n  \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{5268F1B0-EB3E-4577-93DF-3C70C9399847}|{F2F916BC-2EE9-4C65-BCAB-086ED6BB971A}|{2776AAE8-3E4C-4A6D-B9FD-E41C620EEB12}\",\n  \"Posted Date\": \"20170220T000000\",\n  \"Show on Publications Landing Page\": \"1\",\n  \"In The News\": \"{D63D0062-3442-46FC-98A1-9B2EA986C4C6}\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2017\/February\/Overdose-risk-in-young-children-of-women-prescribed-opioids"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Overdose risk in young children of women prescribed opioids<\/title>\n<meta name=\"description\" content=\"Background and Objective &#x2014; Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/overdose-risk-in-young-children-of-women-prescribed-opioids\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Overdose risk in young children of women prescribed opioids\" \/>\n<meta property=\"og:description\" content=\"Background and Objective &#x2014; Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/overdose-risk-in-young-children-of-women-prescribed-opioids\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T23:49:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/overdose-risk-in-young-children-of-women-prescribed-opioids\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/overdose-risk-in-young-children-of-women-prescribed-opioids\\\/\",\"name\":\"ICES | Overdose risk in young children of women prescribed opioids\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2017-02-20T05:00:00+00:00\",\"dateModified\":\"2023-06-14T23:49:38+00:00\",\"description\":\"Background and Objective &#x2014; 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